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9E3A

Cryo-EM structure of PRMT5/WDR77 in complex with 6S complex (pICln PBM local refinement)

Functional Information from GO Data
ChainGOidnamespacecontents
J0000387biological_processspliceosomal snRNP assembly
J0000785cellular_componentchromatin
J0002039molecular_functionp53 binding
J0003714molecular_functiontranscription corepressor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005694cellular_componentchromosome
J0005737cellular_componentcytoplasm
J0005794cellular_componentGolgi apparatus
J0005829cellular_componentcytosol
J0006325biological_processchromatin organization
J0006338biological_processchromatin remodeling
J0006353biological_processDNA-templated transcription termination
J0006355biological_processregulation of DNA-templated transcription
J0007088biological_processregulation of mitotic nuclear division
J0008168molecular_functionmethyltransferase activity
J0008327molecular_functionmethyl-CpG binding
J0008469molecular_functionhistone arginine N-methyltransferase activity
J0010468biological_processregulation of gene expression
J0016274molecular_functionprotein-arginine N-methyltransferase activity
J0016740molecular_functiontransferase activity
J0018216biological_processpeptidyl-arginine methylation
J0032259biological_processmethylation
J0032922biological_processcircadian regulation of gene expression
J0032991cellular_componentprotein-containing complex
J0034709cellular_componentmethylosome
J0035097cellular_componenthistone methyltransferase complex
J0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
J0035246biological_processpeptidyl-arginine N-methylation
J0042054molecular_functionhistone methyltransferase activity
J0042118biological_processendothelial cell activation
J0042802molecular_functionidentical protein binding
J0043021molecular_functionribonucleoprotein complex binding
J0044020molecular_functionhistone H4R3 methyltransferase activity
J0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
J0044877molecular_functionprotein-containing complex binding
J0045596biological_processnegative regulation of cell differentiation
J0045892biological_processnegative regulation of DNA-templated transcription
J0046982molecular_functionprotein heterodimerization activity
J0048026biological_processpositive regulation of mRNA splicing, via spliceosome
J0048511biological_processrhythmic process
J0048714biological_processpositive regulation of oligodendrocyte differentiation
J0070372biological_processregulation of ERK1 and ERK2 cascade
J0070888molecular_functionE-box binding
J0090161biological_processGolgi ribbon formation
J0097421biological_processliver regeneration
J0140938molecular_functionhistone H3 methyltransferase activity
J1901796biological_processregulation of signal transduction by p53 class mediator
J1904992biological_processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
K0000209biological_processprotein polyubiquitination
K0000387biological_processspliceosomal snRNP assembly
K0003713molecular_functiontranscription coactivator activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005794cellular_componentGolgi apparatus
K0005829cellular_componentcytosol
K0006357biological_processregulation of transcription by RNA polymerase II
K0006511biological_processubiquitin-dependent protein catabolic process
K0007309biological_processoocyte axis specification
K0008284biological_processpositive regulation of cell population proliferation
K0008285biological_processnegative regulation of cell population proliferation
K0008327molecular_functionmethyl-CpG binding
K0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
K0034709cellular_componentmethylosome
K0045893biological_processpositive regulation of DNA-templated transcription
K0048026biological_processpositive regulation of mRNA splicing, via spliceosome
K0060528biological_processsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
K0060767biological_processepithelial cell proliferation involved in prostate gland development
K0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
K1990234cellular_componenttransferase complex
K1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
L0000387biological_processspliceosomal snRNP assembly
L0003723molecular_functionRNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005681cellular_componentspliceosomal complex
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005886cellular_componentplasma membrane
L0005929cellular_componentcilium
L0006397biological_processmRNA processing
L0008380biological_processRNA splicing
L0034709cellular_componentmethylosome
L0034715cellular_componentpICln-Sm protein complex
L0045292biological_processmRNA cis splicing, via spliceosome
L0048026biological_processpositive regulation of mRNA splicing, via spliceosome
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL
ChainResidueDetails
KALA140-LEU154

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000269|Ref.10, ECO:0007744|PubMed:22814378
ChainResidueDetails
LSER2
JGLU444

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
LSER102
JPHE327
JLYS333
JGLU392
JASP419
JGLU435
JGLU444

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
LSER144

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
LSER193
LSER195
LSER198
LSER210

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
LTHR223

237992

PDB entries from 2025-06-25

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