5FW6

Structure of human transthyretin mutant A108V

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ALBA BEAMLINE XALOC
Synchrotron site	ALBA
Beamline	XALOC
Temperature [K]	100
Detector technology	CCD
Detector	RIGAKU CCD
Spacegroup name	P 21 2 21
Unit cell lengths	43.692, 64.923, 85.027
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	64.920 - 1.300
R-factor	0.17124
Rwork	0.170
R-free	0.20294
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	NONE
RMSD bond length	0.030
RMSD bond angle	2.403
Refinement software	REFMAC (5.5.0109)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	43.690	1.370
High resolution limit [Å]	1.300	1.300
Rmerge	0.040	0.500
Number of reflections	60275
<I/σ(I)>	22.9	3.6
Completeness [%]	99.8	98.8
Redundancy	6.5	6.2

Crystallization Conditions

crystal ID	method	pH	temperature	details
1