3OKU

Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0002009	biological_process	morphogenesis of an epithelium
A	0004064	molecular_function	arylesterase activity
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0015670	biological_process	carbon dioxide transport
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0018820	molecular_function	cyanamide hydratase activity
A	0032230	biological_process	positive regulation of synaptic transmission, GABAergic
A	0032849	biological_process	positive regulation of cellular pH reduction
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0043209	cellular_component	myelin sheath
A	0044070	biological_process	regulation of monoatomic anion transport
A	0045177	cellular_component	apical part of cell
A	0046872	molecular_function	metal ion binding
A	0046903	biological_process	secretion
A	0051453	biological_process	regulation of intracellular pH
A	0070050	biological_process	neuron cellular homeostasis
A	0070062	cellular_component	extracellular exosome
A	2001150	biological_process	positive regulation of dipeptide transmembrane transport
A	2001225	biological_process	regulation of chloride transport

PDBデータベースに由来する情報

site_id	AC1
残基数	5
詳細	BINDING SITE FOR RESIDUE ZN A 262

鎖名	残基
A	HIS94
A	HIS96
A	HIS119
A	VZ4263
A	HOH570

---

site_id	AC2
残基数	23
詳細	BINDING SITE FOR RESIDUE VZ4 A 263

鎖名	残基
A	VAL121
A	PHE131
A	LEU141
A	LEU198
A	THR199
A	THR200
A	PRO201
A	PRO202
A	ZN262
A	GOL265
A	HOH458
A	HOH470
A	HOH488
A	HOH570
A	HOH571
A	HOH572
A	HOH573
A	HOH574
A	HOH578
A	GLN92
A	HIS94
A	HIS96
A	HIS119

---

site_id	AC3
残基数	7
詳細	BINDING SITE FOR RESIDUE DMS A 264

鎖名	残基
A	TYR7
A	ASP243
A	TRP245
A	HOH545
A	HOH550
A	HOH580
A	HOH598

---

site_id	AC4
残基数	14
詳細	BINDING SITE FOR RESIDUE GOL A 265

鎖名	残基
A	ASN62
A	HIS64
A	ALA65
A	ASN67
A	GLN92
A	HIS94
A	VZ4263
A	HOH280
A	HOH285
A	HOH326
A	HOH329
A	HOH528
A	HOH572
A	HOH578

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00162
残基数	17
詳細	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV

鎖名	残基	詳細
A	SER105-VAL121

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962

鎖名	残基	詳細
A	HIS64

---

site_id	SWS_FT_FI2
残基数	1
詳細	BINDING: BINDING => ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:4621826, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942

鎖名	残基	詳細
A	HIS94

---

site_id	SWS_FT_FI3
残基数	2
詳細	BINDING: BINDING => ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942

鎖名	残基	詳細
A	HIS96
A	HIS119

---

site_id	SWS_FT_FI4
残基数	1
詳細	BINDING: BINDING => ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:19520834

鎖名	残基	詳細
A	THR199

---

site_id	SWS_FT_FI5
残基数	1
詳細	SITE: Fine-tunes the proton-transfer properties of H-64 => ECO:0000305|PubMed:17330962

鎖名	残基	詳細
A	TYR7

---

site_id	SWS_FT_FI6
残基数	2
詳細	SITE: Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962

鎖名	残基	詳細
A	ASN62
A	ASN67

---

site_id	SWS_FT_FI7
残基数	1
詳細	SITE: Involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962

鎖名	残基	詳細
A	GLN92

---

site_id	SWS_FT_FI8
残基数	1
詳細	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27139

鎖名	残基	詳細
A	SER2

---

site_id	SWS_FT_FI9
残基数	2
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

鎖名	残基	詳細
A	SER166
A	SER173

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CSAにおける酵素触媒機能の情報

site_id	MCSA1
残基数	6
詳細	M-CSA 216

鎖名	残基	詳細
A	HIS64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS94	metal ligand
A	HIS96	metal ligand
A	GLU106	activator, electrostatic stabiliser, hydrogen bond acceptor
A	HIS119	metal ligand
A	THR199	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity

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