Mine: Updated entries

6E3K
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INTERFERON GAMMA SIGNALLING COMPLEX WITH IFNGR1 AND IFNGR2
Descriptor:Interferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ...
Authors:Jude, K.M., Mendoza, J.L., Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6E3L
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INTERFERON GAMMA SIGNALLING COMPLEX WITH IFNGR1 AND IFNGR2
Descriptor:Interferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ...
Authors:Jude, K.M., Mendoza, J.L., Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6I0Z
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1
Descriptor:Fascin, ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I10
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 2
Descriptor:Fascin, 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one, ACETATE ION, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I11
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3
Descriptor:Fascin, ACETATE ION, ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I12
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 5
Descriptor:Fascin, ACETATE ION, 2-[(4-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I13
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I14
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9
Descriptor:Fascin, ACETATE ION, 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I15
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11
Descriptor:Fascin, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I16
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 15
Descriptor:Fascin, ACETATE ION, 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I17
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I18
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CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176
Descriptor:Fascin, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Schuettelkopf, A.W.
Deposit date:2018-10-27
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg.Med.Chem.Lett., 29, 2019
6I6B
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CRYSTAL STRUCTURE OF THE KDEL RECEPTOR IN THE PEPTIDE FREE STATE.
Descriptor:ER lumen protein-retaining receptor 2, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Braeuer, P., Newstead, S.
Deposit date:2018-11-15
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.
Science, 363, 2019
6I6H
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CRYSTAL STRUCTURE OF THE KDEL RECEPTOR IN THE PEPTIDE BOUND STATE
Descriptor:ER lumen protein-retaining receptor 2, AEKDEL peptide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Braeuer, P., Newstead, S.
Deposit date:2018-11-15
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.
Science, 363, 2019
6I6J
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CRYSTAL STRUCTURE OF THE KDEL RECEPTOR BOUND TO SYNTHETIC NANOBODY.
Descriptor:ER lumen protein-retaining receptor 2, Sybody, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Braeuer, P., Newstead, S.
Deposit date:2018-11-15
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.
Science, 363, 2019
6NHW
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE DEATH RECEPTOR 5 - DIMER OF TRIMER
Descriptor:Tumor necrosis factor receptor superfamily member 10B
Authors:Chou, J.J., Pan, L., Fu, Q., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H.
Deposit date:2018-12-24
Release date:2019-02-27
Last modified:2019-03-20
Method:SOLUTION NMR
Cite:Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
6NHY
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE DEATH RECEPTOR 5 MUTANT (G217Y) - TRIMER ONLY
Descriptor:Tumor necrosis factor receptor superfamily member 10B
Authors:Chou, J.J., Pan, L., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H., Liu, Z.
Deposit date:2018-12-24
Release date:2019-02-27
Last modified:2019-03-20
Method:SOLUTION NMR
Cite:Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
6Q4T
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KOD DNA POL IN A CLOSED TERNARY COMPLEX WITH 7-DEAZA-7-(2-(2-HYDROXYETHOXY)-N-(PROP-2-YN-1-YL)ACETAMIDE)-2-DATP
Descriptor:DNA polymerase,DNA polymerase,DNA polymerase, DNA (5'-D(P*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6Q4U
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KLENTAQ DNA POL IN A CLOSED TERNARY COMPLEX WITH 7-DEAZA-7-(2-(2-HYDROXYETHOXY)-N-(PROP-2-YN-1-YL)ACETAMIDE)-2-DATP
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6Q4V
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KLENTAQ DNA POLYMERASE IN COMPLEX WITH DATP
Descriptor:DNA polymerase I, thermostable, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ...
Authors:Kropp, H.M., Diederichs, K., Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 2019
6QA2
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R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Nucleoside diphosphate kinase, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Dautant, A., Henri, J., Wales, T.E., Meyer, P., Engen, J.R., Georgescauld, F.
Deposit date:2018-12-18
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.
Biochemistry, 58, 2019
6QAS
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CRYSTAL STRUCTURE OF ULK1 IN COMPLEXED WITH PF-03814735
Descriptor:Serine/threonine-protein kinase ULK1, SULFATE ION, CITRIC ACID, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAT
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH HESPERADIN
Descriptor:Serine/threonine-protein kinase ULK2, N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAU
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT67307
Descriptor:Serine/threonine-protein kinase ULK2, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAV
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT68921
Descriptor:Serine/threonine-protein kinase ULK2, ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019