9WZY

Crystal Structure of BRD4 BD1 Domain Complexed with a Molecular Glue Probe

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SSRF BEAMLINE BL10U2
Synchrotron site	SSRF
Beamline	BL10U2
Temperature [K]	100
Detector technology	PIXEL
Collection date	2025-04-18
Detector	DECTRIS EIGER X 16M
Wavelength(s)	0.97918
Spacegroup name	P 21 21 21
Unit cell lengths	34.530, 47.229, 78.055
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	39.030 - 2.620
Rwork	0.232
R-free	0.30520
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.009
RMSD bond angle	1.216
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHENIX
Refinement software	PHENIX ((1.20.1_4487: ???))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	39.030	2.714
High resolution limit [Å]	2.620	2.620
Number of reflections	4143	404
<I/σ(I)>	16.79
Completeness [%]	99.7	100
Redundancy	11.5
CC(1/2)	0.996	0.994

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		291	3.8 M sodium formate and 10% glycerol