6MSB

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

This is a large structure.
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Functional Information from GO Data

ChainGOidnamespacecontents
B0005829cellular_componentcytosol
B0016020cellular_componentmembrane
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0022624cellular_componentproteasome accessory complex
B0000502cellular_componentproteasome complex
B0008540cellular_componentproteasome regulatory particle, base subcomplex
B0005524molecular_functionATP binding
B0016887molecular_functionATPase activity
B0036402molecular_functionproteasome-activating ATPase activity
B0003723molecular_functionRNA binding
B0017025molecular_functionTBP-class protein binding
B1901215biological_processnegative regulation of neuron death
B0043687biological_processpost-translational protein modification
B0030163biological_processprotein catabolic process
B0016579biological_processprotein deubiquitination
B0006457biological_processprotein folding
F0005829cellular_componentcytosol
F0005576cellular_componentextracellular region
F1904813cellular_componentficolin-1-rich granule lumen
F0016020cellular_componentmembrane
F0005654cellular_componentnucleoplasm
F0005634cellular_componentnucleus
F0000932cellular_componentP-body
F0022624cellular_componentproteasome accessory complex
F0000502cellular_componentproteasome complex
F0008540cellular_componentproteasome regulatory particle, base subcomplex
F0034774cellular_componentsecretory granule lumen
F0005524molecular_functionATP binding
F0016887molecular_functionATPase activity
F0042802molecular_functionidentical protein binding
F0036402molecular_functionproteasome-activating ATPase activity
F0001824biological_processblastocyst development
F0043921biological_processmodulation by host of viral transcription
F0043312biological_processneutrophil degranulation
F0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0043687biological_processpost-translational protein modification
F0030163biological_processprotein catabolic process
F0016579biological_processprotein deubiquitination
F0016032biological_processviral process
D0005829cellular_componentcytosol
D0031597cellular_componentcytosolic proteasome complex
D0016234cellular_componentinclusion body
D0016020cellular_componentmembrane
D0005654cellular_componentnucleoplasm
D0005634cellular_componentnucleus
D0022624cellular_componentproteasome accessory complex
D0000502cellular_componentproteasome complex
D0008540cellular_componentproteasome regulatory particle, base subcomplex
D0045202cellular_componentsynapse
D0005524molecular_functionATP binding
D0016887molecular_functionATPase activity
D0036402molecular_functionproteasome-activating ATPase activity
D0001824biological_processblastocyst development
D0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
D0043687biological_processpost-translational protein modification
D0030163biological_processprotein catabolic process
D0016579biological_processprotein deubiquitination
D0006508biological_processproteolysis
A0005737cellular_componentcytoplasm
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0005829cellular_componentcytosol
A0043197cellular_componentdendritic spine
A0005576cellular_componentextracellular region
A1904813cellular_componentficolin-1-rich granule lumen
A0016020cellular_componentmembrane
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0000932cellular_componentP-body
A0022624cellular_componentproteasome accessory complex
A0000502cellular_componentproteasome complex
A0008540cellular_componentproteasome regulatory particle, base subcomplex
A0034774cellular_componentsecretory granule lumen
A0005524molecular_functionATP binding
A0016887molecular_functionATPase activity
A0036402molecular_functionproteasome-activating ATPase activity
A0017025molecular_functionTBP-class protein binding
A0043312biological_processneutrophil degranulation
A0001649biological_processosteoblast differentiation
A0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
A0043687biological_processpost-translational protein modification
A0016579biological_processprotein deubiquitination
A0006511biological_processubiquitin-dependent protein catabolic process
C0072562cellular_componentblood microparticle
C0005737cellular_componentcytoplasm
C0031410cellular_componentcytoplasmic vesicle
C0005829cellular_componentcytosol
C0031597cellular_componentcytosolic proteasome complex
C0070062cellular_componentextracellular exosome
C0016234cellular_componentinclusion body
C0016020cellular_componentmembrane
C0031595cellular_componentnuclear proteasome complex
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0098794cellular_componentpostsynapse
C0022624cellular_componentproteasome accessory complex
C0000502cellular_componentproteasome complex
C0008540cellular_componentproteasome regulatory particle, base subcomplex
C0005524molecular_functionATP binding
C0016887molecular_functionATPase activity
C0036402molecular_functionproteasome-activating ATPase activity
C0017025molecular_functionTBP-class protein binding
C0031531molecular_functionthyrotropin-releasing hormone receptor binding
C0008134molecular_functiontranscription factor binding
C0050804biological_processmodulation of chemical synaptic transmission
C0043069biological_processnegative regulation of programmed cell death
C0045892biological_processnegative regulation of transcription, DNA-templated
C0090261biological_processpositive regulation of inclusion body assembly
C0045899biological_processpositive regulation of RNA polymerase II transcriptional preinitiation complex assembly
C0045893biological_processpositive regulation of transcription, DNA-templated
C0043687biological_processpost-translational protein modification
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0016579biological_processprotein deubiquitination
C0006357biological_processregulation of transcription by RNA polymerase II
L0005813cellular_componentcentrosome
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0070062cellular_componentextracellular exosome
L0005654cellular_componentnucleoplasm
L0005634cellular_componentnucleus
L0005844cellular_componentpolysome
L0000502cellular_componentproteasome complex
L0005839cellular_componentproteasome core complex
L0019773cellular_componentproteasome core complex, alpha-subunit complex
L0004175molecular_functionendopeptidase activity
L0001530molecular_functionlipopolysaccharide binding
L0003723molecular_functionRNA binding
L0004298molecular_functionthreonine-type endopeptidase activity
L0002376biological_processimmune system process
L0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
L0043687biological_processpost-translational protein modification
L0010498biological_processproteasomal protein catabolic process
L0010499biological_processproteasomal ubiquitin-independent protein catabolic process
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0016579biological_processprotein deubiquitination
l0005813cellular_componentcentrosome
l0005737cellular_componentcytoplasm
l0005829cellular_componentcytosol
l0070062cellular_componentextracellular exosome
l0005654cellular_componentnucleoplasm
l0005634cellular_componentnucleus
l0005844cellular_componentpolysome
l0000502cellular_componentproteasome complex
l0005839cellular_componentproteasome core complex
l0019773cellular_componentproteasome core complex, alpha-subunit complex
l0004175molecular_functionendopeptidase activity
l0001530molecular_functionlipopolysaccharide binding
l0003723molecular_functionRNA binding
l0004298molecular_functionthreonine-type endopeptidase activity
l0002376biological_processimmune system process
l0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
l0043687biological_processpost-translational protein modification
l0010498biological_processproteasomal protein catabolic process
l0010499biological_processproteasomal ubiquitin-independent protein catabolic process
l0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
l0016579biological_processprotein deubiquitination
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0070062cellular_componentextracellular exosome
H0005576cellular_componentextracellular region
H1904813cellular_componentficolin-1-rich granule lumen
H0005654cellular_componentnucleoplasm
H0005634cellular_componentnucleus
H0000932cellular_componentP-body
H0000502cellular_componentproteasome complex
H0005839cellular_componentproteasome core complex
H0019773cellular_componentproteasome core complex, alpha-subunit complex
H0034774cellular_componentsecretory granule lumen
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0043312biological_processneutrophil degranulation
H0043687biological_processpost-translational protein modification
H0010498biological_processproteasomal protein catabolic process
H0010499biological_processproteasomal ubiquitin-independent protein catabolic process
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0016579biological_processprotein deubiquitination
H0009615biological_processresponse to virus
h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
h0070062cellular_componentextracellular exosome
h0005576cellular_componentextracellular region
h1904813cellular_componentficolin-1-rich granule lumen
h0005654cellular_componentnucleoplasm
h0005634cellular_componentnucleus
h0000932cellular_componentP-body
h0000502cellular_componentproteasome complex
h0005839cellular_componentproteasome core complex
h0019773cellular_componentproteasome core complex, alpha-subunit complex
h0034774cellular_componentsecretory granule lumen
h0004175molecular_functionendopeptidase activity
h0004298molecular_functionthreonine-type endopeptidase activity
h0043312biological_processneutrophil degranulation
h0043687biological_processpost-translational protein modification
h0010498biological_processproteasomal protein catabolic process
h0010499biological_processproteasomal ubiquitin-independent protein catabolic process
h0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
h0016579biological_processprotein deubiquitination
h0009615biological_processresponse to virus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0070062cellular_componentextracellular exosome
M0005654cellular_componentnucleoplasm
M0005634cellular_componentnucleus
M0000502cellular_componentproteasome complex
M0005839cellular_componentproteasome core complex
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0045202cellular_componentsynapse
M0004175molecular_functionendopeptidase activity
M0004298molecular_functionthreonine-type endopeptidase activity
M0031625molecular_functionubiquitin protein ligase binding
M0043687biological_processpost-translational protein modification
M0010498biological_processproteasomal protein catabolic process
M0010499biological_processproteasomal ubiquitin-independent protein catabolic process
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0016579biological_processprotein deubiquitination
M0052548biological_processregulation of endopeptidase activity
M0016032biological_processviral process
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0070062cellular_componentextracellular exosome
m0005654cellular_componentnucleoplasm
m0005634cellular_componentnucleus
m0000502cellular_componentproteasome complex
m0005839cellular_componentproteasome core complex
m0019773cellular_componentproteasome core complex, alpha-subunit complex
m0045202cellular_componentsynapse
m0004175molecular_functionendopeptidase activity
m0004298molecular_functionthreonine-type endopeptidase activity
m0031625molecular_functionubiquitin protein ligase binding
m0043687biological_processpost-translational protein modification
m0010498biological_processproteasomal protein catabolic process
m0010499biological_processproteasomal ubiquitin-independent protein catabolic process
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m0016579biological_processprotein deubiquitination
m0052548biological_processregulation of endopeptidase activity
m0016032biological_processviral process
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0070062cellular_componentextracellular exosome
I0043231cellular_componentintracellular membrane-bounded organelle
I0005654cellular_componentnucleoplasm
I0005634cellular_componentnucleus
I0000932cellular_componentP-body
I0000502cellular_componentproteasome complex
I0005839cellular_componentproteasome core complex
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0043687biological_processpost-translational protein modification
I0010498biological_processproteasomal protein catabolic process
I0010499biological_processproteasomal ubiquitin-independent protein catabolic process
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0016579biological_processprotein deubiquitination
I0016032biological_processviral process
i0005737cellular_componentcytoplasm
i0005829cellular_componentcytosol
i0070062cellular_componentextracellular exosome
i0043231cellular_componentintracellular membrane-bounded organelle
i0005654cellular_componentnucleoplasm
i0005634cellular_componentnucleus
i0000932cellular_componentP-body
i0000502cellular_componentproteasome complex
i0005839cellular_componentproteasome core complex
i0019773cellular_componentproteasome core complex, alpha-subunit complex
i0004175molecular_functionendopeptidase activity
i0004298molecular_functionthreonine-type endopeptidase activity
i0043687biological_processpost-translational protein modification
i0010498biological_processproteasomal protein catabolic process
i0010499biological_processproteasomal ubiquitin-independent protein catabolic process
i0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
i0016579biological_processprotein deubiquitination
i0016032biological_processviral process
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0070062cellular_componentextracellular exosome
K0005576cellular_componentextracellular region
K1904813cellular_componentficolin-1-rich granule lumen
K0005654cellular_componentnucleoplasm
K0005634cellular_componentnucleus
K0000502cellular_componentproteasome complex
K0005839cellular_componentproteasome core complex
K0019773cellular_componentproteasome core complex, alpha-subunit complex
K0034774cellular_componentsecretory granule lumen
K0004175molecular_functionendopeptidase activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0043312biological_processneutrophil degranulation
K0043687biological_processpost-translational protein modification
K0010498biological_processproteasomal protein catabolic process
K0010499biological_processproteasomal ubiquitin-independent protein catabolic process
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0016579biological_processprotein deubiquitination
k0005737cellular_componentcytoplasm
k0005829cellular_componentcytosol
k0070062cellular_componentextracellular exosome
k0005576cellular_componentextracellular region
k1904813cellular_componentficolin-1-rich granule lumen
k0005654cellular_componentnucleoplasm
k0005634cellular_componentnucleus
k0000502cellular_componentproteasome complex
k0005839cellular_componentproteasome core complex
k0019773cellular_componentproteasome core complex, alpha-subunit complex
k0034774cellular_componentsecretory granule lumen
k0004175molecular_functionendopeptidase activity
k0004298molecular_functionthreonine-type endopeptidase activity
k0043312biological_processneutrophil degranulation
k0043687biological_processpost-translational protein modification
k0010498biological_processproteasomal protein catabolic process
k0010499biological_processproteasomal ubiquitin-independent protein catabolic process
k0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
k0016579biological_processprotein deubiquitination
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0070062cellular_componentextracellular exosome
G0030016cellular_componentmyofibril
G0016363cellular_componentnuclear matrix
G0005654cellular_componentnucleoplasm
G0005634cellular_componentnucleus
G0000932cellular_componentP-body
G0005844cellular_componentpolysome
G0000502cellular_componentproteasome complex
G0005839cellular_componentproteasome core complex
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0030017cellular_componentsarcomere
G0004175molecular_functionendopeptidase activity
G0051059molecular_functionNF-kappaB binding
G0035639molecular_functionpurine ribonucleoside triphosphate binding
G0003723molecular_functionRNA binding
G0004298molecular_functionthreonine-type endopeptidase activity
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0043687biological_processpost-translational protein modification
G0010498biological_processproteasomal protein catabolic process
G0010499biological_processproteasomal ubiquitin-independent protein catabolic process
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0016579biological_processprotein deubiquitination
G0051603biological_processproteolysis involved in cellular protein catabolic process
G0050727biological_processregulation of inflammatory response
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0070062cellular_componentextracellular exosome
g0030016cellular_componentmyofibril
g0016363cellular_componentnuclear matrix
g0005654cellular_componentnucleoplasm
g0005634cellular_componentnucleus
g0000932cellular_componentP-body
g0005844cellular_componentpolysome
g0000502cellular_componentproteasome complex
g0005839cellular_componentproteasome core complex
g0019773cellular_componentproteasome core complex, alpha-subunit complex
g0030017cellular_componentsarcomere
g0004175molecular_functionendopeptidase activity
g0051059molecular_functionNF-kappaB binding
g0035639molecular_functionpurine ribonucleoside triphosphate binding
g0003723molecular_functionRNA binding
g0004298molecular_functionthreonine-type endopeptidase activity
g0051092biological_processpositive regulation of NF-kappaB transcription factor activity
g0043687biological_processpost-translational protein modification
g0010498biological_processproteasomal protein catabolic process
g0010499biological_processproteasomal ubiquitin-independent protein catabolic process
g0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
g0016579biological_processprotein deubiquitination
g0051603biological_processproteolysis involved in cellular protein catabolic process
g0050727biological_processregulation of inflammatory response
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0070062cellular_componentextracellular exosome
J0005654cellular_componentnucleoplasm
J0005634cellular_componentnucleus
J0098794cellular_componentpostsynapse
J0000502cellular_componentproteasome complex
J0005839cellular_componentproteasome core complex
J0019773cellular_componentproteasome core complex, alpha-subunit complex
J0004175molecular_functionendopeptidase activity
J0042802molecular_functionidentical protein binding
J0004298molecular_functionthreonine-type endopeptidase activity
J0043687biological_processpost-translational protein modification
J0010498biological_processproteasomal protein catabolic process
J0010499biological_processproteasomal ubiquitin-independent protein catabolic process
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0016579biological_processprotein deubiquitination
J0016032biological_processviral process
j0005737cellular_componentcytoplasm
j0005829cellular_componentcytosol
j0070062cellular_componentextracellular exosome
j0005654cellular_componentnucleoplasm
j0005634cellular_componentnucleus
j0098794cellular_componentpostsynapse
j0000502cellular_componentproteasome complex
j0005839cellular_componentproteasome core complex
j0019773cellular_componentproteasome core complex, alpha-subunit complex
j0004175molecular_functionendopeptidase activity
j0042802molecular_functionidentical protein binding
j0004298molecular_functionthreonine-type endopeptidase activity
j0043687biological_processpost-translational protein modification
j0010498biological_processproteasomal protein catabolic process
j0010499biological_processproteasomal ubiquitin-independent protein catabolic process
j0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
j0016579biological_processprotein deubiquitination
j0016032biological_processviral process
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0070062cellular_componentextracellular exosome
S0005576cellular_componentextracellular region
S1904813cellular_componentficolin-1-rich granule lumen
S0005654cellular_componentnucleoplasm
S0005634cellular_componentnucleus
S0000502cellular_componentproteasome complex
S0005839cellular_componentproteasome core complex
S0019774cellular_componentproteasome core complex, beta-subunit complex
S0034774cellular_componentsecretory granule lumen
S0004175molecular_functionendopeptidase activity
S0004298molecular_functionthreonine-type endopeptidase activity
S0043312biological_processneutrophil degranulation
S0043687biological_processpost-translational protein modification
S0010498biological_processproteasomal protein catabolic process
S0010499biological_processproteasomal ubiquitin-independent protein catabolic process
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0016579biological_processprotein deubiquitination
S0016032biological_processviral process
s0005737cellular_componentcytoplasm
s0005829cellular_componentcytosol
s0070062cellular_componentextracellular exosome
s0005576cellular_componentextracellular region
s1904813cellular_componentficolin-1-rich granule lumen
s0005654cellular_componentnucleoplasm
s0005634cellular_componentnucleus
s0000502cellular_componentproteasome complex
s0005839cellular_componentproteasome core complex
s0019774cellular_componentproteasome core complex, beta-subunit complex
s0034774cellular_componentsecretory granule lumen
s0004175molecular_functionendopeptidase activity
s0004298molecular_functionthreonine-type endopeptidase activity
s0043312biological_processneutrophil degranulation
s0043687biological_processpost-translational protein modification
s0010498biological_processproteasomal protein catabolic process
s0010499biological_processproteasomal ubiquitin-independent protein catabolic process
s0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
s0016579biological_processprotein deubiquitination
s0016032biological_processviral process
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0070062cellular_componentextracellular exosome
Q0016020cellular_componentmembrane
Q0005654cellular_componentnucleoplasm
Q0005634cellular_componentnucleus
Q0000502cellular_componentproteasome complex
Q0005839cellular_componentproteasome core complex
Q0019774cellular_componentproteasome core complex, beta-subunit complex
Q0004175molecular_functionendopeptidase activity
Q0004298molecular_functionthreonine-type endopeptidase activity
Q0043687biological_processpost-translational protein modification
Q0010498biological_processproteasomal protein catabolic process
Q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0016579biological_processprotein deubiquitination
Q0014070biological_processresponse to organic cyclic compound
Q0010243biological_processresponse to organonitrogen compound
Q0016032biological_processviral process
q0005737cellular_componentcytoplasm
q0005829cellular_componentcytosol
q0070062cellular_componentextracellular exosome
q0016020cellular_componentmembrane
q0005654cellular_componentnucleoplasm
q0005634cellular_componentnucleus
q0000502cellular_componentproteasome complex
q0005839cellular_componentproteasome core complex
q0019774cellular_componentproteasome core complex, beta-subunit complex
q0004175molecular_functionendopeptidase activity
q0004298molecular_functionthreonine-type endopeptidase activity
q0043687biological_processpost-translational protein modification
q0010498biological_processproteasomal protein catabolic process
q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
q0016579biological_processprotein deubiquitination
q0014070biological_processresponse to organic cyclic compound
q0010243biological_processresponse to organonitrogen compound
q0016032biological_processviral process
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0070062cellular_componentextracellular exosome
P0005654cellular_componentnucleoplasm
P0005634cellular_componentnucleus
P0000502cellular_componentproteasome complex
P0005839cellular_componentproteasome core complex
P0019774cellular_componentproteasome core complex, beta-subunit complex
P0004175molecular_functionendopeptidase activity
P0004298molecular_functionthreonine-type endopeptidase activity
P0043687biological_processpost-translational protein modification
P0010498biological_processproteasomal protein catabolic process
P0010499biological_processproteasomal ubiquitin-independent protein catabolic process
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0016579biological_processprotein deubiquitination
P0016032biological_processviral process
p0005737cellular_componentcytoplasm
p0005829cellular_componentcytosol
p0070062cellular_componentextracellular exosome
p0005654cellular_componentnucleoplasm
p0005634cellular_componentnucleus
p0000502cellular_componentproteasome complex
p0005839cellular_componentproteasome core complex
p0019774cellular_componentproteasome core complex, beta-subunit complex
p0004175molecular_functionendopeptidase activity
p0004298molecular_functionthreonine-type endopeptidase activity
p0043687biological_processpost-translational protein modification
p0010498biological_processproteasomal protein catabolic process
p0010499biological_processproteasomal ubiquitin-independent protein catabolic process
p0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
p0016579biological_processprotein deubiquitination
p0016032biological_processviral process
T0005737cellular_componentcytoplasm
T0005829cellular_componentcytosol
T0070062cellular_componentextracellular exosome
T0005654cellular_componentnucleoplasm
T0005634cellular_componentnucleus
T0000502cellular_componentproteasome complex
T0005839cellular_componentproteasome core complex
T0019774cellular_componentproteasome core complex, beta-subunit complex
T0004175molecular_functionendopeptidase activity
T0001530molecular_functionlipopolysaccharide binding
T0004298molecular_functionthreonine-type endopeptidase activity
T0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
T0043687biological_processpost-translational protein modification
T0010498biological_processproteasomal protein catabolic process
T0010499biological_processproteasomal ubiquitin-independent protein catabolic process
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0016579biological_processprotein deubiquitination
T0016032biological_processviral process
t0005737cellular_componentcytoplasm
t0005829cellular_componentcytosol
t0070062cellular_componentextracellular exosome
t0005654cellular_componentnucleoplasm
t0005634cellular_componentnucleus
t0000502cellular_componentproteasome complex
t0005839cellular_componentproteasome core complex
t0019774cellular_componentproteasome core complex, beta-subunit complex
t0004175molecular_functionendopeptidase activity
t0001530molecular_functionlipopolysaccharide binding
t0004298molecular_functionthreonine-type endopeptidase activity
t0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
t0043687biological_processpost-translational protein modification
t0010498biological_processproteasomal protein catabolic process
t0010499biological_processproteasomal ubiquitin-independent protein catabolic process
t0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
t0016579biological_processprotein deubiquitination
t0016032biological_processviral process
R0005813cellular_componentcentrosome
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0070062cellular_componentextracellular exosome
R0005654cellular_componentnucleoplasm
R0005634cellular_componentnucleus
R0000502cellular_componentproteasome complex
R0005839cellular_componentproteasome core complex
R0019774cellular_componentproteasome core complex, beta-subunit complex
R0004175molecular_functionendopeptidase activity
R0008233molecular_functionpeptidase activity
R0004298molecular_functionthreonine-type endopeptidase activity
R0043687biological_processpost-translational protein modification
R0010498biological_processproteasomal protein catabolic process
R0010499biological_processproteasomal ubiquitin-independent protein catabolic process
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0016579biological_processprotein deubiquitination
R0006508biological_processproteolysis
R0006979biological_processresponse to oxidative stress
R0016032biological_processviral process
r0005813cellular_componentcentrosome
r0005737cellular_componentcytoplasm
r0005829cellular_componentcytosol
r0070062cellular_componentextracellular exosome
r0005654cellular_componentnucleoplasm
r0005634cellular_componentnucleus
r0000502cellular_componentproteasome complex
r0005839cellular_componentproteasome core complex
r0019774cellular_componentproteasome core complex, beta-subunit complex
r0004175molecular_functionendopeptidase activity
r0008233molecular_functionpeptidase activity
r0004298molecular_functionthreonine-type endopeptidase activity
r0043687biological_processpost-translational protein modification
r0010498biological_processproteasomal protein catabolic process
r0010499biological_processproteasomal ubiquitin-independent protein catabolic process
r0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
r0016579biological_processprotein deubiquitination
r0006508biological_processproteolysis
r0006979biological_processresponse to oxidative stress
r0016032biological_processviral process
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0070062cellular_componentextracellular exosome
N0005654cellular_componentnucleoplasm
N0005634cellular_componentnucleus
N0000502cellular_componentproteasome complex
N0005839cellular_componentproteasome core complex
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0045296molecular_functioncadherin binding
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0043687biological_processpost-translational protein modification
N0010498biological_processproteasomal protein catabolic process
N0010499biological_processproteasomal ubiquitin-independent protein catabolic process
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0016579biological_processprotein deubiquitination
N0016032biological_processviral process
n0005737cellular_componentcytoplasm
n0005829cellular_componentcytosol
n0070062cellular_componentextracellular exosome
n0005654cellular_componentnucleoplasm
n0005634cellular_componentnucleus
n0000502cellular_componentproteasome complex
n0005839cellular_componentproteasome core complex
n0019774cellular_componentproteasome core complex, beta-subunit complex
n0045296molecular_functioncadherin binding
n0004175molecular_functionendopeptidase activity
n0004298molecular_functionthreonine-type endopeptidase activity
n0043687biological_processpost-translational protein modification
n0010498biological_processproteasomal protein catabolic process
n0010499biological_processproteasomal ubiquitin-independent protein catabolic process
n0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
n0016579biological_processprotein deubiquitination
n0016032biological_processviral process
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005576cellular_componentextracellular region
O1904813cellular_componentficolin-1-rich granule lumen
O0005654cellular_componentnucleoplasm
O0005634cellular_componentnucleus
O0000502cellular_componentproteasome complex
O0005839cellular_componentproteasome core complex
O0019774cellular_componentproteasome core complex, beta-subunit complex
O0034774cellular_componentsecretory granule lumen
O0004175molecular_functionendopeptidase activity
O0004298molecular_functionthreonine-type endopeptidase activity
O0043312biological_processneutrophil degranulation
O0043687biological_processpost-translational protein modification
O0010498biological_processproteasomal protein catabolic process
O0010499biological_processproteasomal ubiquitin-independent protein catabolic process
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0016579biological_processprotein deubiquitination
O0016032biological_processviral process
o0005737cellular_componentcytoplasm
o0005829cellular_componentcytosol
o0005576cellular_componentextracellular region
o1904813cellular_componentficolin-1-rich granule lumen
o0005654cellular_componentnucleoplasm
o0005634cellular_componentnucleus
o0000502cellular_componentproteasome complex
o0005839cellular_componentproteasome core complex
o0019774cellular_componentproteasome core complex, beta-subunit complex
o0034774cellular_componentsecretory granule lumen
o0004175molecular_functionendopeptidase activity
o0004298molecular_functionthreonine-type endopeptidase activity
o0043312biological_processneutrophil degranulation
o0043687biological_processpost-translational protein modification
o0010498biological_processproteasomal protein catabolic process
o0010499biological_processproteasomal ubiquitin-independent protein catabolic process
o0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
o0016579biological_processprotein deubiquitination
o0016032biological_processviral process
X0005829cellular_componentcytosol
X0005576cellular_componentextracellular region
X1904813cellular_componentficolin-1-rich granule lumen
X0016020cellular_componentmembrane
X0005654cellular_componentnucleoplasm
X0005634cellular_componentnucleus
X0022624cellular_componentproteasome accessory complex
X0000502cellular_componentproteasome complex
X0008541cellular_componentproteasome regulatory particle, lid subcomplex
X0034774cellular_componentsecretory granule lumen
X0005198molecular_functionstructural molecule activity
X0043312biological_processneutrophil degranulation
X0043687biological_processpost-translational protein modification
X0043248biological_processproteasome assembly
X0016579biological_processprotein deubiquitination
X0048863biological_processstem cell differentiation
X0006511biological_processubiquitin-dependent protein catabolic process
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0070062cellular_componentextracellular exosome
W0005576cellular_componentextracellular region
W1904813cellular_componentficolin-1-rich granule lumen
W0016020cellular_componentmembrane
W0031595cellular_componentnuclear proteasome complex
W0005654cellular_componentnucleoplasm
W0022624cellular_componentproteasome accessory complex
W0000502cellular_componentproteasome complex
W0005838cellular_componentproteasome regulatory particle
W0008541cellular_componentproteasome regulatory particle, lid subcomplex
W0034774cellular_componentsecretory granule lumen
W0043312biological_processneutrophil degranulation
W0043687biological_processpost-translational protein modification
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0016579biological_processprotein deubiquitination
a0005829cellular_componentcytosol
a0005576cellular_componentextracellular region
a1904813cellular_componentficolin-1-rich granule lumen
a0016020cellular_componentmembrane
a0005654cellular_componentnucleoplasm
a0005634cellular_componentnucleus
a0022624cellular_componentproteasome accessory complex
a0000502cellular_componentproteasome complex
a0005838cellular_componentproteasome regulatory particle
a0008541cellular_componentproteasome regulatory particle, lid subcomplex
a0034774cellular_componentsecretory granule lumen
a0005198molecular_functionstructural molecule activity
a0007127biological_processmeiosis I
a0043312biological_processneutrophil degranulation
a0043687biological_processpost-translational protein modification
a0043248biological_processproteasome assembly
a0016579biological_processprotein deubiquitination
a0006511biological_processubiquitin-dependent protein catabolic process
c0005829cellular_componentcytosol
c0031597cellular_componentcytosolic proteasome complex
c0005576cellular_componentextracellular region
c1904813cellular_componentficolin-1-rich granule lumen
c0005654cellular_componentnucleoplasm
c0005634cellular_componentnucleus
c0022624cellular_componentproteasome accessory complex
c0000502cellular_componentproteasome complex
c0008541cellular_componentproteasome regulatory particle, lid subcomplex
c0034774cellular_componentsecretory granule lumen
c0061133molecular_functionendopeptidase activator activity
c0061578molecular_functionLys63-specific deubiquitinase activity
c0046872molecular_functionmetal ion binding
c0008237molecular_functionmetallopeptidase activity
c0070628molecular_functionproteasome binding
c0004843molecular_functionthiol-dependent ubiquitin-specific protease activity
c0036459molecular_functionthiol-dependent ubiquitinyl hydrolase activity
c0000724biological_processdouble-strand break repair via homologous recombination
c0006303biological_processdouble-strand break repair via nonhomologous end joining
c0043312biological_processneutrophil degranulation
c0043687biological_processpost-translational protein modification
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0016579biological_processprotein deubiquitination
c0070536biological_processprotein K63-linked deubiquitination
c0061136biological_processregulation of proteasomal protein catabolic process
c0045471biological_processresponse to ethanol
c0006511biological_processubiquitin-dependent protein catabolic process
U0035578cellular_componentazurophil granule lumen
U0005829cellular_componentcytosol
U0005576cellular_componentextracellular region
U0016020cellular_componentmembrane
U0005654cellular_componentnucleoplasm
U0005634cellular_componentnucleus
U0022624cellular_componentproteasome accessory complex
U0000502cellular_componentproteasome complex
U0005838cellular_componentproteasome regulatory particle
U0008540cellular_componentproteasome regulatory particle, base subcomplex
U0034515cellular_componentproteasome storage granule
U0030234molecular_functionenzyme regulator activity
U0031625molecular_functionubiquitin protein ligase binding
U0043312biological_processneutrophil degranulation
U0043687biological_processpost-translational protein modification
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0016579biological_processprotein deubiquitination
U0042176biological_processregulation of protein catabolic process
f0005829cellular_componentcytosol
f0070062cellular_componentextracellular exosome
f0005576cellular_componentextracellular region
f1904813cellular_componentficolin-1-rich granule lumen
f0016020cellular_componentmembrane
f0005654cellular_componentnucleoplasm
f0005634cellular_componentnucleus
f0022624cellular_componentproteasome accessory complex
f0000502cellular_componentproteasome complex
f0005838cellular_componentproteasome regulatory particle
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0034515cellular_componentproteasome storage granule
f0034774cellular_componentsecretory granule lumen
f0030234molecular_functionenzyme regulator activity
f0043312biological_processneutrophil degranulation
f0043687biological_processpost-translational protein modification
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0016579biological_processprotein deubiquitination
f0042176biological_processregulation of protein catabolic process
V0005829cellular_componentcytosol
V0070062cellular_componentextracellular exosome
V0005576cellular_componentextracellular region
V1904813cellular_componentficolin-1-rich granule lumen
V0016020cellular_componentmembrane
V0005654cellular_componentnucleoplasm
V0005634cellular_componentnucleus
V0022624cellular_componentproteasome accessory complex
V0000502cellular_componentproteasome complex
V0008541cellular_componentproteasome regulatory particle, lid subcomplex
V0034774cellular_componentsecretory granule lumen
V0030234molecular_functionenzyme regulator activity
V0043312biological_processneutrophil degranulation
V0043687biological_processpost-translational protein modification
V0016579biological_processprotein deubiquitination
V0042176biological_processregulation of protein catabolic process
V0006511biological_processubiquitin-dependent protein catabolic process
b0005829cellular_componentcytosol
b0005654cellular_componentnucleoplasm
b0005634cellular_componentnucleus
b0022624cellular_componentproteasome accessory complex
b0000502cellular_componentproteasome complex
b0008540cellular_componentproteasome regulatory particle, base subcomplex
b0042802molecular_functionidentical protein binding
b0031593molecular_functionpolyubiquitin modification-dependent protein binding
b0003723molecular_functionRNA binding
b0043687biological_processpost-translational protein modification
b0043248biological_processproteasome assembly
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0016579biological_processprotein deubiquitination
Y0005829cellular_componentcytosol
Y0005576cellular_componentextracellular region
Y1904813cellular_componentficolin-1-rich granule lumen
Y0005654cellular_componentnucleoplasm
Y0022624cellular_componentproteasome accessory complex
Y0000502cellular_componentproteasome complex
Y0005838cellular_componentproteasome regulatory particle
Y0034774cellular_componentsecretory granule lumen
Y0016887molecular_functionATPase activity
Y0030234molecular_functionenzyme regulator activity
Y0043312biological_processneutrophil degranulation
Y0043687biological_processpost-translational protein modification
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0016579biological_processprotein deubiquitination
Y0006508biological_processproteolysis
Z0005829cellular_componentcytosol
Z0070062cellular_componentextracellular exosome
Z0005576cellular_componentextracellular region
Z1904813cellular_componentficolin-1-rich granule lumen
Z0016020cellular_componentmembrane
Z0005654cellular_componentnucleoplasm
Z0005634cellular_componentnucleus
Z0000502cellular_componentproteasome complex
Z0005838cellular_componentproteasome regulatory particle
Z0034774cellular_componentsecretory granule lumen
Z0042803molecular_functionprotein homodimerization activity
Z0043312biological_processneutrophil degranulation
Z0043687biological_processpost-translational protein modification
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0016579biological_processprotein deubiquitination
d0005829cellular_componentcytosol
d0005654cellular_componentnucleoplasm
d0005634cellular_componentnucleus
d0022624cellular_componentproteasome accessory complex
d0000502cellular_componentproteasome complex
d0005838cellular_componentproteasome regulatory particle
d0008541cellular_componentproteasome regulatory particle, lid subcomplex
d0043687biological_processpost-translational protein modification
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
d0016579biological_processprotein deubiquitination
e0005829cellular_componentcytosol
e0005654cellular_componentnucleoplasm
e0000502cellular_componentproteasome complex
e0008541cellular_componentproteasome regulatory particle, lid subcomplex
e0000724biological_processdouble-strand break repair via homologous recombination
e0006406biological_processmRNA export from nucleus
e0043687biological_processpost-translational protein modification
e0043248biological_processproteasome assembly
e0016579biological_processprotein deubiquitination
u0005737cellular_componentcytoplasm
u0005829cellular_componentcytosol
u0030666cellular_componentendocytic vesicle membrane
u0005789cellular_componentendoplasmic reticulum membrane
u0010008cellular_componentendosome membrane
u0070062cellular_componentextracellular exosome
u0005615cellular_componentextracellular space
u0043657cellular_componenthost cell
u0005741cellular_componentmitochondrial outer membrane
u0005739cellular_componentmitochondrion
u0043005cellular_componentneuron projection
u0043025cellular_componentneuronal cell body
u0005654cellular_componentnucleoplasm
u0005634cellular_componentnucleus
u0005886cellular_componentplasma membrane
u0031982cellular_componentvesicle
u0031386molecular_functionprotein tag
u0031625molecular_functionubiquitin protein ligase binding
u0000187biological_processactivation of MAPK activity
u0031145biological_processanaphase-promoting complex-dependent catabolic process
u0044267biological_processcellular protein metabolic process
u0019221biological_processcytokine-mediated signaling pathway
u0042769biological_processDNA damage response, detection of DNA damage
u0016197biological_processendosomal transport
u0097009biological_processenergy homeostasis
u0070987biological_processerror-free translesion synthesis
u0042276biological_processerror-prone translesion synthesis
u0060613biological_processfat pad development
u0008585biological_processfemale gonad development
u0007144biological_processfemale meiosis I
u0070911biological_processglobal genome nucleotide-excision repair
u0021888biological_processhypothalamus gonadotrophin-releasing hormone neuron development
u0007249biological_processI-kappaB kinase/NF-kappaB signaling
u0070498biological_processinterleukin-1-mediated signaling pathway
u0036297biological_processinterstrand cross-link repair
u0075733biological_processintracellular transport of virus
u0007254biological_processJNK cascade
u0007141biological_processmale meiosis I
u0061024biological_processmembrane organization
u0047497biological_processmitochondrion transport along microtubule
u0019941biological_processmodification-dependent protein catabolic process
u0002755biological_processMyD88-dependent toll-like receptor signaling pathway
u0043066biological_processnegative regulation of apoptotic process
u0000122biological_processnegative regulation of transcription by RNA polymerase II
u0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
u0048812biological_processneuron projection morphogenesis
u0070423biological_processnucleotide-binding oligomerization domain containing signaling pathway
u0000715biological_processnucleotide-excision repair, DNA damage recognition
u0006297biological_processnucleotide-excision repair, DNA gap filling
u0033683biological_processnucleotide-excision repair, DNA incision
u0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
u0006294biological_processnucleotide-excision repair, preincision complex assembly
u0043065biological_processpositive regulation of apoptotic process
u1902255biological_processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
u0051092biological_processpositive regulation of NF-kappaB transcription factor activity
u1902527biological_processpositive regulation of protein monoubiquitination
u0031398biological_processpositive regulation of protein ubiquitination
u0045944biological_processpositive regulation of transcription by RNA polymerase II
u0016579biological_processprotein deubiquitination
u0000209biological_processprotein polyubiquitination
u0006625biological_processprotein targeting to peroxisome
u0016567biological_processprotein ubiquitination
u0051881biological_processregulation of mitochondrial membrane potential
u0043488biological_processregulation of mRNA stability
u1901214biological_processregulation of neuron death
u0061136biological_processregulation of proteasomal protein catabolic process
u0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
u0072520biological_processseminiferous tubule development
u0051403biological_processstress-activated MAPK cascade
u0006283biological_processtranscription-coupled nucleotide-excision repair
u0007179biological_processtransforming growth factor beta receptor signaling pathway
u0019985biological_processtranslesion synthesis
u0055085biological_processtransmembrane transport
u0035666biological_processTRIF-dependent toll-like receptor signaling pathway
u0019058biological_processviral life cycle
u0019068biological_processvirion assembly
u0016055biological_processWnt signaling pathway
w0005737cellular_componentcytoplasm
w0005829cellular_componentcytosol
w0030666cellular_componentendocytic vesicle membrane
w0005789cellular_componentendoplasmic reticulum membrane
w0010008cellular_componentendosome membrane
w0070062cellular_componentextracellular exosome
w0005615cellular_componentextracellular space
w0043657cellular_componenthost cell
w0005741cellular_componentmitochondrial outer membrane
w0005739cellular_componentmitochondrion
w0043005cellular_componentneuron projection
w0043025cellular_componentneuronal cell body
w0005654cellular_componentnucleoplasm
w0005634cellular_componentnucleus
w0005886cellular_componentplasma membrane
w0031982cellular_componentvesicle
w0031386molecular_functionprotein tag
w0031625molecular_functionubiquitin protein ligase binding
w0000187biological_processactivation of MAPK activity
w0031145biological_processanaphase-promoting complex-dependent catabolic process
w0044267biological_processcellular protein metabolic process
w0019221biological_processcytokine-mediated signaling pathway
w0042769biological_processDNA damage response, detection of DNA damage
w0016197biological_processendosomal transport
w0097009biological_processenergy homeostasis
w0070987biological_processerror-free translesion synthesis
w0042276biological_processerror-prone translesion synthesis
w0060613biological_processfat pad development
w0008585biological_processfemale gonad development
w0007144biological_processfemale meiosis I
w0070911biological_processglobal genome nucleotide-excision repair
w0021888biological_processhypothalamus gonadotrophin-releasing hormone neuron development
w0007249biological_processI-kappaB kinase/NF-kappaB signaling
w0070498biological_processinterleukin-1-mediated signaling pathway
w0036297biological_processinterstrand cross-link repair
w0075733biological_processintracellular transport of virus
w0007254biological_processJNK cascade
w0007141biological_processmale meiosis I
w0061024biological_processmembrane organization
w0047497biological_processmitochondrion transport along microtubule
w0019941biological_processmodification-dependent protein catabolic process
w0002755biological_processMyD88-dependent toll-like receptor signaling pathway
w0043066biological_processnegative regulation of apoptotic process
w0000122biological_processnegative regulation of transcription by RNA polymerase II
w0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
w0048812biological_processneuron projection morphogenesis
w0070423biological_processnucleotide-binding oligomerization domain containing signaling pathway
w0000715biological_processnucleotide-excision repair, DNA damage recognition
w0006297biological_processnucleotide-excision repair, DNA gap filling
w0033683biological_processnucleotide-excision repair, DNA incision
w0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
w0006294biological_processnucleotide-excision repair, preincision complex assembly
w0043065biological_processpositive regulation of apoptotic process
w1902255biological_processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
w0051092biological_processpositive regulation of NF-kappaB transcription factor activity
w1902527biological_processpositive regulation of protein monoubiquitination
w0031398biological_processpositive regulation of protein ubiquitination
w0045944biological_processpositive regulation of transcription by RNA polymerase II
w0016579biological_processprotein deubiquitination
w0000209biological_processprotein polyubiquitination
w0006625biological_processprotein targeting to peroxisome
w0016567biological_processprotein ubiquitination
w0051881biological_processregulation of mitochondrial membrane potential
w0043488biological_processregulation of mRNA stability
w1901214biological_processregulation of neuron death
w0061136biological_processregulation of proteasomal protein catabolic process
w0061418biological_processregulation of transcription from RNA polymerase II promoter in response to hypoxia
w0072520biological_processseminiferous tubule development
w0051403biological_processstress-activated MAPK cascade
w0006283biological_processtranscription-coupled nucleotide-excision repair
w0007179biological_processtransforming growth factor beta receptor signaling pathway
w0019985biological_processtranslesion synthesis
w0055085biological_processtransmembrane transport
w0035666biological_processTRIF-dependent toll-like receptor signaling pathway
w0019058biological_processviral life cycle
w0019068biological_processvirion assembly
w0016055biological_processWnt signaling pathway
E0031597cellular_componentcytosolic proteasome complex
E0016234cellular_componentinclusion body
E0022624cellular_componentproteasome accessory complex
E0005524molecular_functionATP binding
E0036402molecular_functionproteasome-activating ATPase activity
E0090261biological_processpositive regulation of inclusion body assembly
E0030163biological_processprotein catabolic process
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14binding site for residue ZN c 401
ChainResidue
cGLU52
cHIS113
cHIS115
cASP126

AC214binding site for residue ATP A 501
ChainResidue
AASP176
AGLY178
APRO218
AGLY219
ATHR220
AGLY221
ALYS222
ATHR223
ALEU224
AHIS358
AMG502
BASP317
BARG343
BARG346

AC32binding site for residue MG A 502
ChainResidue
ATHR223
AATP501

AC414binding site for residue ATP B 501
ChainResidue
BILE187
BPRO228
BGLY229
BTHR230
BGLY231
BLYS232
BTHR233
BLEU234
BHIS368
BGLY392
BALA393
BLYS396
BMG502
CARG307

AC52binding site for residue MG B 502
ChainResidue
BTHR233
BATP501

AC611binding site for residue ADP C 501
ChainResidue
CMET150
CGLY152
CPRO192
CGLY193
CTHR194
CGLY195
CLYS196
CTHR197
CLEU198
CGLY356
CLYS360

AC715binding site for residue ATP D 501
ChainResidue
DILE167
DGLY168
DPRO208
DGLY209
DCYS210
DGLY211
DLYS212
DTHR213
DMET214
DGLY372
DALA373
DASN376
DMG502
EARG291
EARG294

AC82binding site for residue MG D 502
ChainResidue
DTHR213
DATP501

AC917binding site for residue ATP E 401
ChainResidue
EILE135
EGLY136
EPRO176
EGLY177
ETHR178
EGLY179
ELYS180
ETHR181
ELEU182
EASN280
EILE312
EHIS316
EGLY340
EALA341
EMG402
FARG344
FARG347

AD12binding site for residue MG E 402
ChainResidue
ETHR181
EATP401

AD214binding site for residue ADP F 501
ChainResidue
FILE188
FGLY189
FPRO229
FGLY230
FTHR231
FGLY232
FLYS233
FTHR234
FLEU235
FILE365
FHIS369
FGLY393
FLYS397
FMG502

AD33binding site for residue MG F 502
ChainResidue
FTHR234
FASP286
FADP501

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ATP_6msb_A_50124ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
AASP176-CYS180ATP: ADENOSINE-5'-TRIPHOSPHATE
APRO217-LEU224ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU276ATP: ADENOSINE-5'-TRIPHOSPHATE
AASN322ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE354ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE357-HIS358ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLY382-ALA383ATP: ADENOSINE-5'-TRIPHOSPHATE
AARG386ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP317ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG343ATP: ADENOSINE-5'-TRIPHOSPHATE
BARG346ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msb_F_50124ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
AARG333ADP: ADENOSINE-5'-DIPHOSPHATE
AARG336ADP: ADENOSINE-5'-DIPHOSPHATE
FASP187-GLY189ADP: ADENOSINE-5'-DIPHOSPHATE
FLEU191ADP: ADENOSINE-5'-DIPHOSPHATE
FPRO228-LEU235ADP: ADENOSINE-5'-DIPHOSPHATE
FARG238ADP: ADENOSINE-5'-DIPHOSPHATE
FASP286-GLU287ADP: ADENOSINE-5'-DIPHOSPHATE
FASN333ADP: ADENOSINE-5'-DIPHOSPHATE
FILE365ADP: ADENOSINE-5'-DIPHOSPHATE
FILE368-HIS369ADP: ADENOSINE-5'-DIPHOSPHATE
FGLY393-ALA394ADP: ADENOSINE-5'-DIPHOSPHATE
FLYS397ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msb_B_50122ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
BASP186-GLY188ATP: ADENOSINE-5'-TRIPHOSPHATE
BLEU190ATP: ADENOSINE-5'-TRIPHOSPHATE
BPRO227-LEU235ATP: ADENOSINE-5'-TRIPHOSPHATE
BASP285ATP: ADENOSINE-5'-TRIPHOSPHATE
BASN332ATP: ADENOSINE-5'-TRIPHOSPHATE
BILE364ATP: ADENOSINE-5'-TRIPHOSPHATE
BHIS368ATP: ADENOSINE-5'-TRIPHOSPHATE
BGLY392-ALA393ATP: ADENOSINE-5'-TRIPHOSPHATE
BLYS396ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG307ATP: ADENOSINE-5'-TRIPHOSPHATE
CARG310ATP: ADENOSINE-5'-TRIPHOSPHATE

ADP_6msb_C_50117ADENOSINE-5'-DIPHOSPHATE binding site
ChainResidueligand
CMET150-GLY152ADP: ADENOSINE-5'-DIPHOSPHATE
CLEU154ADP: ADENOSINE-5'-DIPHOSPHATE
CPRO191-LEU198ADP: ADENOSINE-5'-DIPHOSPHATE
CASP249ADP: ADENOSINE-5'-DIPHOSPHATE
CILE328ADP: ADENOSINE-5'-DIPHOSPHATE
CGLY356-ALA357ADP: ADENOSINE-5'-DIPHOSPHATE
CLYS360ADP: ADENOSINE-5'-DIPHOSPHATE

ATP_6msb_D_50123ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
DASP166-GLY168ATP: ADENOSINE-5'-TRIPHOSPHATE
DMET170ATP: ADENOSINE-5'-TRIPHOSPHATE
DPRO207-LEU215ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN312ATP: ADENOSINE-5'-TRIPHOSPHATE
DILE344ATP: ADENOSINE-5'-TRIPHOSPHATE
DILE348ATP: ADENOSINE-5'-TRIPHOSPHATE
DGLY372-ALA373ATP: ADENOSINE-5'-TRIPHOSPHATE
DASN376ATP: ADENOSINE-5'-TRIPHOSPHATE
EASP265ATP: ADENOSINE-5'-TRIPHOSPHATE
EALA288ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG291ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG294ATP: ADENOSINE-5'-TRIPHOSPHATE

ATP_6msb_E_40125ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
EGLU134-LEU138ATP: ADENOSINE-5'-TRIPHOSPHATE
EPRO175-LEU182ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLU234ATP: ADENOSINE-5'-TRIPHOSPHATE
EASN280ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE312ATP: ADENOSINE-5'-TRIPHOSPHATE
EILE315-HIS316ATP: ADENOSINE-5'-TRIPHOSPHATE
EGLY340-ALA341ATP: ADENOSINE-5'-TRIPHOSPHATE
EARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FASP318-GLY319ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG344ATP: ADENOSINE-5'-TRIPHOSPHATE
FARG347ATP: ADENOSINE-5'-TRIPHOSPHATE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails