3L8V
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor
Experimental procedure
| 実験手法 | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | APS BEAMLINE 17-ID |
| Synchrotron site | APS |
| Beamline | 17-ID |
| Temperature [K] | 100 |
| Detector technology | CCD |
| Collection date | 2005-12-10 |
| Detector | ADSC QUANTUM 210 |
| Wavelength(s) | 1.0000 |
| Spacegroup name | P 21 21 21 |
| 格子定数 [Å] | 42.800, 47.250, 154.500 |
| 格子定数 [度] | 90.00, 90.00, 90.00 |
精密化法
| 残基 | 45.180 - 2.400 |
| Rwork | 0.185 |
| R-free | 0.23690 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | 3c1x |
| 結合長の平均二乗偏差(RMSD) [Å] | 0.010 |
| 結合角の平均二乗偏差(RMSD) [度] | 1.160 |
| Data reduction software | MOSFLM |
| Data scaling software | SCALA |
| Refinement software | BUSTER (2.9.1) |
Quality characteristics
| Overall | Outer shell | |
| 分解能 [Å] (低) | 47.250 | 2.530 |
| 分解能 [Å] (高) | 2.400 | 2.400 |
| Rmerge_l_obs | 0.059 | 0.111 |
| 独立反射数 | 12397 | |
| <I/σ(I)> | 21.9 | 11.5 |
| 完全性 [%] | 96.6 | 80.1 |
| 冗長性 | 6.7 | 6 |
結晶化条件
| 結晶ID | 方法 | pH | 温度 | 溶液条件 |
| 1 |
