3LFN

Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	EMBL/DESY, HAMBURG BEAMLINE X11
Synchrotron site	EMBL/DESY, HAMBURG
Beamline	X11
Wavelength(s)	0.81
Spacegroup name	P 21 21 21
Unit cell lengths	53.337, 72.066, 71.439
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	18.670 - 2.280
R-factor	0.19
Rwork	0.184
R-free	0.26800
Structure solution method	FOURIER SYNTHESIS
Data reduction software	XDS
Data scaling software	XSCALE
Refinement software	TNT

Data quality characteristics

	Overall
Low resolution limit [Å]	18.670
High resolution limit [Å]	2.280
Number of reflections	13041

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP	7.4	277	pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 277K