7B40
Crystal structure of c-MET bound by compound 6
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | SLS BEAMLINE X06SA |
| Synchrotron site | SLS |
| Beamline | X06SA |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2020-08-31 |
| Detector | DECTRIS PILATUS 2M |
| Wavelength(s) | 0.99987 |
| Spacegroup name | C 1 2 1 |
| Unit cell lengths | 109.930, 42.470, 86.080 |
| Unit cell angles | 90.00, 120.94, 90.00 |
Refinement procedure
| Resolution | 47.140 - 1.760 |
| R-factor | 0.198 |
| Rwork | 0.196 |
| R-free | 0.23200 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | internal |
| RMSD bond length | 0.010 |
| RMSD bond angle | 0.970 |
| Data reduction software | XDS |
| Data scaling software | XSCALE |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.7) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 47.147 | 1.790 |
| High resolution limit [Å] | 1.760 | 1.760 |
| Number of reflections | 31621 | 1656 |
| <I/σ(I)> | 7.9 | |
| Completeness [%] | 92.9 | |
| Redundancy | 4.9 | |
| CC(1/2) | 0.995 | 0.474 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 20 % PEG4000, 10 % isopropanol, 0.1 M Na-HEPES pH 7.5 |
