9E3A

Cryo-EM structure of PRMT5/WDR77 in complex with 6S complex (pICln PBM local refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000785	cellular_component	chromatin
J	0002039	molecular_function	p53 binding
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006351	biological_process	DNA-templated transcription
J	0006353	biological_process	DNA-templated transcription termination
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006479	biological_process	protein methylation
J	0007088	biological_process	regulation of mitotic nuclear division
J	0008168	molecular_function	methyltransferase activity
J	0008327	molecular_function	methyl-CpG binding
J	0010468	biological_process	regulation of gene expression
J	0016274	molecular_function	protein-arginine N-methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0018216	biological_process	peptidyl-arginine methylation
J	0032259	biological_process	methylation
J	0032922	biological_process	circadian regulation of gene expression
J	0032991	cellular_component	protein-containing complex
J	0034709	cellular_component	methylosome
J	0035097	cellular_component	histone methyltransferase complex
J	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
J	0035246	biological_process	peptidyl-arginine N-methylation
J	0042054	molecular_function	histone methyltransferase activity
J	0042118	biological_process	endothelial cell activation
J	0042802	molecular_function	identical protein binding
J	0043021	molecular_function	ribonucleoprotein complex binding
J	0044020	molecular_function	histone H4R3 methyltransferase activity
J	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
J	0044877	molecular_function	protein-containing complex binding
J	0045596	biological_process	negative regulation of cell differentiation
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0046982	molecular_function	protein heterodimerization activity
J	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
J	0048511	biological_process	rhythmic process
J	0048714	biological_process	positive regulation of oligodendrocyte differentiation
J	0070372	biological_process	regulation of ERK1 and ERK2 cascade
J	0070888	molecular_function	E-box binding
J	0090161	biological_process	Golgi ribbon formation
J	0097421	biological_process	liver regeneration
J	0140938	molecular_function	histone H3 methyltransferase activity
J	1901796	biological_process	regulation of signal transduction by p53 class mediator
J	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
J	2000234	biological_process	positive regulation of rRNA processing
K	0000209	biological_process	protein polyubiquitination
K	0000387	biological_process	spliceosomal snRNP assembly
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008327	molecular_function	methyl-CpG binding
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0034709	cellular_component	methylosome
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
K	1990234	cellular_component	transferase complex
K	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	2000234	biological_process	positive regulation of rRNA processing
L	0000387	biological_process	spliceosomal snRNP assembly
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0006397	biological_process	mRNA processing
L	0006821	biological_process	chloride transport
L	0006884	biological_process	cell volume homeostasis
L	0008380	biological_process	RNA splicing
L	0015630	cellular_component	microtubule cytoskeleton
L	0034709	cellular_component	methylosome
L	0034715	cellular_component	pICln-Sm protein complex
L	0045292	biological_process	mRNA cis splicing, via spliceosome
L	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL

Chain	Residue	Details
K	ALA140-LEU154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	39
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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