2IOP
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CRYSTAL STRUCTURE OF FULL-LENGTH HTPG, THE ESCHERICHIA COLI HSP90, BOUND TO ADP
Descriptor:Chaperone protein htpG, ADENOSINE-5'-DIPHOSPHATE
Authors:Shiau, A.K., Harris, S.F., Agard, D.A.
Deposit date:2006-10-10
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
2IOQ
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CRYSTAL STRUCTURE OF FULL-LENGTH HTPG, THE ESCHERICHIA COLI HSP90
Descriptor:Chaperone protein htpG
Authors:Shiau, A.K., Harris, S.F., Agard, D.A.
Deposit date:2006-10-10
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
4IPE
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CRYSTAL STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH AMPPNP
Descriptor:TNF receptor-associated protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Partridge, J.R., Lavery, L.A., Agard, D.A.
Deposit date:2013-01-09
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.289 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
4IVG
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CRYSTAL STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) NTD-MIDDLE DOMAIN DIMER WITH AMPPNP
Descriptor:TNF receptor-associated protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PHOSPHATE ION, ...
Authors:Partridge, J.R., Lavery, L.A., Agard, D.A.
Deposit date:2013-01-22
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
4IYN
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STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH ADP-ALF4-
Descriptor:TNF receptor-associated protein 1, COBALT (II) ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Partridge, J.R., Lavery, L.A., Agard, D.A.
Deposit date:2013-01-28
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
4J0B
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STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH ADP-BEF3
Descriptor:TNF receptor-associated protein 1, COBALT (II) ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Partridge, J.R., Lavery, L.A., Agard, D.A.
Deposit date:2013-01-30
Release date:2014-01-22
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
5FWK
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ATOMIC CRYOEM STRUCTURE OF HSP90-CDC37-CDK4 COMPLEX
Descriptor:HEAT SHOCK PROTEIN HSP 90 BETA, HSP90 CO-CHAPERONE CDC37, CYCLIN-DEPENDENT KINASE 4, ...
Authors:Verba, K.A., Wang, R.Y.R., Arakawa, A., Liu, Y., Yokoyama, S., Agard, D.A.
Deposit date:2016-02-17
Release date:2016-07-06
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
5FWL
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ATOMIC CRYOEM STRUCTURE OF HSP90-CDC37-CDK4 COMPLEX
Descriptor:HEAT SHOCK PROTEIN HSP 90 BETA, HSP90 CO-CHAPERONE CDC37, CYCLIN-DEPENDENT KINASE 4, ...
Authors:Verba, K.A., Wang, R.Y.R., Arakawa, A., Liu, Y., Yokoyama, S., Agard, D.A.
Deposit date:2016-02-18
Release date:2016-07-06
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
5FWM
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ATOMIC CRYOEM STRUCTURE OF HSP90-CDC37-CDK4 COMPLEX
Descriptor:HEAT SHOCK PROTEIN HSP 90 BETA, HSP90 CO-CHAPERONE CDC37, CYCLIN-DEPENDENT KINASE 4, ...
Authors:Verba, K.A., Wang, R.Y.R., Arakawa, A., Liu, Y., Yokoyama, S., Agard, D.A.
Deposit date:2016-02-18
Release date:2016-07-06
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Atomic Structure of Hsp90-Cdc37-Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
5FWP
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ATOMIC CRYOEM STRUCTURE OF HSP90-CDC37-CDK4 COMPLEX
Descriptor:HEAT SHOCK PROTEIN HSP 90 BETA, HSP90 CO-CHAPERONE CDC37, CYCLIN-DEPENDENT KINASE 4, ...
Authors:Verba, K.A., Wang, R.Y.R., Arakawa, A., Liu, Y., Yokoyama, S., Agard, D.A.
Deposit date:2016-02-18
Release date:2016-10-26
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Atomic Structure of Hsp90:Cdc37:Cdk4 Reveals that Hsp90 Traps and Stabilizes an Unfolded Kinase.
Science, 352, 2016
5TTH
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HETERODIMERIC SPYCATCHER/SPYTAG-FUSED ZEBRAFISH TRAP1 IN ATP/ADP-HYBRID STATE
Descriptor:C-terminal SpyCatcher fusion of wildtype zebrafish TNF receptor-associated protein 1, C-terminal Spytag fusion of R417A zebrafish TNF receptor-associated protein 1, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Elnatan, D., Betegon, M., Liu, Y., Agard, D.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
5TVX
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CRYSTAL STRUCTURE OF MITOCHONDRIAL HSP90 (TRAP1) WITH ATP IN ABSENCE OF MG, FULLY HYDROLYZED
Descriptor:TNF receptor-associated protein 1, ADENOSINE-5'-DIPHOSPHATE
Authors:Elnatan, D., Betegon, M., Agard, D.A.
Deposit date:2016-11-10
Release date:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Sequential ATP hydrolysis drives flipping of Mitochondrial Hsp90 TRAP1 asymmetry
To Be Published
6D14
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ZEBRAFISH TRAP1 BOUND TO AMPPNP AND CALCIUM IN THE ASYMMETRIC CLOSED STATE
Descriptor:TNF receptor-associated protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CALCIUM ION
Authors:Elnatan, D., Agard, D.A.
Deposit date:2018-04-11
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium
To Be Published
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