2AIR

T-state Active Site of Aspartate Transcarbamylase:Crystal Structure of the Carbamyl Phosphate and L-alanosine Ligated Enzyme

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0006541	biological_process	glutamine metabolic process
A	0009347	cellular_component	aspartate carbamoyltransferase complex
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0070207	biological_process	protein homotrimerization
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0009347	cellular_component	aspartate carbamoyltransferase complex
B	0046872	molecular_function	metal ion binding
G	0004070	molecular_function	aspartate carbamoyltransferase activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006520	biological_process	amino acid metabolic process
G	0006541	biological_process	glutamine metabolic process
G	0009347	cellular_component	aspartate carbamoyltransferase complex
G	0016597	molecular_function	amino acid binding
G	0016740	molecular_function	transferase activity
G	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
G	0042802	molecular_function	identical protein binding
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0070207	biological_process	protein homotrimerization
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0008270	molecular_function	zinc ion binding
H	0009347	cellular_component	aspartate carbamoyltransferase complex
H	0046872	molecular_function	metal ion binding

PDBデータベースに由来する情報

site_id	AC1
残基数	4
詳細	BINDING SITE FOR RESIDUE ZN B 800

鎖名	残基
B	CYS109
B	CYS114
B	CYS138
B	CYS141

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site_id	AC2
残基数	4
詳細	BINDING SITE FOR RESIDUE ZN H 801

鎖名	残基
H	CYS109
H	CYS114
H	CYS138
H	CYS141

---

site_id	AC3
残基数	5
詳細	BINDING SITE FOR RESIDUE CP A 802

鎖名	残基
A	THR55
A	ARG105
A	HIS134
A	AL0805
A	ARG54

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site_id	AC4
残基数	6
詳細	BINDING SITE FOR RESIDUE CP G 803

鎖名	残基
G	ARG54
G	THR55
G	ARG105
G	HIS134
G	ARG229
G	AL0804

---

site_id	AC5
残基数	7
詳細	BINDING SITE FOR RESIDUE AL0 G 804

鎖名	残基
G	ALA51
G	SER52
G	ARG54
G	THR55
G	SER80
G	ARG105
G	CP803

---

site_id	AC6
残基数	7
詳細	BINDING SITE FOR RESIDUE AL0 A 805

鎖名	残基
A	ALA51
A	SER52
A	THR53
A	ARG54
A	SER80
A	ARG105
A	CP802

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00097
残基数	8
詳細	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT

鎖名	残基	詳細
A	PHE48-THR55

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	8
詳細	BINDING:

鎖名	残基	詳細
B	PRO110
G	HIS106
G	PRO135
G	THR138
G	PRO268
G	ARG269
B	ILE115
B	LYS139
B	GLU142
H	PRO110
H	ILE115
H	LYS139
H	GLU142
G	ARG56

---

site_id	SWS_FT_FI2
残基数	6
詳細	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787

鎖名	残基	詳細
A	GLY85
A	THR168
A	VAL230
G	GLY85
G	THR168
G	VAL230

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CSAにおける酵素触媒機能の情報

site_id	MCSA1
残基数	5
詳細	M-CSA 405

鎖名	残基	詳細
A	THR55	electrostatic stabiliser
A	ARG56	electrostatic stabiliser, increase electrophilicity
A	GLY85	proton shuttle (general acid/base)
A	HIS106	electrostatic stabiliser, increase electrophilicity
A	PRO135	electrostatic stabiliser, increase electrophilicity

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site_id	MCSA2
残基数	5
詳細	M-CSA 405

鎖名	残基	詳細
G	THR55	electrostatic stabiliser
G	ARG56	electrostatic stabiliser, increase electrophilicity
G	GLY85	proton shuttle (general acid/base)
G	HIS106	electrostatic stabiliser, increase electrophilicity
G	PRO135	electrostatic stabiliser, increase electrophilicity

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