Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

6Q3Y

Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16i

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsBESSY BEAMLINE 14.2
Synchrotron siteBESSY
Beamline14.2
Temperature [K]100
Detector technologyPIXEL
Collection date2018-07-14
DetectorDECTRIS PILATUS 2M
Wavelength(s)0.918400
Spacegroup nameP 1
Unit cell lengths30.340, 39.530, 56.030
Unit cell angles83.93, 75.64, 89.75
Refinement procedure
Resolution39.300 - 1.200
R-factor0.14318
Rwork0.142
R-free0.17595
Structure solution methodMOLECULAR REPLACEMENT
Starting model (for MR)2oss
RMSD bond length0.013
RMSD bond angle1.499
Data reduction softwareiMOSFLM
Data scaling softwareAimless
Phasing softwarePHASER
Refinement softwareREFMAC (5.8.0238)
Data quality characteristics
 OverallOuter shell
Low resolution limit [Å]39.3001.220
High resolution limit [Å]1.2001.200
Rmerge0.055
Number of reflections651533007
<I/σ(I)>9.6
Completeness [%]83.076.9
Redundancy3.7
CC(1/2)0.886
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, SITTING DROP6.529330% pentaerythritol ethoxylate 15/4, 0.05 ammonium sulfate, 0.1M bis-tris pH6.5

238895

PDB entries from 2025-07-16

PDB statisticsPDBj update infoContact PDBjnumon