1DTN
MANDELATE RACEMASE MUTANT D270N CO-CRYSTALLIZED WITH (S)-ATROLACTATE
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0009063 | biological_process | amino acid catabolic process |
| A | 0016052 | biological_process | carbohydrate catabolic process |
| A | 0016836 | molecular_function | hydro-lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0018838 | molecular_function | mandelate racemase activity |
| A | 0018924 | biological_process | mandelate metabolic process |
| A | 0019596 | biological_process | mandelate catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 360 |
| 鎖名 | 残基 |
| A | GLU247 |
| A | APG399 |
| A | HOH401 |
| A | ASP195 |
| A | GLU221 |
| site_id | AC2 |
| 残基数 | 12 |
| 詳細 | BINDING SITE FOR RESIDUE APG A 399 |
| 鎖名 | 残基 |
| A | PHE52 |
| A | TYR54 |
| A | LYS164 |
| A | LYS166 |
| A | ASP195 |
| A | ASN197 |
| A | GLU221 |
| A | GLU247 |
| A | HIS297 |
| A | GLN317 |
| A | MG360 |
| A | HOH401 |
| site_id | ACT |
| 残基数 | 2 |
| 詳細 | SITE ACT CONSTITUTES THE ACID/BASE CATALYSTS RESPONSIBLE FOR PROTON ABSTRACTION AND REDELIVERY IN THE RACEMIZATION REACTION. |
| 鎖名 | 残基 |
| A | LYS166 |
| A | HIS297 |
| site_id | CAR |
| 残基数 | 2 |
| 詳細 | SITE CAR CONSTITUTES THE BINDING SITE FOR THE CARBOXYL GROUP OF SUBSTRATE. THESE RESIDUES FUNCTION, ALONG WITH THE METAL ION, AS ELECTROPHILIC CATALYSTS. |
| 鎖名 | 残基 |
| A | LYS164 |
| A | GLN317 |
| site_id | MTL |
| 残基数 | 3 |
| 詳細 | SITE MTL CONSTITUTES THE DIRECT METAL ION LIGANDS. |
| 鎖名 | 残基 |
| A | ASP195 |
| A | GLU221 |
| A | GLU247 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: Proton acceptor; specific for S-mandelate |
| 鎖名 | 残基 | 詳細 |
| A | LYS166 |
| site_id | SWS_FT_FI2 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: Proton acceptor; specific for R-mandelate |
| 鎖名 | 残基 | 詳細 |
| A | HIS297 |
| site_id | SWS_FT_FI3 |
| 残基数 | 4 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:7893689, ECO:0000269|PubMed:7893690, ECO:0000305|PubMed:1892834 |
| 鎖名 | 残基 | 詳細 |
| A | ASP195 | |
| A | GLU221 | |
| A | GLU247 | |
| A | GLN317 |
CSAにおける酵素触媒機能の情報
| site_id | CSA1 |
| 残基数 | 4 |
| 詳細 | Annotated By Reference To The Literature 1mdr |
| 鎖名 | 残基 | 詳細 |
| A | GLN317 | |
| A | LYS166 | |
| A | HIS297 | |
| A | ASP270 |
| site_id | CSA2 |
| 残基数 | 3 |
| 詳細 | Annotated By Reference To The Literature 1mdr |
| 鎖名 | 残基 | 詳細 |
| A | LYS164 | |
| A | LYS166 | |
| A | SER324 |
| site_id | MCSA1 |
| 残基数 | 9 |
| 詳細 | M-CSA 187 |
| 鎖名 | 残基 | 詳細 |
| A | LYS164 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS166 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASP195 | metal ligand |
| A | ASN197 | electrostatic stabiliser |
| A | GLU221 | metal ligand |
| A | GLU247 | metal ligand |
| A | ASP270 | electrostatic stabiliser, hydrogen bond acceptor, increase basicity |
| A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLN317 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
