6O0L

crystal structure of BCL-2 G101V mutation with venetoclax

?

GO(遺伝子オントロジー)由来の情報

鎖名GO(遺伝子オントロジー)id名前空間内容
A0097136cellular_componentBcl-2 family protein complex
A0030054cellular_componentcell junction
A0005813cellular_componentcentrosome
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005783cellular_componentendoplasmic reticulum
A0016021cellular_componentintegral component of membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005741cellular_componentmitochondrial outer membrane
A0005739cellular_componentmitochondrion
A0031965cellular_componentnuclear membrane
A0030672cellular_componentsynaptic vesicle membrane
A0051434molecular_functionBH3 domain binding
A0042802molecular_functionidentical protein binding
A0046982molecular_functionprotein heterodimerization activity
A0042803molecular_functionprotein homodimerization activity
A0019901molecular_functionprotein kinase binding
A0008637biological_processapoptotic mitochondrial changes
A0071839biological_processapoptotic process in bone marrow
A0008283biological_processcell proliferation
A0060154biological_processcellular process regulating host cell cycle in response to virus
A0071312biological_processcellular response to alkaloid
A0071230biological_processcellular response to amino acid stimulus
A0071480biological_processcellular response to gamma radiation
A0019221biological_processcytokine-mediated signaling pathway
A0006897biological_processendocytosis
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0009566biological_processfertilization
A0007281biological_processgerm cell development
A0097284biological_processhepatocyte apoptotic process
A0001701biological_processin utero embryonic development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008584biological_processmale gonad development
A0070584biological_processmitochondrion morphogenesis
A0007093biological_processmitotic cell cycle checkpoint
A2000811biological_processnegative regulation of anoikis
A0043066biological_processnegative regulation of apoptotic process
A0010507biological_processnegative regulation of autophagy
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1900118biological_processnegative regulation of execution phase of apoptosis
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A0043524biological_processnegative regulation of neuron apoptotic process
A1903077biological_processnegative regulation of protein localization to plasma membrane
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0051402biological_processneuron apoptotic process
A0001541biological_processovarian follicle development
A0008284biological_processpositive regulation of cell proliferation
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
A0032465biological_processregulation of cytokinesis
A0040008biological_processregulation of growth
A0046902biological_processregulation of mitochondrial membrane permeability
A0051881biological_processregulation of mitochondrial membrane potential
A0001836biological_processrelease of cytochrome c from mitochondria
A0046898biological_processresponse to cycloheximide
A0034097biological_processresponse to cytokine
A0007283biological_processspermatogenesis
A0019050biological_processsuppression by virus of host apoptotic process
C0097136cellular_componentBcl-2 family protein complex
C0030054cellular_componentcell junction
C0005813cellular_componentcentrosome
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005783cellular_componentendoplasmic reticulum
C0016021cellular_componentintegral component of membrane
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005741cellular_componentmitochondrial outer membrane
C0005739cellular_componentmitochondrion
C0031965cellular_componentnuclear membrane
C0030672cellular_componentsynaptic vesicle membrane
C0051434molecular_functionBH3 domain binding
C0042802molecular_functionidentical protein binding
C0046982molecular_functionprotein heterodimerization activity
C0042803molecular_functionprotein homodimerization activity
C0019901molecular_functionprotein kinase binding
C0008637biological_processapoptotic mitochondrial changes
C0071839biological_processapoptotic process in bone marrow
C0008283biological_processcell proliferation
C0060154biological_processcellular process regulating host cell cycle in response to virus
C0071312biological_processcellular response to alkaloid
C0071230biological_processcellular response to amino acid stimulus
C0071480biological_processcellular response to gamma radiation
C0019221biological_processcytokine-mediated signaling pathway
C0006897biological_processendocytosis
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0009566biological_processfertilization
C0007281biological_processgerm cell development
C0097284biological_processhepatocyte apoptotic process
C0001701biological_processin utero embryonic development
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0008584biological_processmale gonad development
C0070584biological_processmitochondrion morphogenesis
C0007093biological_processmitotic cell cycle checkpoint
C2000811biological_processnegative regulation of anoikis
C0043066biological_processnegative regulation of apoptotic process
C0010507biological_processnegative regulation of autophagy
C1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C1900118biological_processnegative regulation of execution phase of apoptosis
C2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
C1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
C0043524biological_processnegative regulation of neuron apoptotic process
C1903077biological_processnegative regulation of protein localization to plasma membrane
C0090201biological_processnegative regulation of release of cytochrome c from mitochondria
C0051402biological_processneuron apoptotic process
C0001541biological_processovarian follicle development
C0008284biological_processpositive regulation of cell proliferation
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
C0032465biological_processregulation of cytokinesis
C0040008biological_processregulation of growth
C0046902biological_processregulation of mitochondrial membrane permeability
C0051881biological_processregulation of mitochondrial membrane potential
C0001836biological_processrelease of cytochrome c from mitochondria
C0046898biological_processresponse to cycloheximide
C0034097biological_processresponse to cytokine
C0007283biological_processspermatogenesis
C0019050biological_processsuppression by virus of host apoptotic process
A0005789cellular_componentendoplasmic reticulum membrane
A0016020cellular_componentmembrane
A0043209cellular_componentmyelin sheath
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0046930cellular_componentpore complex
A0032991cellular_componentprotein-containing complex
A0015267molecular_functionchannel activity
A0016248molecular_functionchannel inhibitor activity
A0002020molecular_functionprotease binding
A0051721molecular_functionprotein phosphatase 2A binding
A0070491molecular_functionrepressing transcription factor binding
A0043565molecular_functionsequence-specific DNA binding
A0031625molecular_functionubiquitin protein ligase binding
A0007015biological_processactin filament organization
A0006915biological_processapoptotic process
A0031103biological_processaxon regeneration
A0007409biological_processaxonogenesis
A0001782biological_processB cell homeostasis
A0002326biological_processB cell lineage commitment
A0042100biological_processB cell proliferation
A0050853biological_processB cell receptor signaling pathway
A0001662biological_processbehavioral fear response
A0001658biological_processbranching involved in ureteric bud morphogenesis
A0043375biological_processCD8-positive, alpha-beta T cell lineage commitment
A0007569biological_processcell aging
A0098609biological_processcell-cell adhesion
A0006974biological_processcellular response to DNA damage stimulus
A0042149biological_processcellular response to glucose starvation
A0071456biological_processcellular response to hypoxia
A0021747biological_processcochlear nucleus development
A0051607biological_processdefense response to virus
A0048546biological_processdigestive tract morphogenesis
A0043583biological_processear development
A0032469biological_processendoplasmic reticulum calcium ion homeostasis
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0007565biological_processfemale pregnancy
A0048041biological_processfocal adhesion assembly
A0022612biological_processgland morphogenesis
A0032835biological_processglomerulus development
A0031069biological_processhair follicle morphogenesis
A0048873biological_processhomeostasis of number of cells within a tissue
A0006959biological_processhumoral immune response
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
A0002320biological_processlymphoid progenitor cell differentiation
A0006582biological_processmelanin metabolic process
A0030318biological_processmelanocyte differentiation
A0014031biological_processmesenchymal cell development
A0001656biological_processmetanephros development
A2001234biological_processnegative regulation of apoptotic signaling pathway
A0010523biological_processnegative regulation of calcium ion transport into cytosol
A0030308biological_processnegative regulation of cell growth
A0030336biological_processnegative regulation of cell migration
A0032848biological_processnegative regulation of cellular pH reduction
A2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
A1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0051902biological_processnegative regulation of mitochondrial depolarization
A0033033biological_processnegative regulation of myeloid cell apoptotic process
A0030279biological_processnegative regulation of ossification
A0033689biological_processnegative regulation of osteoblast proliferation
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
A0046671biological_processnegative regulation of retinal cell programmed cell death
A0048599biological_processoocyte development
A0035265biological_processorgan growth
A0001503biological_processossification
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0048753biological_processpigment granule organization
A0030890biological_processpositive regulation of B cell proliferation
A0043085biological_processpositive regulation of catalytic activity
A0030307biological_processpositive regulation of cell growth
A0045636biological_processpositive regulation of melanocyte differentiation
A0040018biological_processpositive regulation of multicellular organism growth
A0014042biological_processpositive regulation of neuron maturation
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A1900740biological_processpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
A0048743biological_processpositive regulation of skeletal muscle fiber development
A0014911biological_processpositive regulation of smooth muscle cell migration
A0009791biological_processpost-embryonic development
A0006470biological_processprotein dephosphorylation
A0000209biological_processprotein polyubiquitination
A0072593biological_processreactive oxygen species metabolic process
A0051924biological_processregulation of calcium ion transport
A0001952biological_processregulation of cell-matrix adhesion
A0010468biological_processregulation of gene expression
A0010559biological_processregulation of glycoprotein biosynthetic process
A0006808biological_processregulation of nitrogen utilization
A0043497biological_processregulation of protein heterodimerization activity
A0043496biological_processregulation of protein homodimerization activity
A0031647biological_processregulation of protein stability
A0022898biological_processregulation of transmembrane transporter activity
A0045069biological_processregulation of viral genome replication
A0003014biological_processrenal system process
A0042493biological_processresponse to drug
A0010332biological_processresponse to gamma radiation
A0051384biological_processresponse to glucocorticoid
A0042542biological_processresponse to hydrogen peroxide
A0010039biological_processresponse to iron ion
A0002931biological_processresponse to ischemia
A0035094biological_processresponse to nicotine
A0009314biological_processresponse to radiation
A0009636biological_processresponse to toxic substance
A0010224biological_processresponse to UV-B
A0048536biological_processspleen development
A0033077biological_processT cell differentiation in thymus
A0043029biological_processT cell homeostasis
A0048538biological_processthymus development
C0005789cellular_componentendoplasmic reticulum membrane
C0016020cellular_componentmembrane
C0043209cellular_componentmyelin sheath
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0046930cellular_componentpore complex
C0032991cellular_componentprotein-containing complex
C0015267molecular_functionchannel activity
C0016248molecular_functionchannel inhibitor activity
C0002020molecular_functionprotease binding
C0051721molecular_functionprotein phosphatase 2A binding
C0070491molecular_functionrepressing transcription factor binding
C0043565molecular_functionsequence-specific DNA binding
C0031625molecular_functionubiquitin protein ligase binding
C0007015biological_processactin filament organization
C0006915biological_processapoptotic process
C0031103biological_processaxon regeneration
C0007409biological_processaxonogenesis
C0001782biological_processB cell homeostasis
C0002326biological_processB cell lineage commitment
C0042100biological_processB cell proliferation
C0050853biological_processB cell receptor signaling pathway
C0001662biological_processbehavioral fear response
C0001658biological_processbranching involved in ureteric bud morphogenesis
C0043375biological_processCD8-positive, alpha-beta T cell lineage commitment
C0007569biological_processcell aging
C0098609biological_processcell-cell adhesion
C0006974biological_processcellular response to DNA damage stimulus
C0042149biological_processcellular response to glucose starvation
C0071456biological_processcellular response to hypoxia
C0021747biological_processcochlear nucleus development
C0051607biological_processdefense response to virus
C0048546biological_processdigestive tract morphogenesis
C0043583biological_processear development
C0032469biological_processendoplasmic reticulum calcium ion homeostasis
C0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
C0007565biological_processfemale pregnancy
C0048041biological_processfocal adhesion assembly
C0022612biological_processgland morphogenesis
C0032835biological_processglomerulus development
C0031069biological_processhair follicle morphogenesis
C0048873biological_processhomeostasis of number of cells within a tissue
C0006959biological_processhumoral immune response
C0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
C0002320biological_processlymphoid progenitor cell differentiation
C0006582biological_processmelanin metabolic process
C0030318biological_processmelanocyte differentiation
C0014031biological_processmesenchymal cell development
C0001656biological_processmetanephros development
C2001234biological_processnegative regulation of apoptotic signaling pathway
C0010523biological_processnegative regulation of calcium ion transport into cytosol
C0030308biological_processnegative regulation of cell growth
C0030336biological_processnegative regulation of cell migration
C0032848biological_processnegative regulation of cellular pH reduction
C2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
C1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C0051902biological_processnegative regulation of mitochondrial depolarization
C0033033biological_processnegative regulation of myeloid cell apoptotic process
C0030279biological_processnegative regulation of ossification
C0033689biological_processnegative regulation of osteoblast proliferation
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
C0046671biological_processnegative regulation of retinal cell programmed cell death
C0048599biological_processoocyte development
C0035265biological_processorgan growth
C0001503biological_processossification
C0018105biological_processpeptidyl-serine phosphorylation
C0018107biological_processpeptidyl-threonine phosphorylation
C0048753biological_processpigment granule organization
C0030890biological_processpositive regulation of B cell proliferation
C0043085biological_processpositive regulation of catalytic activity
C0030307biological_processpositive regulation of cell growth
C0045636biological_processpositive regulation of melanocyte differentiation
C0040018biological_processpositive regulation of multicellular organism growth
C0014042biological_processpositive regulation of neuron maturation
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C1900740biological_processpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
C0048743biological_processpositive regulation of skeletal muscle fiber development
C0014911biological_processpositive regulation of smooth muscle cell migration
C0009791biological_processpost-embryonic development
C0006470biological_processprotein dephosphorylation
C0000209biological_processprotein polyubiquitination
C0072593biological_processreactive oxygen species metabolic process
C0051924biological_processregulation of calcium ion transport
C0001952biological_processregulation of cell-matrix adhesion
C0010468biological_processregulation of gene expression
C0010559biological_processregulation of glycoprotein biosynthetic process
C0006808biological_processregulation of nitrogen utilization
C0043497biological_processregulation of protein heterodimerization activity
C0043496biological_processregulation of protein homodimerization activity
C0031647biological_processregulation of protein stability
C0022898biological_processregulation of transmembrane transporter activity
C0045069biological_processregulation of viral genome replication
C0003014biological_processrenal system process
C0042493biological_processresponse to drug
C0010332biological_processresponse to gamma radiation
C0051384biological_processresponse to glucocorticoid
C0042542biological_processresponse to hydrogen peroxide
C0010039biological_processresponse to iron ion
C0002931biological_processresponse to ischemia
C0035094biological_processresponse to nicotine
C0009314biological_processresponse to radiation
C0009636biological_processresponse to toxic substance
C0010224biological_processresponse to UV-B
C0048536biological_processspleen development
C0033077biological_processT cell differentiation in thymus
C0043029biological_processT cell homeostasis
C0048538biological_processthymus development
?

PDBデータベースに由来する情報

site_id残基数詳細
AC117binding site for residue LBM A 301
鎖名残基
AARG12
AALA100
AASP103
AARG107
ATYR108
ALEU137
ATRP144
AGLY145
AVAL148
AALA149
AGLU152
APHE153
AVAL156
APHE198
ATYR202
APEG303
AHOH403

AC23binding site for residue PEG A 302
鎖名残基
AARG12
AMET16
APEG303

AC35binding site for residue PEG A 303
鎖名残基
AASN143
ATHR178
ALBM301
APEG302
ACL304

AC44binding site for residue CL A 304
鎖名残基
AGLU179
AASN182
AARG183
APEG303

AC519binding site for residue LBM C 301
鎖名残基
CARG12
CALA100
CASP103
CARG107
CTYR108
CGLU136
CLEU137
CTRP144
CGLY145
CVAL148
CALA149
CGLU152
CPHE153
CVAL156
CPHE198
CTYR202
CPEG303
CHOH401
CHOH404

AC62binding site for residue PEG C 302
鎖名残基
CARG12
CPEG303

AC76binding site for residue PEG C 303
鎖名残基
CARG12
CASN143
CARG146
CLBM301
CPEG302
CCL304

AC84binding site for residue CL C 304
鎖名残基
CGLU179
CASN182
CARG183
CPEG303

?

「HETATM」原子の座標から抽出されたリガンド結合部位

site_id残基数詳細
PEG_6o0l_A_3028DI(HYDROXYETHYL)ETHER binding site
鎖名残基ligand
AARG12PEG: DI(HYDROXYETHYL)ETHER
AMET16PEG: DI(HYDROXYETHYL)ETHER
ATRP30PEG: DI(HYDROXYETHYL)ETHER
AALA32PEG: DI(HYDROXYETHYL)ETHER
AASP171PEG: DI(HYDROXYETHYL)ETHER
AALA174-LEU175PEG: DI(HYDROXYETHYL)ETHER
ATHR178PEG: DI(HYDROXYETHYL)ETHER

PEG_6o0l_A_3035DI(HYDROXYETHYL)ETHER binding site
鎖名残基ligand
AARG12PEG: DI(HYDROXYETHYL)ETHER
ALEU175PEG: DI(HYDROXYETHYL)ETHER
ATHR178PEG: DI(HYDROXYETHYL)ETHER
AASN182-ARG183PEG: DI(HYDROXYETHYL)ETHER

LBM_6o0l_A_301234-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide binding site
鎖名残基ligand
AGLN99-ALA100LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AASP103-PHE104LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AARG107-TYR108LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AASP111-PHE112LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AMET115LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AVAL133LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AGLU136-LEU137LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AASN143-ARG146LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AVAL148-ALA149LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AGLU152-PHE153LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
AVAL156LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
APHE198LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
ATYR202LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide

PEG_6o0l_C_3027DI(HYDROXYETHYL)ETHER binding site
鎖名残基ligand
CARG12PEG: DI(HYDROXYETHYL)ETHER
CMET16PEG: DI(HYDROXYETHYL)ETHER
CTRP30PEG: DI(HYDROXYETHYL)ETHER
CALA32PEG: DI(HYDROXYETHYL)ETHER
CALA174-LEU175PEG: DI(HYDROXYETHYL)ETHER
CTHR178PEG: DI(HYDROXYETHYL)ETHER

PEG_6o0l_C_3036DI(HYDROXYETHYL)ETHER binding site
鎖名残基ligand
CARG12PEG: DI(HYDROXYETHYL)ETHER
CLEU175PEG: DI(HYDROXYETHYL)ETHER
CTHR178-GLU179PEG: DI(HYDROXYETHYL)ETHER
CASN182-ARG183PEG: DI(HYDROXYETHYL)ETHER

LBM_6o0l_C_301234-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide binding site
鎖名残基ligand
CGLN99-ALA100LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CASP103-PHE104LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CARG107-TYR108LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CASP111-PHE112LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CMET115LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CVAL133LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CGLU136-LEU137LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CASN143-ARG146LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CVAL148-ALA149LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CGLU152-PHE153LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CVAL156LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CPHE198LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
CTYR202LBM: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide

?

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id残基数詳細
?

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id残基数詳細
?

CSAにおける酵素触媒機能の情報

site_id残基数詳細