1IKA

STRUCTURE OF ISOCITRATE DEHYDROGENASE WITH ALPHA-KETOGLUTARATE AT 2.7 ANGSTROMS RESOLUTION: CONFORMATIONAL CHANGES INDUCED BY DECARBOXYLATION OF ISOCITRATE

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GO(遺伝子オントロジー)由来の情報

鎖名GO(遺伝子オントロジー)id名前空間内容
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0004450molecular_functionisocitrate dehydrogenase (NADP+) activity
A0000287molecular_functionmagnesium ion binding
A0051287molecular_functionNAD binding
A0022900biological_processelectron transport chain
A0006097biological_processglyoxylate cycle
A0006979biological_processresponse to oxidative stress
A0006099biological_processtricarboxylic acid cycle
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PDBデータベースに由来する情報

site_id残基数詳細
AC13BINDING SITE FOR RESIDUE CA A 417
鎖名残基
AASP307
AASP311
AAKG418

AC29BINDING SITE FOR RESIDUE AKG A 418
鎖名残基
ASER113
AASN115
AARG119
AARG129
ALYS230
AASP283
AASP307
AASP311
ACA417

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「HETATM」原子の座標から抽出されたリガンド結合部位

site_id残基数詳細
AKG_1ika_A_41882-OXOGLUTARIC ACID binding site
鎖名残基ligand
ASER113AKG: 2-OXOGLUTARIC ACID
AASN115AKG: 2-OXOGLUTARIC ACID
AARG119AKG: 2-OXOGLUTARIC ACID
AARG129AKG: 2-OXOGLUTARIC ACID
AARG153AKG: 2-OXOGLUTARIC ACID
AASP307AKG: 2-OXOGLUTARIC ACID
AASP311AKG: 2-OXOGLUTARIC ACID
ATHR338AKG: 2-OXOGLUTARIC ACID

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id残基数詳細
PS0047020Isocitrate and isopropylmalate dehydrogenases signature. [NSK]-[LIMYTV]-[FYDNH]-[GEA]-[DNGSTY]-[IMVYL]-x-[STGDN]-[DN]-x(1,2)
鎖名残基詳細
AASN303-ILE322

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id残基数詳細
SWS_FT_FI11Magnesium or manganese
鎖名残基詳細
AASP307

SWS_FT_FI21NADP; via amide nitrogen and carbonyl oxygen.
鎖名残基詳細
AASN352

SWS_FT_FI35Substrate.
鎖名残基詳細
ASER113
AASN115
AARG119
AARG129
AARG153

SWS_FT_FI43NADP.
鎖名残基詳細
ATHR104
ATYR391
AARG395

SWS_FT_FI52Critical for catalysis.
鎖名残基詳細
ATYR160
ALYS230

SWS_FT_FI67NADP.
鎖名残基詳細
AHIS339-TYR345

extCATRES13Mapped from 1a05 to 1ika using BLAST. All catalytic residues present. Original details record follows: a catalytic site defined by CATRES, Medline 91363356, 94009683, 94188357, 94330710, 95119012
鎖名残基詳細
ATYR140acid/base. acid donating proton to CH group
BASP222acid/base. base abstracting proton from OH group before hydride transfer
BLYS190acid/base. acid donating proton to CH group

CSA11Annotated By Reference To The Literature 1a05
鎖名残基詳細
ATYR160

CSA22Annotated By Reference To The Literature 1a05
鎖名残基詳細
AASP283
ALYS230

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CSAにおける酵素触媒機能の情報

site_id残基数詳細
CSA11Annotated By Reference To The Literature 1a05
鎖名残基詳細
ATYR160

CSA22Annotated By Reference To The Literature 1a05
鎖名残基詳細
AASP283
ALYS230