5QAY
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OXA-48 IN COMPLEX WITH COMPOUND 32
Descriptor:Beta-lactamase, 3-(1-methylpyrrol-2-yl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAV
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OXA-48 IN COMPLEX WITH COMPOUND 26B
Descriptor:Beta-lactamase, 1,2-ETHANEDIOL, 3-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]benzoic acid, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAD
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OXA-48 IN COMPLEX WITH COMPOUND 8A
Descriptor:Beta-lactamase, 3-(2-fluorophenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAU
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OXA-48 IN COMPLEX WITH COMPOUND 26A
Descriptor:Beta-lactamase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB2
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OXA-48 IN COMPLEX WITH COMPOUND 38
Descriptor:Beta-lactamase, 3-quinolin-6-yl-5-quinolin-7-yl-benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAP
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OXA-48 IN COMPLEX WITH COMPOUND 21A
Descriptor:Beta-lactamase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB1
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OXA-48 IN COMPLEX WITH COMPOUND 36
Descriptor:Beta-lactamase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA7
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OXA-48 IN COMPLEX WITH COMPOUND 4B
Descriptor:Beta-lactamase, 3-(3-hydroxyphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAM
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OXA-48 IN COMPLEX WITH COMPOUND 17
Descriptor:Beta-lactamase, 3-[4-(methylsulfonylamino)phenyl]benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA9
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OXA-48 IN COMPLEX WITH COMPOUND 5
Descriptor:Beta-lactamase, 3-[3-(hydroxymethyl)phenyl]benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAI
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OXA-48 IN COMPLEX WITH COMPOUND 12A
Descriptor:Beta-lactamase, 3-(3-methylsulfonylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAK
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OXA-48 IN COMPLEX WITH COMPOUND 14
Descriptor:Beta-lactamase, 3-[3-(dimethylamino)phenyl]benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAS
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OXA-48 IN COMPLEX WITH COMPOUND 23B
Descriptor:Beta-lactamase, 3-[4-(2-acetamidoethyl)phenyl]benzoic acid, 1,2-ETHANEDIOL
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAT
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OXA-48 IN COMPLEX WITH COMPOUND 24
Descriptor:Beta-lactamase, 3-[3-(acetyloxymethyl)phenyl]benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA4
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OXA-48 IN COMPLEX WITH COMPOUND 3A
Descriptor:Beta-lactamase, 3-(2-methylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA5
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OXA-48 IN COMPLEX WITH COMPOUND 3B
Descriptor:Beta-lactamase, 3-(3-methylphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA6
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OXA-48 IN COMPLEX WITH COMPOUND 4A
Descriptor:Beta-lactamase, 3-(2-hydroxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAA
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OXA-48 IN COMPLEX WITH COMPOUND 6A
Descriptor:Beta-lactamase, 3-(2-methoxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAH
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OXA-48 IN COMPLEX WITH COMPOUND 9B
Descriptor:Beta-lactamase, 3-(3-methoxycarbonylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAL
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OXA-48 IN COMPLEX WITH COMPOUND 11B
Descriptor:Beta-lactamase, 3-(4-aminocarbonylphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB0
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OXA-48 IN COMPLEX WITH COMPOUND 35
Descriptor:Beta-lactamase, 3-pyridin-2-ylbenzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QB4
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OXA-48 IN COMPLEX WITH SUBSTRATE IMIPENEM
Descriptor:Beta-lactamase, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAC
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OXA-48 IN COMPLEX WITH COMPOUND 6C
Descriptor:Beta-lactamase, 3-(4-methoxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAJ
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OXA-48 IN COMPLEX WITH COMPOUND 13
Descriptor:Beta-lactamase, 3-(4-aminophenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAO
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OXA-48 IN COMPLEX WITH COMPOUND 19B
Descriptor:Beta-lactamase, 3-[4-(methylsulfonylaminomethyl)phenyl]benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
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