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1BP3

THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0002092biological_processpositive regulation of receptor internalization
A0005125molecular_functioncytokine activity
A0005131molecular_functiongrowth hormone receptor binding
A0005148molecular_functionprolactin receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0010828biological_processpositive regulation of glucose transmembrane transport
A0019221biological_processcytokine-mediated signaling pathway
A0031667biological_processresponse to nutrient levels
A0031904cellular_componentendosome lumen
A0032355biological_processresponse to estradiol
A0040018biological_processpositive regulation of multicellular organism growth
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0043406biological_processpositive regulation of MAP kinase activity
A0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
A0045927biological_processpositive regulation of growth
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0048513biological_processanimal organ development
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060396biological_processgrowth hormone receptor signaling pathway
A0062023cellular_componentcollagen-containing extracellular matrix
A0070186molecular_functiongrowth hormone activity
A0070195cellular_componentgrowth hormone receptor complex
A0070977biological_processbone maturation
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
PDBデータベースに由来する情報
site_idAC1
残基数4
詳細BINDING SITE FOR RESIDUE ZN A 500
鎖名残基
AHIS18
AGLU174
BASP387
BHIS388

site_idZNA
残基数4
詳細ZINC BINDING SITE BETWEEN HGH AND PROLACTIN RECEPTOR.
鎖名残基
AHIS18
AGLU174
BASP387
BHIS388

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00266
残基数34
詳細SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CfSesIpTPsnreeTqqksnleLlrisllLiqSW
鎖名残基詳細
ACYS53-TRP86

site_idPS00338
残基数18
詳細SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CFRkDMdKVEtFlrIvqC
鎖名残基詳細
ACYS165-CYS182

site_idPS01352
残基数78
詳細HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdhgy....WsaWspatfI
鎖名残基詳細
BLEU323-ILE400

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数209
詳細TOPO_DOM: Extracellular => ECO:0000255
鎖名残基詳細
BGLN201-ASP410
AGLU174

site_idSWS_FT_FI2
残基数2
詳細BINDING:
鎖名残基詳細
BASP387
BHIS388

site_idSWS_FT_FI3
残基数3
詳細CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
鎖名残基詳細
BASN235
BASN280
BASN409

site_idSWS_FT_FI4
残基数1
詳細MOD_RES: Deamidated asparagine; by deterioration => ECO:0000269|PubMed:7028740
鎖名残基詳細
AASN152

218853

件を2024-04-24に公開中

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