8OUV

Crystal structure of D1228V c-MET bound by compound 15

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I04
Synchrotron site	Diamond
Beamline	I04
Temperature [K]	293
Detector technology	PIXEL
Collection date	2017-06-23
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.979500
Spacegroup name	P 21 21 21
Unit cell lengths	53.772, 56.229, 215.948
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	107.970 - 1.783
R-factor	0.1926
Rwork	0.191
R-free	0.21970
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.009
RMSD bond angle	0.910
Data reduction software	XDS
Data scaling software	XSCALE
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	200.000	1.813
High resolution limit [Å]	1.783	1.783
Number of reflections	62697	2722
<I/σ(I)>	16.1
Completeness [%]	98.6
Redundancy	6.1
CC(1/2)	0.999	0.914

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION		293	30 % PEG400, 0.1 M CaCl2, 0.1 M PCPT pH 4.5.