Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1OO5

Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
A0004155molecular_function6,7-dihydropteridine reductase activity
A0005829cellular_componentcytosol
A0010181molecular_functionFMN binding
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0046256biological_process2,4,6-trinitrotoluene catabolic process
A0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
B0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
B0004155molecular_function6,7-dihydropteridine reductase activity
B0005829cellular_componentcytosol
B0010181molecular_functionFMN binding
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0046256biological_process2,4,6-trinitrotoluene catabolic process
B0046857molecular_functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
PDBデータベースに由来する情報
site_idAC1
残基数20
詳細BINDING SITE FOR RESIDUE FMN A 218
鎖名残基
AARG10
AGLY166
ALYS205
AARG207
AHOH224
AHOH236
BPRO38
BSER39
BSER40
BASN42
BGLN142
AHIS11
BLEU145
ASER12
ALYS14
AASN71
ALYS74
APRO163
AILE164
AGLU165

site_idAC2
残基数20
詳細BINDING SITE FOR RESIDUE FMN B 219
鎖名残基
APRO38
ASER39
ASER40
AASN42
AGLN142
ALEU145
BARG10
BHIS11
BSER12
BLYS14
BASN71
BLYS74
BPRO163
BGLU165
BGLY166
BASN200
BLYS205
BARG207
BHOH233
BHOH247

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数6
詳細BINDING: BINDING => ECO:0000269|PubMed:11020276, ECO:0000269|PubMed:11491290, ECO:0000269|PubMed:15684426
鎖名残基詳細
AARG10
AGLU165
ALYS205
BARG10
BGLU165
BLYS205

site_idSWS_FT_FI2
残基数10
詳細BINDING: BINDING => ECO:0000250|UniProtKB:Q01234
鎖名残基詳細
ALYS14
BARG107
ATHR41
AASN71
ALYS74
AARG107
BLYS14
BTHR41
BASN71
BLYS74

CSAにおける酵素触媒機能の情報
site_idMCSA1
残基数3
詳細M-CSA 211
鎖名残基詳細
ALYS14electrostatic stabiliser, hydrogen bond donor
ALYS74electrostatic stabiliser, hydrogen bond donor
AGLU165electrostatic stabiliser, hydrogen bond donor

site_idMCSA2
残基数3
詳細M-CSA 211
鎖名残基詳細
BLYS14electrostatic stabiliser, hydrogen bond donor
BLYS74electrostatic stabiliser, hydrogen bond donor
BGLU165electrostatic stabiliser, hydrogen bond donor

225158

件を2024-09-18に公開中

PDB statisticsPDBj update infoContact PDBjnumon