6FRF
Crystal structure of CREBBP bromodomain complexd with PA10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue E3T A 1201 |
| Chain | Residue |
| A | LEU1109 |
| A | HOH1322 |
| A | HOH1336 |
| D | E3T1201 |
| D | HOH1366 |
| A | PRO1110 |
| A | GLN1113 |
| A | VAL1115 |
| A | LEU1120 |
| A | ASN1168 |
| A | ARG1173 |
| A | VAL1174 |
| A | HOH1319 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue E3T B 1201 |
| Chain | Residue |
| B | LEU1109 |
| B | PRO1110 |
| B | GLN1113 |
| B | VAL1115 |
| B | LEU1120 |
| B | ASN1168 |
| B | ARG1173 |
| B | VAL1174 |
| B | PHE1177 |
| B | HOH1322 |
| C | ASP1116 |
| C | LEU1119 |
| C | E3T1201 |
| C | HOH1335 |
| D | TYR1175 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue E3T C 1201 |
| Chain | Residue |
| A | TYR1175 |
| B | LEU1119 |
| B | E3T1201 |
| B | HOH1341 |
| C | LEU1109 |
| C | PRO1110 |
| C | GLN1113 |
| C | VAL1115 |
| C | LEU1120 |
| C | ASN1168 |
| C | ARG1173 |
| C | PHE1177 |
| C | HOH1306 |
| C | HOH1308 |
| C | HOH1333 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue E3T D 1201 |
| Chain | Residue |
| A | LEU1120 |
| A | E3T1201 |
| D | PRO1110 |
| D | GLN1113 |
| D | VAL1115 |
| D | LEU1120 |
| D | ASN1168 |
| D | ARG1173 |
| D | VAL1174 |
| D | HOH1314 |
| D | HOH1338 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY |
| Chain | Residue | Details |
| A | SER1108-TYR1167 |
