2N6J
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SOLUTION STRUCTURE OF ZMP1, A ZINC-DEPENDENT METALLOPROTEASE SECRETED BY CLOSTRIDIUM DIFFICILE
Descriptor:Zinc metalloprotease Zmp1, ZINC ION
Authors:Banci, L., Cantini, F., Scarselli, M., Rubino, J.T., Martinelli, M.
Deposit date:2015-08-24
Release date:2016-01-13
Last modified:2016-04-06
Method:SOLUTION NMR
Cite:Structural characterization of zinc-bound Zmp1, a zinc-dependent metalloprotease secreted by Clostridium difficile.
J.Biol.Inorg.Chem., 21, 2016
4PKQ
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND ZINC
Descriptor:Lethal factor, ZINC ION, TRIETHYLENE GLYCOL, ...
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKR
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR 10
Descriptor:Lethal factor, N~2~-benzyl-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION, ...
Authors:Maize, K.M., De la Mora, T., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKS
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR 11
Descriptor:Lethal factor, ZINC ION, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(pyridin-3-ylmethyl)-D-alaninamide, ...
Authors:Maize, K.M., De la Mora, T., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKT
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR 13
Descriptor:Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION
Authors:Maize, K.M., De la Mora, T., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKU
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR 15
Descriptor:Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M., De la Mora, T., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKV
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR 16
Descriptor:Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKW
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR GM6001
Descriptor:Lethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, ...
Authors:Maize, K.M., De la Mora, T., Finzel, B.C.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4WF6
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ANTHRAX TOXIN LETHAL FACTOR WITH BOUND SMALL MOLECULE INHIBITOR MK-31
Descriptor:Lethal factor, ZINC ION, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ...
Authors:Maize, K.M., De la Mora-Rey, T., Finzel, B.C.
Deposit date:2014-09-12
Release date:2015-09-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6521 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
4XM6
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ANTHRAX TOXIN LETHAL FACTOR WITH LIGAND-INDUCED BINDING POCKET
Descriptor:Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION, ...
Authors:Maize, K.M., De la Mora-Rey, T., Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM7
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ANTHRAX TOXIN LETHAL FACTOR WITH LIGAND-INDUCED BINDING POCKET
Descriptor:Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION, ...
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM8
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ANTHRAX TOXIN LETHAL FACTOR WITH LIGAND-INDUCED BINDING POCKET
Descriptor:Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2015-01-14
Release date:2015-11-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
5A0P
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APO-STRUCTURE OF METALLOPROTEASE ZMP1 FROM CLOSTRIDIUM DIFFICILE
Descriptor:ZINC METALLOPROTEASE ZMP1, ZINC ION
Authors:Schacherl, M., Pichlo, C., Neundorf, I., Baumann, U.
Deposit date:2015-04-22
Release date:2015-08-05
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium Difficile.
Structure, 23, 2015
5A0R
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PRODUCT PEPTIDE-BOUND STRUCTURE OF METALLOPROTEASE ZMP1 VARIANT E143A FROM CLOSTRIDIUM DIFFICILE
Descriptor:ZINC METALLOPROTEASE ZMP1, PRODUCT PEPTIDE, ZINC ION, ...
Authors:Schacherl, M., Pichlo, C., Neundorf, I., Baumann, U.
Deposit date:2015-04-22
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium Difficile.
Structure, 23, 2015
5A0S
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APO-STRUCTURE OF METALLOPROTEASE ZMP1 VARIANT E143A FROM CLOSTRIDIUM DIFFICILE
Descriptor:ZINC METALLOPROTEASE ZMP1, ZINC ION
Authors:Schacherl, M., Pichlo, C., Neundorf, I., Baumann, U.
Deposit date:2015-04-22
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium Difficile.
Structure, 23, 2015
5A0X
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SUBSTRATE PEPTIDE-BOUND STRUCTURE OF METALLOPROTEASE ZMP1 VARIANT E143AY178F FROM CLOSTRIDIUM DIFFICILE
Descriptor:ZINC METALLOPROTEASE ZMP1, SUBSTRATE PEPTIDE, ZINC ION
Authors:Schacherl, M., Pichlo, C., Neundorf, I., Baumann, U.
Deposit date:2015-04-23
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium Difficile.
Structure, 23, 2015
5D1S
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ANTHRAX TOXIN LETHAL FACTOR WITH HYDROXAMIC ACID INHIBITOR
Descriptor:Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5D1T
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ANTHRAX TOXIN LETHAL FACTOR WITH HYDROXAMIC ACID INHIBITOR
Descriptor:Lethal factor, ZINC ION, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5D1U
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ANTHRAX TOXIN LETHAL FACTOR WITH HYDROXAMIC ACID INHIBITOR
Descriptor:Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
Authors:Maize, K.M., Finzel, B.C.
Deposit date:2015-08-04
Release date:2015-11-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8503 Å)
Cite:Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5N12
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CRYSTAL STRUCTURE OF TCE TREATED RPPEP-1
Descriptor:Pro-Pro endopeptidase, ZINC ION, 2,2,2-tris-chloroethanol, ...
Authors:Pichlo, C., Schacherl, M., Baumann, U.
Deposit date:2017-02-04
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer.
Acta Crystallogr F Struct Biol Commun, 74, 2018
1J7N
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ANTHRAX TOXIN LETHAL FACTOR
Descriptor:Lethal Factor precursor, SULFATE ION, ZINC ION
Authors:Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Collier, R.J., Bienkowska, J., Lacy, D.B., Park, S., Leppla, S.H., Hanna, P., Liddington, R.C.
Deposit date:2001-05-17
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1JKY
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR (LF): WILD-TYPE LF COMPLEXED WITH THE N-TERMINAL SEQUENCE OF MAPKK2
Descriptor:Lethal Factor, mitogen-activated protein kinase kinase 2
Authors:Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Collier, R.J., Bienkowska, J., Lacy, D.B., Park, S., Leppla, S.H., Hanna, P., Liddington, R.C.
Deposit date:2001-07-13
Release date:2001-11-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1PWP
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CRYSTAL STRUCTURE OF THE ANTHRAX LETHAL FACTOR COMPLEXED WITH SMALL MOLECULE INHIBITOR NSC 12155
Descriptor:Lethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWQ
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH THIOACETYL-TYR-PRO-MET-AMIDE, A METAL-CHELATING PEPTIDYL SMALL MOLECULE INHIBITOR
Descriptor:Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
1PWU
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CRYSTAL STRUCTURE OF ANTHRAX LETHAL FACTOR COMPLEXED WITH (3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE), A KNOWN SMALL MOLECULE INHIBITOR OF MATRIX METALLOPROTEASES.
Descriptor:Lethal factor, ZINC ION, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
Authors:Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.
Deposit date:2003-07-02
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nat.Struct.Mol.Biol., 11, 2004
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