1B5F | | NATIVE CARDOSIN A FROM CYNARA CARDUNCULUS L. | | Descriptor: | PROTEIN (CARDOSIN A), alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Frazao, C., Bento, I., Carrondo, M.A. | | Deposit date: | 1999-01-06 | | Release date: | 1999-01-13 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Crystal structure of cardosin A, a glycosylated and Arg-Gly-Asp-containing aspartic proteinase from the flowers of Cynara cardunculus L.
J.Biol.Chem., 274, 1999
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1UMS | | STROMELYSIN-1 CATALYTIC DOMAIN WITH HYDROPHOBIC INHIBITOR BOUND, PH 7.0, 32OC, 20 MM CACL2, 15% ACETONITRILE; NMR ENSEMBLE OF 20 STRUCTURES | | Descriptor: | STROMELYSIN-1, ZINC ION, CALCIUM ION, ... | | Authors: | Van Doren, S.R., Kurochkin, A.V., Hu, W., Zuiderweg, E.R.P. | | Deposit date: | 1995-10-31 | | Release date: | 1996-03-08 | | Last modified: | 2020-09-23 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Protein Sci., 4, 1995
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1VQL | |
1VQM | |
2NCN | |
2RCJ | | SOLUTION STRUCTURE OF HUMAN IMMUNOGLOBULIN M | | Descriptor: | IgA1 light chain, IgA1 heavy chain, J chain | | Authors: | Perkins, S.J., Nealis, A.S., Sutton, B.J., Feinstein, A. | | Deposit date: | 2007-09-20 | | Release date: | 2008-01-22 | | Last modified: | 2020-09-23 | | Method: | SOLUTION SCATTERING | | Cite: | Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation.
J.Mol.Biol., 221, 1991
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3U4W | | SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC4B | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC4B, GLYCEROL, ... | | Authors: | Seeliger, M.A., Liu, D.R., Georghiou, G., Kleiner, R.E., Pulkoski-Gross, M. | | Deposit date: | 2011-10-10 | | Release date: | 2012-02-22 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat.Chem.Biol., 8, 2012
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3U51 | | SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC1 | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC1 | | Authors: | Seeliger, M.A., Liu, D.R., Georghiou, G., Kleiner, R.E., Pulkoski-Gross, M. | | Deposit date: | 2011-10-10 | | Release date: | 2012-02-22 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (2.241 Å) | | Cite: | Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat.Chem.Biol., 8, 2012
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3WFF | | MINERALOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN WITH COMPOUND 2B | | Descriptor: | Mineralocorticoid receptor, 6-[4-(2,4-difluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]-2H-1,4-benzoxazin-3(4H)-one, PHOSPHATE ION | | Authors: | Sogabe, S., Habuka, N. | | Deposit date: | 2013-07-19 | | Release date: | 2013-08-21 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.
Bioorg.Med.Chem., 21, 2013
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4GLQ | | CRYSTAL STRUCTURE OF THE BLUE-LIGHT ABSORBING FORM OF THE THERMOSYNECHOCOCCUS ELONGATUS PIXJ GAF-DOMAIN | | Descriptor: | Methyl-accepting chemotaxis protein, Phycoviolobilin, blue light-absorbing form | | Authors: | Burgie, E.S., Walker, J.M., Phillips Jr., G.N., Vierstra, R.D. | | Deposit date: | 2012-08-14 | | Release date: | 2013-01-16 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.772 Å) | | Cite: | A Photo-Labile Thioether Linkage to Phycoviolobilin Provides the Foundation for the Blue/Green Photocycles in DXCF-Cyanobacteriochromes.
Structure, 21, 2013
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4N2P | | STRUCTURE OF ARCHEASE FROM PYROCOCCUS HORIKOSHII | | Descriptor: | Protein archease, CALCIUM ION, ACETATE ION, ... | | Authors: | Desai, K.K., Bingman, C.A., Phillips Jr., G.N., Raines, R.T. | | Deposit date: | 2013-10-05 | | Release date: | 2014-01-01 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.435 Å) | | Cite: | A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.
Nucleic Acids Res., 42, 2014
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4O89 | | CRYSTAL STRUCTURE OF RTCA, THE RNA 3'-TERMINAL PHOSPHATE CYCLASE FROM PYROCOCCUS HORIKOSHII. | | Descriptor: | RNA 3'-terminal phosphate cyclase, CITRIC ACID | | Authors: | Desai, K.K., Bingman, C.A., Phillips Jr., G.N., Raines, R.T. | | Deposit date: | 2013-12-26 | | Release date: | 2014-09-10 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of RNA 3'-phosphate cyclase bound to substrate RNA.
Rna, 20, 2014
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4O8J | | CRYSTAL STRUCTURE OF RTCA, THE RNA 3'-TERMINAL PHOSPHATE CYCLASE FROM PYROCOCCUS HORIKOSHII, IN COMPLEX WITH RACAAA3'PHOSPHATE AND ADENINE. | | Descriptor: | RNA 3'-terminal phosphate cyclase, RNA, ADENOSINE, ... | | Authors: | Desai, K.K., Bingman, C.A., Phillips Jr., G.N., Raines, R.T. | | Deposit date: | 2013-12-27 | | Release date: | 2014-09-10 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structure of RNA 3'-phosphate cyclase bound to substrate RNA.
Rna, 20, 2014
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5F4Z | | THE CRYSTAL STRUCTURE OF AN EPOXIDE HYDROLASE FROM STREPTOMYCES CARZINOSTATICUS SUBSP. NEOCARZINOSTATICUS | | Descriptor: | Epoxide hydrolase, GLYCEROL, ACETATE ION, ... | | Authors: | Tan, K., Li, H., Jedrzejczak, R., BABNIGG, G., BINGMAN, C.A., YENNAMALLI, R., LOHMAN, J., Chang, C.Y., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2015-12-03 | | Release date: | 2016-02-17 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus
To Be Published
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5INJ | | CRYSTAL STRUCTURE OF PRENYLTRANSFERASE PRIB TERNARY COMPLEX WITH L-TRYPTOPHAN AND DIMETHYLALLYL THIOLODIPHOSPHATE (DMSPP) | | Descriptor: | Prenyltransferase, TRYPTOPHAN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Cao, H., Elshahawi, S., Benach, J., Wasserman, S.R., Morisco, L.L., Koss, J.W., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2016-03-07 | | Release date: | 2016-05-11 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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5K9M | | CRYSTAL STRUCTURE OF PRIB BINARY COMPLEX WITH PRODUCT DIPHOSPHATE | | Descriptor: | PriB Prenyltransferase, PYROPHOSPHATE 2-, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | | Authors: | Cao, H., Elshahawi, S., Benach, J., Wasserman, S.R., Morisco, L.L., Koss, J.W., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2016-06-01 | | Release date: | 2016-06-15 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
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5TJD | | COMPUTER-BASED RATIONAL DESIGN OF IMPROVED FUNCTIONALITY FOR ANTIBODY CATALYSTS TOWARD ORGANOPHOSPHORUS COMPOUNDS | | Descriptor: | FAB A.17 L47K mutant HEAVY CHAIN, FAB A.17 L47K mutant Light Chain | | Authors: | Chatziefthimiou, S., Stepanova, A., Smirnov, I., Gabibov, A., Wilmanns, M. | | Deposit date: | 2016-10-04 | | Release date: | 2018-05-02 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.
Proc.Natl.Acad.Sci.USA, 2020
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5UHJ | | THE CRYSTAL STRUCTURE OF A NATURAL PRODUCT BIOSYNTHETIC ENZYME FROM STREPTOMYCES SP. CB03234 | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, FORMIC ACID | | Authors: | Tan, K., Li, H., Endres, M., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | Deposit date: | 2017-01-11 | | Release date: | 2017-01-25 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The crystal structure of a natural product biosynthetic enzyme from Streptomyces sp. CB03234
To Be Published
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5UMP | | CRYSTAL STRUCTURE OF TNMS3, AN ANTIBIOTIC BINDING PROTEIN FROM STREPTOMYCES SP. CB03234 | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-01-29 | | Release date: | 2018-07-04 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
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5UMQ | | CRYSTAL STRUCTURE OF TNMS1, AN ANTIBIOTIC BINDING PROTEIN FROM STREPTOMYCES SP. CB03234 | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-01-29 | | Release date: | 2018-07-04 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
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5UMW | | CRYSTAL STRUCTURE OF TNMS2, AN ANTIBIOTIC BINDING PROTEIN FROM STREPTOMYCES SP. CB03234 | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, RIBOFLAVIN | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-01-29 | | Release date: | 2018-07-04 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
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5UMX | | CRYSTAL STRUCTURE OF TNMS3 IN COMPLEX WITH RIBOFLAVIN | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, RIBOFLAVIN | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-01-29 | | Release date: | 2018-07-04 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
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5UMY | | CRYSTAL STRUCTURE OF TNMS3 IN COMPLEX WITH TIANCIMYCIN | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, (1aS,11S,11aR,14Z,18R)-3,8,18-trihydroxy-11a-[(1R)-1-hydroxyethyl]-7-methoxy-11,11a-dihydro-4H-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinoline-4,9(10H)-dione | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., SHen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-01-29 | | Release date: | 2018-07-04 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Cell Chem Biol, 25, 2018
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5W27 | | CRYSTAL STRUCTURE OF TNMS3 IN COMPLEX WITH TIANCIMYCIN (TNM B) | | Descriptor: | Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate | | Authors: | Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips Jr., G.N., SHen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2017-06-05 | | Release date: | 2018-06-06 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of TnmS3 in complex with tiancimycin (TNM B)
To Be Published
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5WFN | | REVISED MODEL OF LEIOMODIN 2-MEDIATED ACTIN REGULATION (ALTERNATE REFINEMENT OF PDB 4RWT) | | Descriptor: | Actin-5C, Leiomodin-2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Yurtsever, Z., Eck, M.J., Dominguez, R. | | Deposit date: | 2017-07-12 | | Release date: | 2017-08-30 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of leiomodin 2 in complex with actin: a structural and functional reexamination
Biophys.J., 113, 2017
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