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1FV1

STRUCTURAL BASIS FOR THE BINDING OF AN IMMUNODOMINANT PEPTIDE FROM MYELIN BASIC PROTEIN IN DIFFERENT REGISTERS BY TWO HLA-DR2 ALLELES

Functional Information from GO Data
ChainGOidnamespacecontents
A0006955biological_processimmune response
A0016020cellular_componentmembrane
A0019882biological_processantigen processing and presentation
A0042613cellular_componentMHC class II protein complex
B0006955biological_processimmune response
B0016020cellular_componentmembrane
B0019882biological_processantigen processing and presentation
B0042613cellular_componentMHC class II protein complex
C0019911molecular_functionstructural constituent of myelin sheath
D0006955biological_processimmune response
D0016020cellular_componentmembrane
D0019882biological_processantigen processing and presentation
D0042613cellular_componentMHC class II protein complex
E0006955biological_processimmune response
E0016020cellular_componentmembrane
E0019882biological_processantigen processing and presentation
E0042613cellular_componentMHC class II protein complex
F0019911molecular_functionstructural constituent of myelin sheath
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 D 182
ChainResidue
DARG123
DASN124
DLYS126

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 182
ChainResidue
AARG123
AASN124
ALYS126

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 191
ChainResidue
BHOH268
BHOH278
EARG29
EARG39
EHOH270
BARG29
BARG39
BHOH267

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL D 183
ChainResidue
BARG48
DASP110
DLYS111
DARG140

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 192
ChainResidue
BARG94
BSER179
DLYS67
DGLU71
DHOH241

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
ChainResidueDetails
ATYR161-HIS167
BTYR171-HIS177

site_idPS00569
Number of Residues7
DetailsMYELIN_MBP Myelin basic protein signature. VVHFFKN
ChainResidueDetails
CVAL88-ASN94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by CTSG => ECO:0000269|PubMed:15100291
ChainResidueDetails
CPHE92
FPHE92

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P02688
ChainResidueDetails
CTHR97
FTHR97
DGLY49
DALA52

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Citrulline => ECO:0000269|PubMed:23828821
ChainResidueDetails
CARG99
FARG99

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P02687
ChainResidueDetails
CTHR100
FTHR100

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Deamidated glutamine => ECO:0000250
ChainResidueDetails
CGLN105
FGLN105

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
ChainResidueDetails
AASN62
DASN62

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
ChainResidueDetails
AASN69
DASN69

site_idSWS_FT_FI8
Number of Residues2
DetailsSITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
ChainResidueDetails
AARG76
DARG76

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
ChainResidueDetails
AASN78
AASN118
DASN78
DASN118

225158

數據於2024-09-18公開中

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