Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006259 | biological_process | DNA metabolic process |
A | 0006265 | biological_process | DNA topological change |
B | 0003677 | molecular_function | DNA binding |
B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006259 | biological_process | DNA metabolic process |
B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1301 |
Chain | Residue |
A | ASP557 |
A | ASP559 |
A | HOH1401 |
A | HOH1614 |
A | HOH1615 |
C | HOH103 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 1302 |
Chain | Residue |
C | HOH122 |
C | HOH123 |
A | ASN867 |
A | GLY868 |
A | HOH1624 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 1303 |
Chain | Residue |
A | PHE722 |
A | ASP726 |
A | HOH1430 |
F | DC16 |
F | HOH213 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1301 |
Chain | Residue |
B | ASP557 |
B | ASP559 |
B | HOH1402 |
B | HOH1434 |
B | HOH1516 |
B | HOH1672 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1302 |
Chain | Residue |
B | ASN795 |
B | ASN867 |
B | HOH1679 |
B | HOH1680 |
E | HOH124 |
E | HOH125 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 101 |
Chain | Residue |
B | HOH1612 |
B | HOH1740 |
D | HOH202 |
D | HOH203 |
D | HOH208 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG F 101 |
Chain | Residue |
A | HOH1626 |
A | HOH1627 |
F | HOH214 |
F | HOH215 |
F | HOH216 |
Functional Information from PROSITE/UniProt
site_id | PS00177 |
Number of Residues | 9 |
Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS |
Chain | Residue | Details |
A | LEU475-SER483 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | TYR821 | |
B | TYR821 | |
Chain | Residue | Details |
A | GLU477 | |
B | GLU477 | |
Chain | Residue | Details |
A | ASP557 | |
A | ASP559 | |
B | ASP557 | |
B | ASP559 | |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | LYS505 | |
B | LYS678 | |
B | LYS739 | |
B | TRP947 | |
A | ASN508 | |
A | ARG677 | |
A | LYS678 | |
A | LYS739 | |
A | TRP947 | |
B | LYS505 | |
B | ASN508 | |
B | ARG677 | |
Chain | Residue | Details |
A | TYR773 | |
B | TYR773 | |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | ARG820 | |
B | ARG820 | |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Important for DNA bending; intercalates between base pairs of target DNA |
Chain | Residue | Details |
A | ILE872 | |
B | ILE872 | |
site_id | SWS_FT_FI8 |
Number of Residues | 14 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS595 | |
B | LYS630 | |
B | LYS641 | |
B | LYS671 | |
B | LYS707 | |
B | LYS1087 | |
A | LYS630 | |
A | LYS641 | |
A | LYS671 | |
A | LYS707 | |
A | LYS1087 | |
B | LYS595 | |
Chain | Residue | Details |
A | LYS600 | |
A | LYS638 | |
B | LYS600 | |
B | LYS638 | |