1NA1

The structure of HRV14 when complexed with Pleconaril

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GO(遺伝子オントロジー)由来の情報

鎖名GO(遺伝子オントロジー)id名前空間内容
A0044162cellular_componenthost cell cytoplasmic vesicle membrane
A0044385cellular_componentintegral to membrane of host cell
A0016020cellular_componentmembrane
A0039618cellular_componentT=pseudo3 icosahedral viral capsid
A0005524molecular_functionATP binding
A0004197molecular_functioncysteine-type endopeptidase activity
A0005216molecular_functionion channel activity
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
A0005198molecular_functionstructural molecule activity
A0006260biological_processDNA replication
A0075509biological_processendocytosis involved in viral entry into host cell
A0039520biological_processinduction by virus of host autophagy
A0039664biological_processlysis of host organelle involved in viral entry into host cell
A0039707biological_processpore formation by virus in membrane of host cell
A0044694biological_processpore-mediated entry of viral genome into host cell
A0039690biological_processpositive stranded viral RNA replication
A0051259biological_processprotein complex oligomerization
A0018144biological_processRNA-protein covalent cross-linking
A0039657biological_processsuppression by virus of host gene expression
A0039522biological_processsuppression by virus of host mRNA export from nucleus
A0039540biological_processsuppression by virus of host RIG-I activity
A0039611biological_processsuppression by virus of host translation initiation factor activity
A0006351biological_processtranscription, DNA-templated
A0039694biological_processviral RNA genome replication
A0019062biological_processvirion attachment to host cell
B0044162cellular_componenthost cell cytoplasmic vesicle membrane
B0044385cellular_componentintegral to membrane of host cell
B0016020cellular_componentmembrane
B0039618cellular_componentT=pseudo3 icosahedral viral capsid
B0005524molecular_functionATP binding
B0004197molecular_functioncysteine-type endopeptidase activity
B0005216molecular_functionion channel activity
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
B0005198molecular_functionstructural molecule activity
B0006260biological_processDNA replication
B0075509biological_processendocytosis involved in viral entry into host cell
B0039520biological_processinduction by virus of host autophagy
B0039664biological_processlysis of host organelle involved in viral entry into host cell
B0039707biological_processpore formation by virus in membrane of host cell
B0044694biological_processpore-mediated entry of viral genome into host cell
B0039690biological_processpositive stranded viral RNA replication
B0051259biological_processprotein complex oligomerization
B0018144biological_processRNA-protein covalent cross-linking
B0039657biological_processsuppression by virus of host gene expression
B0039522biological_processsuppression by virus of host mRNA export from nucleus
B0039540biological_processsuppression by virus of host RIG-I activity
B0039611biological_processsuppression by virus of host translation initiation factor activity
B0006351biological_processtranscription, DNA-templated
B0039694biological_processviral RNA genome replication
B0019062biological_processvirion attachment to host cell
C0044162cellular_componenthost cell cytoplasmic vesicle membrane
C0044385cellular_componentintegral to membrane of host cell
C0016020cellular_componentmembrane
C0039618cellular_componentT=pseudo3 icosahedral viral capsid
C0005524molecular_functionATP binding
C0004197molecular_functioncysteine-type endopeptidase activity
C0005216molecular_functionion channel activity
C0003723molecular_functionRNA binding
C0003724molecular_functionRNA helicase activity
C0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
C0005198molecular_functionstructural molecule activity
C0006260biological_processDNA replication
C0075509biological_processendocytosis involved in viral entry into host cell
C0039520biological_processinduction by virus of host autophagy
C0039664biological_processlysis of host organelle involved in viral entry into host cell
C0039707biological_processpore formation by virus in membrane of host cell
C0044694biological_processpore-mediated entry of viral genome into host cell
C0039690biological_processpositive stranded viral RNA replication
C0051259biological_processprotein complex oligomerization
C0018144biological_processRNA-protein covalent cross-linking
C0039657biological_processsuppression by virus of host gene expression
C0039522biological_processsuppression by virus of host mRNA export from nucleus
C0039540biological_processsuppression by virus of host RIG-I activity
C0039611biological_processsuppression by virus of host translation initiation factor activity
C0006351biological_processtranscription, DNA-templated
C0039694biological_processviral RNA genome replication
C0019062biological_processvirion attachment to host cell
D0044162cellular_componenthost cell cytoplasmic vesicle membrane
D0044385cellular_componentintegral to membrane of host cell
D0016020cellular_componentmembrane
D0039618cellular_componentT=pseudo3 icosahedral viral capsid
D0005524molecular_functionATP binding
D0004197molecular_functioncysteine-type endopeptidase activity
D0005216molecular_functionion channel activity
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0003968molecular_functionRNA-directed 5'-3' RNA polymerase activity
D0005198molecular_functionstructural molecule activity
D0006260biological_processDNA replication
D0075509biological_processendocytosis involved in viral entry into host cell
D0039520biological_processinduction by virus of host autophagy
D0039664biological_processlysis of host organelle involved in viral entry into host cell
D0039707biological_processpore formation by virus in membrane of host cell
D0044694biological_processpore-mediated entry of viral genome into host cell
D0039690biological_processpositive stranded viral RNA replication
D0051259biological_processprotein complex oligomerization
D0018144biological_processRNA-protein covalent cross-linking
D0039657biological_processsuppression by virus of host gene expression
D0039522biological_processsuppression by virus of host mRNA export from nucleus
D0039540biological_processsuppression by virus of host RIG-I activity
D0039611biological_processsuppression by virus of host translation initiation factor activity
D0006351biological_processtranscription, DNA-templated
D0039694biological_processviral RNA genome replication
D0019062biological_processvirion attachment to host cell
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PDBデータベースに由来する情報

site_id残基数詳細
AC112BINDING SITE FOR RESIDUE W11 A 7001
鎖名残基
ALEU106
ATYR128
AALA150
ATYR152
APRO174
ASER175
AVAL176
APHE186
ATYR197
AASN219
AMET224
CALA24

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「HETATM」原子の座標から抽出されたリガンド結合部位

site_id残基数詳細
W11_1na1_A_7001223-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE binding site
鎖名残基ligand
ATRP102W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AILE104-LEU106W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ASER126W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ATYR128W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AILE130W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AALA150-TYR152W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
APRO174-VAL176W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
APHE186W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AVAL188W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AVAL191W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
ATYR197W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AASN219W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AMET221W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
AMET224W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE
CALA24-LEU25W11: 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id残基数詳細
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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id残基数詳細
SWS_FT_FI13For Protease 2A activity. {ECO:0000250}.
鎖名残基詳細
ANA*
ANA*
ANA*

SWS_FT_FI21For Protease 3C activity. {ECO:0000250}.
鎖名残基詳細
ANA*

SWS_FT_FI32For Protease 3C activity. {ECO:0000255}.
鎖名残基詳細
ANA*
ANA*

SWS_FT_FI41For RdRp activity. {ECO:0000250}.
鎖名残基詳細
ANA*

SWS_FT_FI52Cleavage; by Protease 2A. {ECO:0000255}.
鎖名残基詳細
ANA*

SWS_FT_FI62Cleavage; by autolysis. {ECO:0000255}.
鎖名残基詳細
ANA*

SWS_FT_FI712Cleavage; by Protease 3C. {ECO:0000255}.
鎖名残基詳細
ANA*
ANA*
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI83For Protease 2A activity. {ECO:0000250}.
鎖名残基詳細
BNA*
BNA*
BNA*

SWS_FT_FI91For Protease 3C activity. {ECO:0000250}.
鎖名残基詳細
BNA*

SWS_FT_FI102For Protease 3C activity. {ECO:0000255}.
鎖名残基詳細
BNA*
BNA*

SWS_FT_FI111For RdRp activity. {ECO:0000250}.
鎖名残基詳細
BNA*

SWS_FT_FI122Cleavage; by Protease 2A. {ECO:0000255}.
鎖名残基詳細
BNA*

SWS_FT_FI132Cleavage; by autolysis. {ECO:0000255}.
鎖名残基詳細
BNA*

SWS_FT_FI1412Cleavage; by Protease 3C. {ECO:0000255}.
鎖名残基詳細
BGLN262
BNA*
BNA*
BNA*
BNA*
BNA*

SWS_FT_FI153For Protease 2A activity. {ECO:0000250}.
鎖名残基詳細
CNA*
CNA*
CNA*

SWS_FT_FI161For Protease 3C activity. {ECO:0000250}.
鎖名残基詳細
CNA*

SWS_FT_FI172For Protease 3C activity. {ECO:0000255}.
鎖名残基詳細
CNA*
CNA*

SWS_FT_FI181For RdRp activity. {ECO:0000250}.
鎖名残基詳細
CNA*

SWS_FT_FI192Cleavage; by Protease 2A. {ECO:0000255}.
鎖名残基詳細
CNA*

SWS_FT_FI202Cleavage; by autolysis. {ECO:0000255}.
鎖名残基詳細
CNA*

SWS_FT_FI2112Cleavage; by Protease 3C. {ECO:0000255}.
鎖名残基詳細
CNA*
CNA*
CNA*
CNA*
CNA*
CNA*

SWS_FT_FI223For Protease 2A activity. {ECO:0000250}.
鎖名残基詳細
DNA*
DNA*
DNA*

SWS_FT_FI231For Protease 3C activity. {ECO:0000250}.
鎖名残基詳細
DNA*

SWS_FT_FI242For Protease 3C activity. {ECO:0000255}.
鎖名残基詳細
DNA*
DNA*

SWS_FT_FI251For RdRp activity. {ECO:0000250}.
鎖名残基詳細
DNA*

SWS_FT_FI262Cleavage; by Protease 2A. {ECO:0000255}.
鎖名残基詳細
DNA*

SWS_FT_FI272Cleavage; by autolysis. {ECO:0000255}.
鎖名残基詳細
DASN68

SWS_FT_FI2812Cleavage; by Protease 3C. {ECO:0000255}.
鎖名残基詳細
DNA*
DNA*
DNA*
DNA*
DNA*
DNA*

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CSAにおける酵素触媒機能の情報

site_id残基数詳細