2Y8Q

Structure of the regulatory fragment of mammalian AMPK in complex with one ADP

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004679	molecular_function	AMP-activated protein kinase activity
E	0004672	molecular_function	protein kinase activity
E	0004679	molecular_function	AMP-activated protein kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006633	biological_process	fatty acid biosynthetic process
E	0010628	biological_process	positive regulation of gene expression
E	0016208	molecular_function	AMP binding
E	0019887	molecular_function	protein kinase regulator activity
E	0019901	molecular_function	protein kinase binding
E	0031588	cellular_component	nucleotide-activated protein kinase complex
E	0031669	biological_process	cellular response to nutrient levels
E	0032991	cellular_component	protein-containing complex
E	0043531	molecular_function	ADP binding
E	0044877	molecular_function	protein-containing complex binding
E	0051170	biological_process	import into nucleus

PDBデータベースに由来する情報

site_id	AC1
残基数	11
詳細	BINDING SITE FOR RESIDUE ADP E 1327

鎖名	残基
E	MET84
E	ARG151
E	PRO153
E	THR86
E	THR88
E	ASP89
E	PRO127
E	LEU128
E	VAL129
E	ILE149
E	HIS150

---

site_id	AC2
残基数	14
詳細	BINDING SITE FOR RESIDUE AMP E 1328

鎖名	残基
A	ARG457
E	HIS150
E	THR199
E	ILE203
E	ALA204
E	VAL224
E	SER225
E	ALA226
E	PRO228
E	ILE311
E	SER313
E	SER315
E	ASP316
E	HOH2039

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	8
詳細	BINDING: BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92

鎖名	残基	詳細
E	ARG69
E	MET84
E	VAL129
E	ARG151
E	LYS169
E	SER241
E	ARG268
E	LEU276

---

site_id	SWS_FT_FI2
残基数	6
詳細	BINDING: BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L

鎖名	残基	詳細
E	HIS150
E	THR199
E	ALA204
E	SER225
E	HIS297
E	SER313

---

site_id	SWS_FT_FI3
残基数	1
詳細	MOD_RES: Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634

鎖名	残基	詳細
E	SER260

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site_id	SWS_FT_FI4
残基数	1
詳細	MOD_RES: Phosphothreonine; by ULK1 => ECO:0000305|PubMed:21460634

鎖名	残基	詳細
E	THR262

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site_id	SWS_FT_FI5
残基数	1
詳細	MOD_RES: Phosphoserine; by ULK1 => ECO:0000269|PubMed:21460634

鎖名	残基	詳細
E	SER269

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