3N4M | |
3N97 | | RNA POLYMERASE ALPHA C-TERMINAL DOMAIN (E. COLI) AND SIGMA REGION 4 (T. AQ. MUTANT) BOUND TO (UP,-35 ELEMENT) DNA | | Descriptor: | RNA polymerase sigma factor, DNA-directed RNA polymerase subunit alpha, DNA (5'-D(*TP*GP*GP*AP*AP*AP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*CP*AP*TP*GP*G)-3'), ... | | Authors: | Lara-Gonzalez, S., Birktoft, J.J., Lawson, C.L. | | Deposit date: | 2010-05-28 | | Release date: | 2011-06-08 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (3.252 Å) | | Cite: | The RNA Polymerase alpha Subunit Recognizes the DNA Shape of the Upstream Promoter Element
Biochemistry, 2020
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5CIZ | |
5LYR | | STRUCTURE OF THE GH99 ENDO-ALPHA-MANNANASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH MANNOSE-ALPHA-1,3-NOEUROMYCIN | | Descriptor: | Glycosyl hydrolase family 71, ACETATE ION, alpha-D-mannopyranose, ... | | Authors: | Petricevic, M., Sobala, L.F., Fernandes, P.Z., Raich, L., Thompson, A.J., Bernardo-Seisdedos, G., Millet, O., Zhu, S., Sollogoub, M., Rovira, C., Jimenez-Barbero, J., Davies, G.J., Williams, S.J. | | Deposit date: | 2016-09-28 | | Release date: | 2017-01-11 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.14 Å) | | Cite: | Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-alpha-1,2-Mannanase.
J. Am. Chem. Soc., 139, 2017
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5N91 | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PPPP-OH | | Descriptor: | Protein enabled homolog, Ac-[2-Cl-F]-PPPP-OH, NITRATE ION | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-02-24 | | Release date: | 2017-06-28 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5N9C | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-1]-OH | | Descriptor: | Protein enabled homolog, Ac-[2-Cl-F]-PP-[ProM-1]-OH, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-02-24 | | Release date: | 2017-06-14 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.16 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5N9P | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-1]-NH2 | | Descriptor: | Protein enabled homolog, Ac-[2-Cl-F]-PP-[ProM-1]-NH2, CHLORIDE ION | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-02-26 | | Release date: | 2017-06-14 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NAJ | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-1]-[PROM-1]-OH | | Descriptor: | Protein enabled homolog, (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{S},7~{R},10~{R},13~{S})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-02-28 | | Release date: | 2017-05-24 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NBF | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-3]-OH | | Descriptor: | Protein enabled homolog, (3~{S},6~{S},7~{R},9~{a}~{R})-6-[[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonylamino]-7-methyl-5-oxidanylidene-1,2,3,6,7,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxylic acid, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-01 | | Release date: | 2017-05-24 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NBX | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-9]-OH | | Descriptor: | Protein enabled homolog, BROMIDE ION, 2-chloro-L-phenylalanine, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-02 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NC2 | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PPPPTEDEL-NH2 | | Descriptor: | Protein enabled homolog, Ac-[2-Cl-F]PPPPTEDEL-NH2, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-03 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NC7 | | ENAH EVH1 IN COMPLEX WITH AC-WPPPPTEDEL-NH2 | | Descriptor: | Protein enabled homolog, ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-03 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NCF | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-4]-OH | | Descriptor: | Protein enabled homolog, (1~{S},4~{S},7~{R},10~{R})-14-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-3,14-diazatricyclo[8.4.0.0^{3,7}]tetradec-8-ene-4-carboxylic acid, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-04 | | Release date: | 2017-06-14 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NCG | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-9]-OH | | Descriptor: | Protein enabled homolog, (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-04 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NCP | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-12]-OH | | Descriptor: | Protein enabled homolog, (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-06 | | Release date: | 2018-03-28 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5ND0 | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-1]-TEDEL-NH2 | | Descriptor: | Protein enabled homolog, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, SULFATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-07 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NDU | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-12]-OME | | Descriptor: | Protein enabled homolog, methyl (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylid ene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3, 7}]tridec-8-ene-13-carboxylate, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-09 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5NEG | | ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-13]-OET | | Descriptor: | Protein enabled homolog, ethyl (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-ethyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylate, NITRATE ION, ... | | Authors: | Barone, M., Roske, Y. | | Deposit date: | 2017-03-10 | | Release date: | 2018-03-21 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
Proc.Natl.Acad.Sci.USA, 2020
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5WTS | |
5ZKV | | SOLUTION STRUCTURE OF MOLTEN GLOBULE STATE OF L94G MUTANT OF HORSE CYTOCHROME-C | | Descriptor: | Cytochrome c, HEME C | | Authors: | Naiyer, A., Islam, A., Hassan, M.I., Sundd, M., Ahmad, F. | | Deposit date: | 2018-03-26 | | Release date: | 2019-05-22 | | Last modified: | 2020-11-25 | | Method: | SOLUTION NMR | | Cite: | Solution structure of molten globule state of L94G mutant of horse cytochrome-c
To Be Published
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6A6E | | CRYSTAL STRUCTURE OF THERMOSTABLE CYSTEINE DESULFURASE (FISUFS) FROM THERMOPHILIC FERVIDOBACTERIUM ISLANDICUM AW-1 | | Descriptor: | Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | | Authors: | Dhanasingh, I., Jin, H.S., Lee, D.W., Lee, S.H. | | Deposit date: | 2018-06-27 | | Release date: | 2019-10-09 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | The Sulfur Formation System Mediating Extracellular Cysteine-Cystine Recycling in Fervidobacterium islandicum AW-1 Is Associated with Keratin Degradation.
To Be Published
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6A6F | | CRYSTAL STRUCTURE OF PUTATIVE IRON-SULFUR CLUSTER ASSEMBLY SCAFFOLD PROTEIN FOR SUF SYSTEM (FISUFU) FROM THERMOPHILIC FERVIDOBACTERIUM ISLANDICUM AW-1 | | Descriptor: | Iron-sulfur cluster assembly scaffold protein NifU, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Dhanasingh, I., Jin, H.S., Lee, D.W., Lee, S.H. | | Deposit date: | 2018-06-27 | | Release date: | 2019-10-09 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Sulfur Formation System Mediating Extracellular Cysteine-Cystine Recycling in Fervidobacterium islandicum AW-1 Is Associated with Keratin Degradation.
To Be Published
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6A6G | | CRYSTAL STRUCTURE OF THERMOSTABLE FISUFS-SUFU COMPLEX FROM THERMOPHILIC FERVIDOBACTERIUM ISLANDICUM AW-1 | | Descriptor: | Cysteine desulfurase, Iron-sulfur cluster assembly scaffold protein NifU, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Dhanasingh, I., Jin, H.S., Lee, D.W., Lee, S.H. | | Deposit date: | 2018-06-27 | | Release date: | 2019-10-09 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | The Sulfur Formation System Mediating Extracellular Cysteine-Cystine Recycling in Fervidobacterium islandicum AW-1 Is Associated with Keratin Degradation.
To Be Published
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6D9F | | PROTEIN 60 WITH ALDEHYDE DEFORMYLATING OXIDASE ACTIVITY FROM KITASATOSPORA SETAE | | Descriptor: | Putative VlmB homolog, FE (III) ION, SULFATE ION, ... | | Authors: | Arenas, R., Wilson, D.K., Mak, W.S., Siegel, J.B. | | Deposit date: | 2018-04-28 | | Release date: | 2019-05-08 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily.
Biochemistry, 59, 2020
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6DDI | | CRYSTAL STRUCTURE OF THE HUMAN BRD2 BD1 BROMODOMAIN IN COMPLEX WITH A TETRAHYDROQUINOLINE ANALOGUE | | Descriptor: | Bromodomain-containing protein 2, 4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile, SULFATE ION, ... | | Authors: | White, S.W., Yun, M. | | Deposit date: | 2018-05-10 | | Release date: | 2019-11-13 | | Last modified: | 2020-11-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.
Cancer Res., 80, 2020
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