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2AIR

T-state Active Site of Aspartate Transcarbamylase:Crystal Structure of the Carbamyl Phosphate and L-alanosine Ligated Enzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0004070molecular_functionaspartate carbamoyltransferase activity
A0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006520biological_processamino acid metabolic process
A0006541biological_processglutamine metabolic process
A0009347cellular_componentaspartate carbamoyltransferase complex
A0016597molecular_functionamino acid binding
A0016740molecular_functiontransferase activity
A0016743molecular_functioncarboxyl- or carbamoyltransferase activity
A0042802molecular_functionidentical protein binding
A0044205biological_process'de novo' UMP biosynthetic process
A0070207biological_processprotein homotrimerization
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0008270molecular_functionzinc ion binding
B0009347cellular_componentaspartate carbamoyltransferase complex
B0046872molecular_functionmetal ion binding
G0004070molecular_functionaspartate carbamoyltransferase activity
G0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
G0006221biological_processpyrimidine nucleotide biosynthetic process
G0006520biological_processamino acid metabolic process
G0006541biological_processglutamine metabolic process
G0009347cellular_componentaspartate carbamoyltransferase complex
G0016597molecular_functionamino acid binding
G0016740molecular_functiontransferase activity
G0016743molecular_functioncarboxyl- or carbamoyltransferase activity
G0042802molecular_functionidentical protein binding
G0044205biological_process'de novo' UMP biosynthetic process
G0070207biological_processprotein homotrimerization
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
H0006221biological_processpyrimidine nucleotide biosynthetic process
H0008270molecular_functionzinc ion binding
H0009347cellular_componentaspartate carbamoyltransferase complex
H0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 800
ChainResidue
BCYS109
BCYS114
BCYS138
BCYS141

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN H 801
ChainResidue
HCYS109
HCYS114
HCYS138
HCYS141

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CP A 802
ChainResidue
ATHR55
AARG105
AHIS134
AAL0805
AARG54

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CP G 803
ChainResidue
GARG54
GTHR55
GARG105
GHIS134
GARG229
GAL0804

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE AL0 G 804
ChainResidue
GALA51
GSER52
GARG54
GTHR55
GSER80
GARG105
GCP803

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE AL0 A 805
ChainResidue
AALA51
ASER52
ATHR53
AARG54
ASER80
AARG105
ACP802

Functional Information from PROSITE/UniProt
site_idPS00097
Number of Residues8
DetailsCARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT
ChainResidueDetails
APHE48-THR55

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
BPRO110
GHIS106
GPRO135
GTHR138
GPRO268
GARG269
BILE115
BLYS139
BGLU142
HPRO110
HILE115
HLYS139
HGLU142
GARG56

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787
ChainResidueDetails
AGLY85
ATHR168
AVAL230
GGLY85
GTHR168
GVAL230

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 405
ChainResidueDetails
ATHR55electrostatic stabiliser
AARG56electrostatic stabiliser, increase electrophilicity
AGLY85proton shuttle (general acid/base)
AHIS106electrostatic stabiliser, increase electrophilicity
APRO135electrostatic stabiliser, increase electrophilicity

site_idMCSA2
Number of Residues5
DetailsM-CSA 405
ChainResidueDetails
GTHR55electrostatic stabiliser
GARG56electrostatic stabiliser, increase electrophilicity
GGLY85proton shuttle (general acid/base)
GHIS106electrostatic stabiliser, increase electrophilicity
GPRO135electrostatic stabiliser, increase electrophilicity

217705

數據於2024-03-27公開中

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