6NE5
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer
GO（遺伝子オントロジー）由来の情報
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 20 |
| 詳細 | binding site for residue KJP A 400 |
| 鎖名 | 残基 |
| A | HIS224 |
| A | VAL258 |
| A | ASN260 |
| A | ARG263 |
| A | LEU267 |
| A | PHE270 |
| A | GLY271 |
| A | ILE294 |
| A | HOH509 |
| A | HOH517 |
| A | HOH541 |
| A | ALA227 |
| C | HIS320 |
| A | PHE228 |
| A | MET231 |
| A | VAL249 |
| A | MET250 |
| A | VAL253 |
| A | PHE254 |
| A | ASP256 |
| site_id | AC2 |
| 残基数 | 18 |
| 詳細 | binding site for residue KJP B 400 |
| 鎖名 | 残基 |
| B | ALA227 |
| B | PHE228 |
| B | MET231 |
| B | LEU246 |
| B | MET250 |
| B | VAL253 |
| B | PHE254 |
| B | VAL258 |
| B | ASN260 |
| B | GLY262 |
| B | ARG263 |
| B | LEU267 |
| B | PHE270 |
| B | GLY271 |
| B | ILE294 |
| B | HOH507 |
| B | HOH515 |
| B | HOH518 |
| site_id | AC3 |
| 残基数 | 18 |
| 詳細 | binding site for residue KJP C 400 |
| 鎖名 | 残基 |
| C | HIS224 |
| C | ALA227 |
| C | PHE228 |
| C | MET231 |
| C | MET250 |
| C | VAL253 |
| C | PHE254 |
| C | ASP256 |
| C | VAL258 |
| C | ASN260 |
| C | GLY262 |
| C | ARG263 |
| C | LEU267 |
| C | PHE270 |
| C | GLY271 |
| C | ILE294 |
| C | HOH514 |
| C | HOH529 |
| site_id | AC4 |
| 残基数 | 16 |
| 詳細 | binding site for residue KJP D 400 |
| 鎖名 | 残基 |
| D | ALA227 |
| D | PHE228 |
| D | MET231 |
| D | LEU246 |
| D | MET250 |
| D | VAL253 |
| D | PHE254 |
| D | VAL258 |
| D | ASN260 |
| D | GLY262 |
| D | ARG263 |
| D | LEU267 |
| D | PHE270 |
| D | GLY271 |
| D | ILE294 |
| D | HOH525 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS01080 |
| 残基数 | 20 |
| 詳細 | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA |
| 鎖名 | 残基 | 詳細 |
| A | VAL253-ALA272 |
| site_id | PS01258 |
| 残基数 | 12 |
| 詳細 | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV |
| 鎖名 | 残基 | 詳細 |
| A | TRP305-VAL316 |
| site_id | PS01259 |
| 残基数 | 15 |
| 詳細 | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN |
| 鎖名 | 残基 | 詳細 |
| A | ALA209-ASN223 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 12 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| 鎖名 | 残基 | 詳細 |
| A | LYS194 | |
| D | LYS194 | |
| D | LYS197 | |
| A | LYS197 | |
| B | LYS194 | |
| B | LYS197 | |
| C | LYS194 | |
| C | LYS197 |
