1FV1
STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
A | 0019882 | biological_process | antigen processing and presentation |
A | 0042613 | cellular_component | MHC class II protein complex |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
B | 0019882 | biological_process | antigen processing and presentation |
B | 0042613 | cellular_component | MHC class II protein complex |
C | 0019911 | molecular_function | structural constituent of myelin sheath |
D | 0006955 | biological_process | immune response |
D | 0016020 | cellular_component | membrane |
D | 0019882 | biological_process | antigen processing and presentation |
D | 0042613 | cellular_component | MHC class II protein complex |
E | 0006955 | biological_process | immune response |
E | 0016020 | cellular_component | membrane |
E | 0019882 | biological_process | antigen processing and presentation |
E | 0042613 | cellular_component | MHC class II protein complex |
F | 0019911 | molecular_function | structural constituent of myelin sheath |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 182 |
Chain | Residue |
D | ARG123 |
D | ASN124 |
D | LYS126 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 182 |
Chain | Residue |
A | ARG123 |
A | ASN124 |
A | LYS126 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 191 |
Chain | Residue |
B | HOH268 |
B | HOH278 |
E | ARG29 |
E | ARG39 |
E | HOH270 |
B | ARG29 |
B | ARG39 |
B | HOH267 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL D 183 |
Chain | Residue |
B | ARG48 |
D | ASP110 |
D | LYS111 |
D | ARG140 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 192 |
Chain | Residue |
B | ARG94 |
B | SER179 |
D | LYS67 |
D | GLU71 |
D | HOH241 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Cleavage; by CTSG => ECO:0000269|PubMed:15100291 |
Chain | Residue | Details |
C | PHE92 | |
F | PHE92 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P02688 |
Chain | Residue | Details |
C | THR97 | |
F | THR97 | |
D | GLY49 | |
D | ALA52 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Citrulline => ECO:0000269|PubMed:23828821 |
Chain | Residue | Details |
C | ARG99 | |
F | ARG99 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P02687 |
Chain | Residue | Details |
C | THR100 | |
F | THR100 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Deamidated glutamine => ECO:0000250 |
Chain | Residue | Details |
C | GLN105 | |
F | GLN105 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN62 | |
D | ASN62 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ASN69 | |
D | ASN69 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
Chain | Residue | Details |
A | ARG76 | |
D | ARG76 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
Chain | Residue | Details |
A | ASN78 | |
A | ASN118 | |
D | ASN78 | |
D | ASN118 |