9T3Q
Crystal structure of D1228V c-MET bound by cabozantinib.
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04 |
| Synchrotron site | Diamond |
| Beamline | I04 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2024-02-19 |
| Detector | DECTRIS EIGER X 16M |
| Wavelength(s) | 0.95373 |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 42.476, 79.845, 91.630 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 60.200 - 1.629 |
| R-factor | 0.1991 |
| Rwork | 0.197 |
| R-free | 0.23820 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.010 |
| RMSD bond angle | 0.940 |
| Data reduction software | autoPROC |
| Data scaling software | autoPROC |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 60.200 | 1.860 |
| High resolution limit [Å] | 1.630 | 1.630 |
| Number of reflections | 21924 | 1096 |
| <I/σ(I)> | 9.8 | |
| Completeness [%] | 92.0 | |
| Redundancy | 6.2 | |
| CC(1/2) | 0.998 | 0.552 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 20% PEG4K, 10% isopropanol, 0.1 M Na-HEPES pH 7.5 |
