8XRR

A complex structure of PDGFRA with an inhibitor RH140

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SSRF BEAMLINE BL18U1
Synchrotron site	SSRF
Beamline	BL18U1
Temperature [K]	100
Detector technology	PIXEL
Collection date	2023-12-25
Detector	DECTRIS PILATUS3 S 6M
Wavelength(s)	0.9785
Spacegroup name	P 21 21 21
Unit cell lengths	53.970, 72.990, 99.550
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	36.590 - 2.570
R-factor	0.2383
Rwork	0.236
R-free	0.25950
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	6a32
RMSD bond length	0.008
RMSD bond angle	1.096
Data reduction software	xia2
Data scaling software	xia2
Phasing software	PHENIX
Refinement software	PHENIX ((1.20.1_4487: ???))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	36.590	2.640
High resolution limit [Å]	2.570	2.570
Number of reflections	13017	948
<I/σ(I)>	1.3
Completeness [%]	99.9
Redundancy	25.7
CC(1/2)	0.998	0.729

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		293	0.1 M HEPES, pH 7.5, 20% PEG 4000