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5MWX

Galectin-1 in Complex with Ligand JB60

Functional Information from GO Data
ChainGOidnamespacecontents
A0002317biological_processplasma cell differentiation
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0016936molecular_functiongalactoside binding
A0030246molecular_functioncarbohydrate binding
A0030395molecular_functionlactose binding
A0031295biological_processT cell costimulation
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043236molecular_functionlaminin binding
A0045445biological_processmyoblast differentiation
A0046598biological_processpositive regulation of viral entry into host cell
A0050729biological_processpositive regulation of inflammatory response
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0098609biological_processcell-cell adhesion
A1990724cellular_componentgalectin complex
A2001200biological_processpositive regulation of dendritic cell differentiation
B0002317biological_processplasma cell differentiation
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0016936molecular_functiongalactoside binding
B0030246molecular_functioncarbohydrate binding
B0030395molecular_functionlactose binding
B0031295biological_processT cell costimulation
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043236molecular_functionlaminin binding
B0045445biological_processmyoblast differentiation
B0046598biological_processpositive regulation of viral entry into host cell
B0050729biological_processpositive regulation of inflammatory response
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0098609biological_processcell-cell adhesion
B1990724cellular_componentgalectin complex
B2001200biological_processpositive regulation of dendritic cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue BME A 201
ChainResidue
ALYS36
ALEU114
AGLU115
AALA116
AHOH341
AHOH382
BLYS28

site_idAC2
Number of Residues14
Detailsbinding site for residue WYD A 202
ChainResidue
AASN46
AARG48
AHIS52
AASN61
AGLU71
AARG73
AASP123
AGLY124
AASP125
AHOH302
AHOH349
BTHR70
ASER29
AHIS44

site_idAC3
Number of Residues9
Detailsbinding site for residue SO4 B 201
ChainResidue
APRO101
AASP102
BASN10
BLYS12
BHOH317
BHOH318
BHOH321
BHOH332
BHOH343

site_idAC4
Number of Residues15
Detailsbinding site for residue WYD B 202
ChainResidue
AGLN72
AGLN93
AASN113
BHIS44
BASN46
BARG48
BHIS52
BASN61
BGLU71
BARG73
BASP123
BGLY124
BHOH303
BHOH307
BHOH367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AHIS44
AHIS52
AASN61
ATRP68
BHIS44
BHIS52
BASN61
BTRP68

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P16045
ChainResidueDetails
ALYS12
ALYS127
BLYS12
BLYS127

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS28
BLYS28

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER29
BSER29

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P16045
ChainResidueDetails
ALYS107
BLYS107

218853

건을2024-04-24부터공개중

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