5QDE
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000740A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, ~{N}-(4-fluorophenyl)-4-methyl-piperazine-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.764 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDF
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000295A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, ~{N}2-(1~{H}-benzimidazol-2-yl)benzene-1,2-diamine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.712 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDG
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000294A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 8-[(dimethylamino)methyl]-4-methyl-7-oxidanyl-chromen-2-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDH
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000004A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 1-(3-chlorophenyl)-N-methylmethanamine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.682 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDI
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000157A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N-(2-phenylethyl)methanesulfonamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.623 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDJ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000211A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N-(4-methyl-1,3-thiazol-2-yl)propanamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDK
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000069A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, [4-(1H-benzimidazol-1-yl)phenyl]methanol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDL
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000072A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, methyl 2-(4-aminophenoxy)benzoate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDM
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000074A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.647 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDN
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000163A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N-{4-[(2S)-butan-2-yl]phenyl}methanesulfonamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.821 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDO
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOCR000171B
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 2-(thiophen-2-yl)-1H-imidazole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDP
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000207A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.744 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDQ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_XST00000847B
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N,N-dimethylpyridin-4-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.575 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDR
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000089A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, methyl 3-(methylsulfonylamino)benzoate, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.784 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDS
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000108A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, N-[(4-cyanophenyl)methyl]morpholine-4-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDT
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000475A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, ~{N}-(1-propyl-1,2,3,4-tetrazol-5-yl)furan-2-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.821 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDU
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000466A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, ~{N},~{N},5,6-tetramethylthieno[2,3-d]pyrimidin-4-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.672 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDV
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000574A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 1-[(4-fluorophenyl)methyl]benzimidazole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.773 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDW
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000465A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 2-methoxy-N-[(1R)-1-phenylethyl]acetamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.212 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDX
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000484A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, {N}-[(2~{S})-1-diazanyl-3-(4-hydroxyphenyl)-1-oxidanylidene-propan-2-yl]ethanamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.062 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDY
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_XST00000599C
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.835 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QDZ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000435A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, (azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QE0
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000648A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 3-[(1,2-oxazole-5-carbonyl)amino]benzoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QE1
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000645A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, (2,3-dihydro-1,2,3-benzothiadiazol-5-yl)(morpholin-4-yl)methanone, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.685 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
5QE2
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF PTP1B IN COMPLEX WITH COMPOUND_FMOPL000398A
Descriptor:Tyrosine-protein phosphatase non-receptor type 1, 1-methyl-N-{[(2S)-oxolan-2-yl]methyl}-1H-pyrazole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
Deposit date:2018-08-30
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.787 Å)
Cite:Allosteric inhibition of a dynamic enzyme from multitemperature crystallography, fragment screening, and covalent tethering
To be published
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