1H0D
Crystal structure of Human Angiogenin in complex with Fab fragment of its monoclonal antibody mAb 26-2F
Functional Information from GO Data
Chain | GOid | namespace | contents |
C | 0001525 | biological_process | angiogenesis |
C | 0001541 | biological_process | ovarian follicle development |
C | 0001556 | biological_process | oocyte maturation |
C | 0001666 | biological_process | response to hypoxia |
C | 0001890 | biological_process | placenta development |
C | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0003677 | molecular_function | DNA binding |
C | 0003779 | molecular_function | actin binding |
C | 0004519 | molecular_function | endonuclease activity |
C | 0004521 | molecular_function | RNA endonuclease activity |
C | 0004540 | molecular_function | RNA nuclease activity |
C | 0004549 | molecular_function | tRNA-specific ribonuclease activity |
C | 0005102 | molecular_function | signaling receptor binding |
C | 0005507 | molecular_function | copper ion binding |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005604 | cellular_component | basement membrane |
C | 0005615 | cellular_component | extracellular space |
C | 0005634 | cellular_component | nucleus |
C | 0005694 | cellular_component | chromosome |
C | 0005730 | cellular_component | nucleolus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0007154 | biological_process | cell communication |
C | 0008201 | molecular_function | heparin binding |
C | 0009303 | biological_process | rRNA transcription |
C | 0009725 | biological_process | response to hormone |
C | 0010494 | cellular_component | cytoplasmic stress granule |
C | 0015629 | cellular_component | actin cytoskeleton |
C | 0016078 | biological_process | tRNA decay |
C | 0016477 | biological_process | cell migration |
C | 0017148 | biological_process | negative regulation of translation |
C | 0019731 | biological_process | antibacterial humoral response |
C | 0019843 | molecular_function | rRNA binding |
C | 0023052 | biological_process | signaling |
C | 0030041 | biological_process | actin filament polymerization |
C | 0030139 | cellular_component | endocytic vesicle |
C | 0030154 | biological_process | cell differentiation |
C | 0030426 | cellular_component | growth cone |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0032055 | biological_process | negative regulation of translation in response to stress |
C | 0032311 | cellular_component | angiogenin-PRI complex |
C | 0034063 | biological_process | stress granule assembly |
C | 0042277 | molecular_function | peptide binding |
C | 0042327 | biological_process | positive regulation of phosphorylation |
C | 0042592 | biological_process | homeostatic process |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0043022 | molecular_function | ribosome binding |
C | 0043025 | cellular_component | neuronal cell body |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0045087 | biological_process | innate immune response |
C | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
C | 0050714 | biological_process | positive regulation of protein secretion |
C | 0050830 | biological_process | defense response to Gram-positive bacterium |
C | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
C | 0071425 | biological_process | hematopoietic stem cell proliferation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1212 |
Chain | Residue |
A | SER14 |
A | LYS106 |
A | HOH2130 |
C | SER4 |
C | ARG5 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 1216 |
Chain | Residue |
B | HOH2034 |
B | HOH2104 |
C | ARG21 |
B | GLY53 |
B | GLY54 |
B | ARG71 |
B | ILE73 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 1124 |
Chain | Residue |
A | HOH2101 |
C | HIS13 |
C | LYS40 |
C | HOH2092 |
C | HOH2093 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 1125 |
Chain | Residue |
C | ASN49 |
C | LYS50 |
C | ARG51 |
C | HOH2011 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 1126 |
Chain | Residue |
C | HIS65 |
C | ARG66 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 1127 |
Chain | Residue |
C | TYR6 |
C | LYS50 |
C | LYS54 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 1128 |
Chain | Residue |
C | ARG32 |
C | ARG33 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 1129 |
Chain | Residue |
C | LYS60 |
C | ASN63 |
C | HIS65 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 1213 |
Chain | Residue |
A | SER55 |
A | ARG208 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1214 |
Chain | Residue |
A | SER64 |
A | GLY65 |
A | SER66 |
A | HOH2055 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1215 |
Chain | Residue |
A | PRO8 |
A | ALA9 |
A | SER10 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 1216 |
Chain | Residue |
A | THR163 |
A | ASP164 |
A | ASP166 |
A | HOH2110 |
A | HOH2112 |
B | HIS164 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 1217 |
Chain | Residue |
A | GLU122 |
B | SER120 |
B | VAL121 |
B | TYR122 |
B | SER202 |
B | SER203 |
B | LYS208 |
B | HOH2098 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 1218 |
Chain | Residue |
A | GLN123 |
A | SER126 |
B | TYR122 |
B | LYS143 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
Chain | Residue | Details |
C | HIS13 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
Chain | Residue | Details |
C | HIS114 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
C | LYS40 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2866794 |
Chain | Residue | Details |
C | PCA1 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4y |
Chain | Residue | Details |
C | HIS13 | |
C | LYS40 | |
C | HIS114 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 564 |
Chain | Residue | Details |
C | HIS13 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
C | LYS40 | electrostatic stabiliser |
C | HIS114 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |