1QOL

STRUCTURE OF THE FMDV LEADER PROTEASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0016032	biological_process	viral process
A	0019082	biological_process	viral protein processing
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0016032	biological_process	viral process
B	0019082	biological_process	viral protein processing
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0016032	biological_process	viral process
C	0019082	biological_process	viral protein processing
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0016032	biological_process	viral process
D	0019082	biological_process	viral protein processing
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0016032	biological_process	viral process
E	0019082	biological_process	viral protein processing
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0016032	biological_process	viral process
F	0019082	biological_process	viral protein processing
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0016032	biological_process	viral process
G	0019082	biological_process	viral protein processing
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0016032	biological_process	viral process
H	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL Z 1

Chain	Residue
A	ALA135
D	LEU134
D	ALA135

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL Z 2

Chain	Residue
B	ALA135
C	ALA135

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL Z 3

Chain	Residue
G	ALA135
E	CYS133
E	ALA135
G	CYS133
G	LEU134

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	GLU76
A	ASN77
A	GLU81
F	GLU76

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 301

Chain	Residue
B	ASN77
B	GLU81
E	GLU76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763, ECO:0000269|PubMed:9857201

Chain	Residue	Details
A	ALA51
E	HIS148
F	ALA51
F	HIS148
G	ALA51
G	HIS148
H	ALA51
H	HIS148
A	HIS148
B	ALA51
B	HIS148
C	ALA51
C	HIS148
D	ALA51
D	HIS148
E	ALA51

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763

Chain	Residue	Details
A	ASP163
B	ASP163
C	ASP163
D	ASP163
E	ASP163
F	ASP163
G	ASP163
H	ASP163

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Cleavage; by leader protease => ECO:0000255

Chain	Residue	Details
A	LYS201
B	LYS201
C	LYS201
D	LYS201
E	LYS201
F	LYS201
G	LYS201
H	LYS201

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details

Chain	Residue	Details
A	ALA51
A	HIS148
A	ASP163

---

site_id	CSA2
Number of Residues	3
Details

Chain	Residue	Details
B	ALA51
B	HIS148
B	ASP163

---

site_id	CSA3
Number of Residues	3
Details

Chain	Residue	Details
C	ALA51
C	HIS148
C	ASP163

---

site_id	CSA4
Number of Residues	3
Details

Chain	Residue	Details
D	ALA51
D	HIS148
D	ASP163

---

site_id	CSA5
Number of Residues	3
Details

Chain	Residue	Details
E	ALA51
E	HIS148
E	ASP163

---

site_id	CSA6
Number of Residues	3
Details

Chain	Residue	Details
F	ALA51
F	HIS148
F	ASP163

---

site_id	CSA7
Number of Residues	3
Details

Chain	Residue	Details
G	ALA51
G	HIS148
G	ASP163

---

site_id	CSA8
Number of Residues	3
Details

Chain	Residue	Details
H	ALA51
H	HIS148
H	ASP163

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
A	ASN46	electrostatic stabiliser, polar interaction
A	ALA51	electrostatic stabiliser, polar interaction
A	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
A	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
B	ASN46	electrostatic stabiliser, polar interaction
B	ALA51	electrostatic stabiliser, polar interaction
B	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
B	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
C	ASN46	electrostatic stabiliser, polar interaction
C	ALA51	electrostatic stabiliser, polar interaction
C	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
C	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
D	ASN46	electrostatic stabiliser, polar interaction
D	ALA51	electrostatic stabiliser, polar interaction
D	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
D	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA5
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
E	ASN46	electrostatic stabiliser, polar interaction
E	ALA51	electrostatic stabiliser, polar interaction
E	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
E	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA6
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
F	ASN46	electrostatic stabiliser, polar interaction
F	ALA51	electrostatic stabiliser, polar interaction
F	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
F	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA7
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
G	ASN46	electrostatic stabiliser, polar interaction
G	ALA51	electrostatic stabiliser, polar interaction
G	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
G	ASP163	electrostatic stabiliser, hydrogen bond donor

---

site_id	MCSA8
Number of Residues	4
Details	M-CSA 746

Chain	Residue	Details
H	ASN46	electrostatic stabiliser, polar interaction
H	ALA51	electrostatic stabiliser, polar interaction
H	HIS148	hydrogen bond acceptor, proton acceptor, proton donor
H	ASP163	electrostatic stabiliser, hydrogen bond donor

---