Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XWJ

Crystal Structure of Complement C3b in Complex with Factor B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
C	0004866	molecular_function	endopeptidase inhibitor activity
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
E	0004866	molecular_function	endopeptidase inhibitor activity
F	0004866	molecular_function	endopeptidase inhibitor activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
G	0004866	molecular_function	endopeptidase inhibitor activity
H	0004866	molecular_function	endopeptidase inhibitor activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
I	0001848	molecular_function	complement binding
I	0002376	biological_process	immune system process
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005601	cellular_component	classical-complement-pathway C3/C5 convertase complex
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0006956	biological_process	complement activation
I	0006957	biological_process	complement activation, alternative pathway
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009617	biological_process	response to bacterium
I	0016787	molecular_function	hydrolase activity
I	0045087	biological_process	innate immune response
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
J	0001848	molecular_function	complement binding
J	0002376	biological_process	immune system process
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005601	cellular_component	classical-complement-pathway C3/C5 convertase complex
J	0005615	cellular_component	extracellular space
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0006956	biological_process	complement activation
J	0006957	biological_process	complement activation, alternative pathway
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009617	biological_process	response to bacterium
J	0016787	molecular_function	hydrolase activity
J	0045087	biological_process	innate immune response
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
K	0001848	molecular_function	complement binding
K	0002376	biological_process	immune system process
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005601	cellular_component	classical-complement-pathway C3/C5 convertase complex
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0006508	biological_process	proteolysis
K	0006956	biological_process	complement activation
K	0006957	biological_process	complement activation, alternative pathway
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009617	biological_process	response to bacterium
K	0016787	molecular_function	hydrolase activity
K	0045087	biological_process	innate immune response
K	0070062	cellular_component	extracellular exosome
K	0072562	cellular_component	blood microparticle
L	0001848	molecular_function	complement binding
L	0002376	biological_process	immune system process
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005601	cellular_component	classical-complement-pathway C3/C5 convertase complex
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0006956	biological_process	complement activation
L	0006957	biological_process	complement activation, alternative pathway
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009617	biological_process	response to bacterium
L	0016787	molecular_function	hydrolase activity
L	0045087	biological_process	innate immune response
L	0070062	cellular_component	extracellular exosome
L	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM

Chain	Residue	Details
B	PRO985-MET993

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
I	LEU497-CYS502

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI

Chain	Residue	Details
I	ASN668-ILE679

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
I	HIS501
L	HIS501
L	ASP551
L	SER674
I	ASP551
I	SER674
J	HIS501
J	ASP551
J	SER674
K	HIS501
K	ASP551
K	SER674

site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:17310251, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:6546754

Chain	Residue	Details
I	ASN97
E	SER48
E	SER275
E	SER281
G	SER16
G	SER48
G	SER275
G	SER281
I	ASP260
J	ASN97
J	ASP260
K	ASN97
K	ASP260
L	ASN97
L	ASP260
E	SER16

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:17310251, ECO:0000269\|PubMed:19574954, ECO:0000269\|PubMed:6546754

Chain	Residue	Details
I	ASN117
J	ASN117
K	ASN117
L	ASN117

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:2006911

Chain	Residue	Details
I	LYS266
H	SER946
H	SER1299
H	SER1551
J	LYS266
K	LYS266
L	LYS266
D	SER1299
D	SER1551
F	SER946
F	SER1299
F	SER1551

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:17310251, ECO:0000269\|PubMed:19574954, ECO:0000269\|PubMed:6546754

Chain	Residue	Details
I	ASN353
J	ASN353
K	ASN353
L	ASN353

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952

Chain	Residue	Details
B	ASN1595
D	ASN1595
F	ASN1595
H	ASN1595

site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS988
B	GLU991
D	CYS988
D	GLU991
F	CYS988
F	GLU991
H	CYS988
H	GLU991

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)