4CRN
Cryo-EM of a pretermination complex with eRF1 and eRF3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| P | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| P | 0003747 | molecular_function | translation release factor activity |
| P | 0003924 | molecular_function | GTPase activity |
| P | 0005525 | molecular_function | GTP binding |
| P | 0006415 | biological_process | translational termination |
| X | 0002184 | biological_process | cytoplasmic translational termination |
| X | 0003747 | molecular_function | translation release factor activity |
| X | 0004045 | molecular_function | aminoacyl-tRNA hydrolase activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005829 | cellular_component | cytosol |
| X | 0006353 | biological_process | DNA-templated transcription termination |
| X | 0006412 | biological_process | translation |
| X | 0006415 | biological_process | translational termination |
| X | 0009302 | biological_process | sno(s)RNA transcription |
| X | 0010467 | biological_process | gene expression |
| X | 0010494 | cellular_component | cytoplasmic stress granule |
| X | 0016070 | biological_process | RNA metabolic process |
| X | 0016149 | molecular_function | translation release factor activity, codon specific |
| X | 0018444 | cellular_component | translation release factor complex |
| X | 1990825 | molecular_function | sequence-specific mRNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GNP P 1685 |
| Chain | Residue |
| P | HIS267 |
| P | TYR307 |
| P | LYS323 |
| P | THR324 |
| P | ILE325 |
| P | ASP343 |
| P | ALA344 |
| P | PRO345 |
| P | GLY346 |
| P | LYS348 |
| P | ASN405 |
| P | VAL268 |
| P | LYS406 |
| P | ASP409 |
| P | GLY448 |
| P | ASP269 |
| P | ALA270 |
| P | GLY271 |
| P | LYS272 |
| P | SER273 |
| P | GLN304 |
| P | GLY305 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DTnkeERnDGKTIevG |
| Chain | Residue | Details |
| P | ASP313-GLY328 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N5-methylglutamine => ECO:0000269|PubMed:15509572, ECO:0000269|PubMed:16321977 |
| Chain | Residue | Details |
| X | GLN182 | |
| P | ASN405 | |
| P | GLY448 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| X | SER421 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| X | LYS331 |
