6HB7

Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-N3-methyluridine

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation
A	0016020	cellular_component	membrane
A	0016874	molecular_function	ligase activity
A	0042803	molecular_function	protein homodimerization activity
A	0043039	biological_process	tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0003723	molecular_function	RNA binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004831	molecular_function	tyrosine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006437	biological_process	tyrosyl-tRNA aminoacylation
B	0016020	cellular_component	membrane
B	0016874	molecular_function	ligase activity
B	0042803	molecular_function	protein homodimerization activity
B	0043039	biological_process	tRNA aminoacylation

PDBデータベースに由来する情報

site_id	AC1
残基数	25
詳細	binding site for residue Y3U A 501

鎖名	残基
A	TYR37
A	TYR175
A	GLN179
A	ASP182
A	GLN195
A	GLY197
A	GLY198
A	ASP200
A	GLN201
A	VAL225
A	LEU227
A	GLY39
A	HOH603
A	HOH619
A	HOH654
A	HOH689
A	HOH715
A	HOH791
A	ASP41
A	GLY50
A	HIS51
A	PRO54
A	LEU71
A	THR76
A	ASP81

---

site_id	AC2
残基数	2
詳細	binding site for residue EDO A 502

鎖名	残基
A	ILE34
A	GLU118

---

site_id	AC3
残基数	7
詳細	binding site for residue EDO A 503

鎖名	残基
A	ARG105
A	ALA123
A	ALA124
A	ASN125
A	ASP128
A	HOH645
A	HOH729

---

site_id	AC4
残基数	7
詳細	binding site for residue EDO A 504

鎖名	残基
A	ILE386
A	GLU389
A	LYS390
A	GLN391
A	TYR396
A	GLU402
A	HOH614

---

site_id	AC5
残基数	4
詳細	binding site for residue CL A 505

鎖名	残基
A	PHE398
A	ARG403
A	HOH615
A	HOH695

---

site_id	AC6
残基数	24
詳細	binding site for residue Y3U B 501

鎖名	残基
B	TYR37
B	GLY39
B	ASP41
B	GLY50
B	HIS51
B	PRO54
B	LEU71
B	THR76
B	ASP81
B	TYR175
B	GLN179
B	ASP182
B	GLN195
B	GLY197
B	GLY198
B	ASP200
B	GLN201
B	VAL225
B	PRO226
B	LEU227
B	HOH604
B	HOH615
B	HOH646
B	HOH687

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00178
残基数	11
詳細	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.ADsLHLGHL

鎖名	残基	詳細
A	PRO42-LEU52

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	2
詳細	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000305|PubMed:15671170

鎖名	残基	詳細
A	TYR37
B	TYR37

---

site_id	SWS_FT_FI2
残基数	4
詳細	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998

鎖名	残基	詳細
A	TYR175
A	GLN179
B	TYR175
B	GLN179

---

site_id	SWS_FT_FI3
残基数	2
詳細	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006

鎖名	残基	詳細
A	LYS238
B	LYS238

---

site_id	SWS_FT_FI4
残基数	4
詳細	SITE: Cross-linked with tRNA by periodate oxidation

鎖名	残基	詳細
A	ALA231
A	LYS238
B	ALA231
B	LYS238

---

site_id	SWS_FT_FI5
残基数	2
詳細	SITE: Cross-linked with tRNA by periodate oxidation; predominant

鎖名	残基	詳細
A	LYS235
B	LYS235

---

site_id	SWS_FT_FI6
残基数	2
詳細	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

鎖名	残基	詳細
A	LYS144
B	LYS144

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