5ZO1

Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain (Ig1-Ig3), 2.2A

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0031252cellular_componentcell leading edge
A0044291cellular_componentcell-cell contact zone
A0016021cellular_componentintegral component of membrane
A0019903molecular_functionprotein phosphatase binding
A0030971molecular_functionreceptor tyrosine kinase binding
A0043183molecular_functionvascular endothelial growth factor receptor 1 binding
A0043184molecular_functionvascular endothelial growth factor receptor 2 binding
A0007155biological_processcell adhesion
A0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
A0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
A0001933biological_processnegative regulation of protein phosphorylation
A0030948biological_processnegative regulation of vascular endothelial growth factor receptor signaling pathway
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A2000145biological_processregulation of cell motility
A0042127biological_processregulation of cell proliferation
A0001932biological_processregulation of protein phosphorylation
A0035020biological_processregulation of Rac protein signal transduction
A0061041biological_processregulation of wound healing
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15binding site for residue GOL A 404
ChainResidue
AARG260
ATHR290
AHIS299
AHOH513
AHOH592

AC210binding site for residue GOL A 405
ChainResidue
AGLU130
AVAL131
AARG132
AGLU142
ALEU143
ASER144
AGLN286
AVAL307
AHOH508
AHOH510

AC38binding site for Poly-Saccharide residues FUC A 401 through NAG A 403 bound to ASN A 67
ChainResidue
ATYR49
AGLY51
AILE53
AASN67
APHE82
ASER83
APRO84
AHOH565

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
NAG_5zo1_A_4035N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ATYR49NAG: N-ACETYL-D-GLUCOSAMINE
AGLY51NAG: N-ACETYL-D-GLUCOSAMINE
APHE82-PRO84NAG: N-ACETYL-D-GLUCOSAMINE

NAG_5zo1_A_4027N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ATYR49NAG: N-ACETYL-D-GLUCOSAMINE
AGLY51-ILE53NAG: N-ACETYL-D-GLUCOSAMINE
AASN67-GLY68NAG: N-ACETYL-D-GLUCOSAMINE
APHE82NAG: N-ACETYL-D-GLUCOSAMINE

FUC_5zo1_A_4014ALPHA-L-FUCOSE binding site
ChainResidueligand
AASN67-GLY68FUC: ALPHA-L-FUCOSE
ALEU79FUC: ALPHA-L-FUCOSE
APHE82FUC: ALPHA-L-FUCOSE

GOL_5zo1_A_4049GLYCEROL binding site
ChainResidueligand
AASN259-GLN262GOL: GLYCEROL
ATHR288-THR290GOL: GLYCEROL
AARG301GOL: GLYCEROL
ALEU303GOL: GLYCEROL

GOL_5zo1_A_4056GLYCEROL binding site
ChainResidueligand
ASER283GOL: GLYCEROL
AGLN286-GLY287GOL: GLYCEROL
ALEU306-VAL308GOL: GLYCEROL

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails