2IW8
STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | CELL DIVISION PROTEIN KINASE 2 | polymer | 302 | 34308.7 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE |
2 | B, D | CYCLIN-A2 | polymer | 260 | 29884.6 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | HOMO SAPIENS (HUMAN) | HUMAN CYCLIN A, CYCLIN-A |
3 | A, C | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | non-polymer | 402.5 | 2 | Chemie (4SP) | |||
4 | B, D | MONOTHIOGLYCEROL | non-polymer | 108.2 | 2 | Chemie (SGM) | |||
5 | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 174 - 432 (UniProt: P20248)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
His 82 | Phe 82 | engineered mutation |
Val 83 | Leu 83 | engineered mutation |
Asp 84 | His 84 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128386.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1021.3 | |
All* | Total formula weight | 129407.8 |