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1QOL

STRUCTURE OF THE FMDV LEADER PROTEASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0016032biological_processviral process
A0019082biological_processviral protein processing
B0004197molecular_functioncysteine-type endopeptidase activity
B0016032biological_processviral process
B0019082biological_processviral protein processing
C0004197molecular_functioncysteine-type endopeptidase activity
C0016032biological_processviral process
C0019082biological_processviral protein processing
D0004197molecular_functioncysteine-type endopeptidase activity
D0016032biological_processviral process
D0019082biological_processviral protein processing
E0004197molecular_functioncysteine-type endopeptidase activity
E0016032biological_processviral process
E0019082biological_processviral protein processing
F0004197molecular_functioncysteine-type endopeptidase activity
F0016032biological_processviral process
F0019082biological_processviral protein processing
G0004197molecular_functioncysteine-type endopeptidase activity
G0016032biological_processviral process
G0019082biological_processviral protein processing
H0004197molecular_functioncysteine-type endopeptidase activity
H0016032biological_processviral process
H0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL Z 1
ChainResidue
AALA135
DLEU134
DALA135

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL Z 2
ChainResidue
BALA135
CALA135

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL Z 3
ChainResidue
GALA135
ECYS133
EALA135
GCYS133
GLEU134

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 301
ChainResidue
AGLU76
AASN77
AGLU81
FGLU76

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B 301
ChainResidue
BASN77
BGLU81
EGLU76

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763, ECO:0000269|PubMed:9857201
ChainResidueDetails
AALA51
EHIS148
FALA51
FHIS148
GALA51
GHIS148
HALA51
HHIS148
AHIS148
BALA51
BHIS148
CALA51
CHIS148
DALA51
DHIS148
EALA51

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: For leader protease activity => ECO:0000269|PubMed:29463763
ChainResidueDetails
AASP163
BASP163
CASP163
DASP163
EASP163
FASP163
GASP163
HASP163

site_idSWS_FT_FI3
Number of Residues8
DetailsSITE: Cleavage; by leader protease => ECO:0000255
ChainResidueDetails
ALYS201
BLYS201
CLYS201
DLYS201
ELYS201
FLYS201
GLYS201
HLYS201

Catalytic Information from CSA
site_idCSA1
Number of Residues3
Details
ChainResidueDetails
AALA51
AHIS148
AASP163

site_idCSA2
Number of Residues3
Details
ChainResidueDetails
BALA51
BHIS148
BASP163

site_idCSA3
Number of Residues3
Details
ChainResidueDetails
CALA51
CHIS148
CASP163

site_idCSA4
Number of Residues3
Details
ChainResidueDetails
DALA51
DHIS148
DASP163

site_idCSA5
Number of Residues3
Details
ChainResidueDetails
EALA51
EHIS148
EASP163

site_idCSA6
Number of Residues3
Details
ChainResidueDetails
FALA51
FHIS148
FASP163

site_idCSA7
Number of Residues3
Details
ChainResidueDetails
GALA51
GHIS148
GASP163

site_idCSA8
Number of Residues3
Details
ChainResidueDetails
HALA51
HHIS148
HASP163

site_idMCSA1
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
AASN46electrostatic stabiliser, polar interaction
AALA51electrostatic stabiliser, polar interaction
AHIS148hydrogen bond acceptor, proton acceptor, proton donor
AASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA2
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
BASN46electrostatic stabiliser, polar interaction
BALA51electrostatic stabiliser, polar interaction
BHIS148hydrogen bond acceptor, proton acceptor, proton donor
BASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA3
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
CASN46electrostatic stabiliser, polar interaction
CALA51electrostatic stabiliser, polar interaction
CHIS148hydrogen bond acceptor, proton acceptor, proton donor
CASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA4
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
DASN46electrostatic stabiliser, polar interaction
DALA51electrostatic stabiliser, polar interaction
DHIS148hydrogen bond acceptor, proton acceptor, proton donor
DASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA5
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
EASN46electrostatic stabiliser, polar interaction
EALA51electrostatic stabiliser, polar interaction
EHIS148hydrogen bond acceptor, proton acceptor, proton donor
EASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA6
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
FASN46electrostatic stabiliser, polar interaction
FALA51electrostatic stabiliser, polar interaction
FHIS148hydrogen bond acceptor, proton acceptor, proton donor
FASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA7
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
GASN46electrostatic stabiliser, polar interaction
GALA51electrostatic stabiliser, polar interaction
GHIS148hydrogen bond acceptor, proton acceptor, proton donor
GASP163electrostatic stabiliser, hydrogen bond donor

site_idMCSA8
Number of Residues4
DetailsM-CSA 746
ChainResidueDetails
HASN46electrostatic stabiliser, polar interaction
HALA51electrostatic stabiliser, polar interaction
HHIS148hydrogen bond acceptor, proton acceptor, proton donor
HASP163electrostatic stabiliser, hydrogen bond donor

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数据于2024-09-18公开中

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