3DKF

Structure of MET receptor tyrosine kinase in complex with inhibitor SGX-523

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	APS BEAMLINE 31-ID
Synchrotron site	APS
Beamline	31-ID
Temperature [K]	100
Detector technology	CCD
Collection date	2007-01-19
Detector	MAR CCD 165 mm
Wavelength(s)	0.97969
Spacegroup name	P 21 21 21
Unit cell lengths	43.089, 46.679, 158.482
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	34.986 - 1.800
Rwork	0.191
R-free	0.23300
Data scaling software	SCALA (3.2.5)
Refinement software	REFMAC

Data quality characteristics

	Overall
Low resolution limit [Å]	34.986
High resolution limit [Å]	1.800
Rmerge	0.055
Number of reflections	24264
<I/σ(I)>	11.3
Completeness [%]	79.7
Redundancy	4.3

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION	7.5	292	20% ISOPROPANOL, 200 mM AMMONIUM ACETATE, 100 mM TRIS, pH 7.5, VAPOR DIFFUSION, temperature 292K