1YY6
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH AN EBNA1 PEPTIDE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Epstein-Barr nuclear antigen-1, SODIUM ION
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M., Shire, K., Nguyen, T., Zhang, R., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.
Deposit date:2005-02-23
Release date:2005-04-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
1YZE
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF USP7/HAUSP.
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M.N., Shire, K., Nguyen, T., Zhang, R.G., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.
Deposit date:2005-02-28
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
2CR2
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SOLUTION STRUCTURE OF N-TERMINAL DOMAIN OF SPECKLE-TYPE POZ PROTEIN
Descriptor:Speckle-type POZ protein
Authors:Nagashima, T., Hayashi, F., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-20
Release date:2005-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of N-terminal domain of speckle-type POZ protein
To be Published
2F1W
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, CALCIUM ION
Authors:Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1X
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7 BOUND TO A P53 PEPTIDE
Descriptor:HAUSP/USP7
Authors:Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1Y
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7 BOUND TO A MDM2 PEPTIDE
Descriptor:HAUSP/USP7
Authors:Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2FOJ
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH P53 PEPTIDE 364-367
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOO
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH P53 PEPTIDE 359-362
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOP
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH MDM2 PEPTIDE 147-150
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, mdm2 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2XXN
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STRUCTURE OF THE VIRF4-HAUSP TRAF DOMAIN COMPLEX
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7, K10
Authors:Choi, W.C., Hwang, J., Kim, M.H.
Deposit date:2010-11-11
Release date:2011-11-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Bilateral Inhibition of Hausp Deubiquitinase by a Viral Interferon Regulatory Factor Protein
Nat.Struct.Mol.Biol., 18, 2011
3HQH
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, MacroH2A, ZINC ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-06
Release date:2009-10-20
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQL
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES:SPOPMATHX-PUCSBC1_PEP2
Descriptor:Speckle-type POZ protein, Puckered, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HQM
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-CISBC2
Descriptor:Speckle-type POZ protein, Protein cubitus interruptus, SULFATE ION
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3HSV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX-MACROH2ASBCPEP2
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Zhuang, M., Schulman, B.A., Miller, D.
Deposit date:2009-06-10
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
3IVB
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-MACROH2ASBCPEP1
Descriptor:Speckle-type POZ protein, Core histone macro-H2A.1, ZINC ION, ...
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-08-31
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure 9
To be Published
3IVQ
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-CISBC2
Descriptor:Speckle-type POZ protein, CiSBC2
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVV
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATH-PUCSBC1_PEP1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Schulman, B.A., Miller, D.J., Calabrese, M.F., Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3MQR
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CRYSTAL STRUCTURE OF THE USP7:HDMX(AHSS) COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, HdmX Peptide
Authors:Saridakis, V.
Deposit date:2010-04-28
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure Of USP7
To be Published
3MQS
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CRYSTAL STRUCTURE OF THE USP7:HDM2(PSTS) COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Hdm2 peptide
Authors:Saridakis, V.
Deposit date:2010-04-28
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of USP7
To be Published
4JJQ
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CRYSTAL STRUCTURE OF USP7-NTD WITH AN E2 ENZYME
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin-conjugating enzyme E2 E1
Authors:Saridakis, V.
Deposit date:2013-03-08
Release date:2013-05-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
J. Biol. Chem., 288, 2013
4KG9
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CRYSTAL STRUCTURE OF USP7-NTD WITH MCM-BP
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Mini-chromosome maintenance complex-binding protein
Authors:Saridakis, V., Luthra, N.
Deposit date:2013-04-29
Release date:2013-11-13
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A role for USP7 in DNA replication.
Mol.Cell.Biol., 34, 2014
4O1V
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SPOP PROMOTES TUMORIGENESIS BY ACTING AS A KEY REGULATORY HUB IN KIDNEY CANCER
Descriptor:Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Authors:Calabrese, M.F., Watson, E.R., Schulman, B.A.
Deposit date:2013-12-16
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
Cancer Cell, 25, 2014
4YSI
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STRUCTURE OF USP7 WITH A NOVEL VIRAL PROTEIN
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, SER-PRO-GLY-GLU-GLY-PRO-SER-GLY, GLYCEROL
Authors:Chavoshi, S., Saridakis, V.
Deposit date:2015-03-17
Release date:2016-02-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure of USP7 with a novel viral protein
J.Biol.Chem., 2016
2F1Z
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CRYSTAL STRUCTURE OF HAUSP
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
3HQI
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STRUCTURES OF SPOP-SUBSTRATE COMPLEXES: INSIGHTS INTO MOLECULAR ARCHITECTURES OF BTB-CUL3 UBIQUITIN LIGASES: SPOPMATHX/BTB/3-BOX-PUCSBC1
Descriptor:Speckle-type POZ protein, PucSBC1
Authors:Zhuang, M., Schulman, B.A.
Deposit date:2009-06-07
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Mol.Cell, 36, 2009
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