44AD

Crystal structure of FGFR1 with CPL304110

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	PHOTON FACTORY BEAMLINE BL-1A
Synchrotron site	Photon Factory
Beamline	BL-1A
Temperature [K]	100
Detector technology	PIXEL
Collection date	2026-02-06
Detector	DECTRIS EIGER X 4M
Wavelength(s)	1.000
Spacegroup name	C 1 2 1
Unit cell lengths	212.246, 51.384, 65.664
Unit cell angles	90.00, 107.12, 90.00

Refinement procedure

Resolution	46.740 - 1.970
R-factor	0.2031
Rwork	0.202
R-free	0.23720
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.006
RMSD bond angle	0.803
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	PHENIX (2.0_5885)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	49.810	2.090
High resolution limit [Å]	1.970	1.970
Number of reflections	44080	14195
<I/σ(I)>	13.1
Completeness [%]	92.3
Redundancy	3.56
CC(1/2)	0.998	0.805

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		295	0.2 M L-proline 0.1 M HEPES, pH 7.5 12% (w/v) PEG 3350