5G06

Cryo-EM structure of yeast cytoplasmic exosome

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000176	cellular_component	nuclear exosome (RNase complex)
A	0000177	cellular_component	cytoplasmic exosome (RNase complex)
A	0000178	cellular_component	exosome (RNase complex)
A	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003674	molecular_function	molecular_function
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0006401	biological_process	RNA catabolic process
A	0016075	biological_process	rRNA catabolic process
A	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
A	0034473	biological_process	U1 snRNA 3'-end processing
A	0034475	biological_process	U4 snRNA 3'-end processing
A	0034476	biological_process	U5 snRNA 3'-end processing
A	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
A	0071028	biological_process	nuclear mRNA surveillance
A	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
A	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
A	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
B	0000176	cellular_component	nuclear exosome (RNase complex)
B	0000177	cellular_component	cytoplasmic exosome (RNase complex)
B	0000178	cellular_component	exosome (RNase complex)
B	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0003674	molecular_function	molecular_function
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0006364	biological_process	rRNA processing
B	0006396	biological_process	RNA processing
B	0006401	biological_process	RNA catabolic process
B	0016075	biological_process	rRNA catabolic process
B	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
B	0034473	biological_process	U1 snRNA 3'-end processing
B	0034475	biological_process	U4 snRNA 3'-end processing
B	0034476	biological_process	U5 snRNA 3'-end processing
B	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
B	0071028	biological_process	nuclear mRNA surveillance
B	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
B	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
B	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
C	0000176	cellular_component	nuclear exosome (RNase complex)
C	0000177	cellular_component	cytoplasmic exosome (RNase complex)
C	0000178	cellular_component	exosome (RNase complex)
C	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C	0003674	molecular_function	molecular_function
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0006397	biological_process	mRNA processing
C	0006401	biological_process	RNA catabolic process
C	0006402	biological_process	mRNA catabolic process
C	0016072	biological_process	rRNA metabolic process
C	0016075	biological_process	rRNA catabolic process
C	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
C	0034473	biological_process	U1 snRNA 3'-end processing
C	0034475	biological_process	U4 snRNA 3'-end processing
C	0034476	biological_process	U5 snRNA 3'-end processing
C	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
C	0071028	biological_process	nuclear mRNA surveillance
C	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
C	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
C	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
D	0000176	cellular_component	nuclear exosome (RNase complex)
D	0000177	cellular_component	cytoplasmic exosome (RNase complex)
D	0000178	cellular_component	exosome (RNase complex)
D	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D	0003674	molecular_function	molecular_function
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0006401	biological_process	RNA catabolic process
D	0016075	biological_process	rRNA catabolic process
D	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
D	0034475	biological_process	U4 snRNA 3'-end processing
D	0071028	biological_process	nuclear mRNA surveillance
D	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
D	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
D	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
D	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
E	0000176	cellular_component	nuclear exosome (RNase complex)
E	0000177	cellular_component	cytoplasmic exosome (RNase complex)
E	0000178	cellular_component	exosome (RNase complex)
E	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E	0003674	molecular_function	molecular_function
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006364	biological_process	rRNA processing
E	0006396	biological_process	RNA processing
E	0006401	biological_process	RNA catabolic process
E	0016075	biological_process	rRNA catabolic process
E	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
E	0034473	biological_process	U1 snRNA 3'-end processing
E	0034475	biological_process	U4 snRNA 3'-end processing
E	0034476	biological_process	U5 snRNA 3'-end processing
E	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
E	0071028	biological_process	nuclear mRNA surveillance
E	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
E	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
E	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
F	0000176	cellular_component	nuclear exosome (RNase complex)
F	0000177	cellular_component	cytoplasmic exosome (RNase complex)
F	0000178	cellular_component	exosome (RNase complex)
F	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F	0003674	molecular_function	molecular_function
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0006364	biological_process	rRNA processing
F	0006396	biological_process	RNA processing
F	0006401	biological_process	RNA catabolic process
F	0016075	biological_process	rRNA catabolic process
F	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
F	0034475	biological_process	U4 snRNA 3'-end processing
F	0071028	biological_process	nuclear mRNA surveillance
F	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
F	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
F	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
F	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
G	0000176	cellular_component	nuclear exosome (RNase complex)
G	0000177	cellular_component	cytoplasmic exosome (RNase complex)
G	0000178	cellular_component	exosome (RNase complex)
G	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0006401	biological_process	RNA catabolic process
G	0030145	molecular_function	manganese ion binding
G	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
G	0034475	biological_process	U4 snRNA 3'-end processing
G	0043229	cellular_component	intracellular organelle
G	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
G	0071034	biological_process	CUT catabolic process
G	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
G	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
G	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
H	0000176	cellular_component	nuclear exosome (RNase complex)
H	0000177	cellular_component	cytoplasmic exosome (RNase complex)
H	0000178	cellular_component	exosome (RNase complex)
H	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H	0003674	molecular_function	molecular_function
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0006364	biological_process	rRNA processing
H	0006396	biological_process	RNA processing
H	0006401	biological_process	RNA catabolic process
H	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
H	0034475	biological_process	U4 snRNA 3'-end processing
H	0043928	biological_process	obsolete exonucleolytic catabolism of deadenylated mRNA
H	0071028	biological_process	nuclear mRNA surveillance
H	0071034	biological_process	CUT catabolic process
H	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
H	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
H	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
I	0000176	cellular_component	nuclear exosome (RNase complex)
I	0000177	cellular_component	cytoplasmic exosome (RNase complex)
I	0000178	cellular_component	exosome (RNase complex)
I	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0003674	molecular_function	molecular_function
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0006364	biological_process	rRNA processing
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0006401	biological_process	RNA catabolic process
I	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
I	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
I	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
I	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
J	0000049	molecular_function	tRNA binding
J	0000175	molecular_function	3'-5'-RNA exonuclease activity
J	0000176	cellular_component	nuclear exosome (RNase complex)
J	0000177	cellular_component	cytoplasmic exosome (RNase complex)
J	0000178	cellular_component	exosome (RNase complex)
J	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0004518	molecular_function	nuclease activity
J	0004519	molecular_function	endonuclease activity
J	0004521	molecular_function	RNA endonuclease activity
J	0004527	molecular_function	exonuclease activity
J	0004540	molecular_function	RNA nuclease activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0006364	biological_process	rRNA processing
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0006401	biological_process	RNA catabolic process
J	0016075	biological_process	rRNA catabolic process
J	0016787	molecular_function	hydrolase activity
J	0043628	biological_process	regulatory ncRNA 3'-end processing
J	0070651	biological_process	nonfunctional rRNA decay
J	0071028	biological_process	nuclear mRNA surveillance
J	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
J	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
J	0071039	biological_process	nuclear polyadenylation-dependent CUT catabolic process
P	0000166	molecular_function	nucleotide binding
P	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
P	0003746	molecular_function	translation elongation factor activity
P	0003924	molecular_function	GTPase activity
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006412	biological_process	translation
P	0006414	biological_process	translational elongation
P	0006417	biological_process	regulation of translation
P	0006790	biological_process	sulfur compound metabolic process
P	0030163	biological_process	protein catabolic process
P	0030674	molecular_function	protein-macromolecule adaptor activity
P	0034427	biological_process	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
P	0044877	molecular_function	protein-containing complex binding
P	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
P	0070481	biological_process	nuclear-transcribed mRNA catabolic process, non-stop decay
P	0070651	biological_process	nonfunctional rRNA decay

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS01175
残基数	25
詳細	RIBONUCLEASE_II Ribonuclease II family signature. HYGLavdi.YThFTSPIRRYcDvvaH

鎖名	残基	詳細
J	HIS831-HIS855

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	3
詳細	BINDING: BINDING => ECO:0000250

鎖名	残基	詳細
P	GLY129
P	ASP211
P	ASN282

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site_id	SWS_FT_FI2
残基数	2
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358

鎖名	残基	詳細
P	SER-57
P	SER-55

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site_id	SWS_FT_FI3
残基数	1
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

鎖名	残基	詳細
H	SER268

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