9SZJ

Crystal structure of Y1230H c-MET bound by capmatinib.

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SOLEIL BEAMLINE PROXIMA 2
Synchrotron site	SOLEIL
Beamline	PROXIMA 2
Temperature [K]	100
Detector technology	PIXEL
Collection date	2024-03-28
Detector	DECTRIS EIGER X 16M
Wavelength(s)	0.98011
Spacegroup name	P 21 21 21
Unit cell lengths	42.264, 43.386, 158.328
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	79.160 - 2.289
R-factor	0.2339
Rwork	0.230
R-free	0.30370
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.007
RMSD bond angle	0.890
Data reduction software	autoPROC
Data scaling software	autoPROC
Phasing software	PHASER
Refinement software	BUSTER (2.11.8)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	158.330	2.580
High resolution limit [Å]	2.290	2.290
Number of reflections	7450	372
<I/σ(I)>	4.8
Completeness [%]	82.7
Redundancy	6.2
CC(1/2)	0.974	0.361

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	Morpheus HT-96 (MD1-47) condition D10