5J9Q

Crystal structure of the NuA4 core complex

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0000123	cellular_component	histone acetyltransferase complex
B	0004402	molecular_function	histone acetyltransferase activity
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006351	biological_process	DNA-templated transcription
B	0006974	biological_process	DNA damage response
B	0033100	cellular_component	NuA3 histone acetyltransferase complex
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	1990467	cellular_component	NuA3a histone acetyltransferase complex
B	1990468	cellular_component	NuA3b histone acetyltransferase complex
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0004402	molecular_function	histone acetyltransferase activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0000123	cellular_component	histone acetyltransferase complex
F	0004402	molecular_function	histone acetyltransferase activity
F	0005634	cellular_component	nucleus
F	0006281	biological_process	DNA repair
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006351	biological_process	DNA-templated transcription
F	0006974	biological_process	DNA damage response
F	0033100	cellular_component	NuA3 histone acetyltransferase complex
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	1990467	cellular_component	NuA3a histone acetyltransferase complex
F	1990468	cellular_component	NuA3b histone acetyltransferase complex
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0004402	molecular_function	histone acetyltransferase activity
I	0006355	biological_process	regulation of DNA-templated transcription
J	0000123	cellular_component	histone acetyltransferase complex
J	0004402	molecular_function	histone acetyltransferase activity
J	0005634	cellular_component	nucleus
J	0006281	biological_process	DNA repair
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006351	biological_process	DNA-templated transcription
J	0006974	biological_process	DNA damage response
J	0033100	cellular_component	NuA3 histone acetyltransferase complex
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	1990467	cellular_component	NuA3a histone acetyltransferase complex
J	1990468	cellular_component	NuA3b histone acetyltransferase complex
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0035267	cellular_component	NuA4 histone acetyltransferase complex

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	3
詳細	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16543222, ECO:0000269|PubMed:16543223

鎖名	残基	詳細
L	LYS4
M	LYS4
O	LYS4

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site_id	SWS_FT_FI2
残基数	3
詳細	ACT_SITE: Proton donor/acceptor => ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305

鎖名	残基	詳細
E	GLN338
A	GLN338
I	GLN338

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site_id	SWS_FT_FI3
残基数	9
詳細	BINDING: BINDING => ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126

鎖名	残基	詳細
E	ALA303
E	GLN312
E	SER342
A	ALA303
A	GLN312
A	SER342
I	ALA303
I	GLN312
I	SER342

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site_id	SWS_FT_FI4
残基数	3
詳細	SITE: Important for catalytic activity => ECO:0000305

鎖名	残基	詳細
E	CYS304
A	CYS304
I	CYS304

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site_id	SWS_FT_FI5
残基数	3
詳細	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22020126

鎖名	残基	詳細
E	ALY262
A	ALY262
I	ALY262

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CSAにおける酵素触媒機能の情報

site_id	MCSA1
残基数	2
詳細	M-CSA 525

鎖名	残基	詳細
E	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
E	GLN338	activator, proton acceptor, proton donor

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site_id	MCSA2
残基数	2
詳細	M-CSA 525

鎖名	残基	詳細
A	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLN338	activator, proton acceptor, proton donor

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site_id	MCSA3
残基数	2
詳細	M-CSA 525

鎖名	残基	詳細
I	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
I	GLN338	activator, proton acceptor, proton donor

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