1O6R
Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | ROTATING ANODE |
| Source details | RIGAKU RU200B |
| Temperature [K] | 298 |
| Detector technology | AREA DETECTOR |
| Detector | SIEMENS |
| Spacegroup name | P 32 2 1 |
| Unit cell lengths | 140.627, 140.627, 244.030 |
| Unit cell angles | 90.00, 90.00, 120.00 |
Refinement procedure
| Resolution | 25.000 - 2.700 |
| R-factor | 0.193 |
| Rwork | 0.193 |
| R-free | 0.23600 |
| Structure solution method | OTHER |
| RMSD bond length | 0.009 |
| RMSD bond angle | 1.350 |
| Data reduction software | XDS |
| Data scaling software | SCALA |
| Refinement software | CNS (1.1) |
Data quality characteristics
| Overall | |
| Low resolution limit [Å] | 43.030 |
| High resolution limit [Å] | 2.700 |
| Rmerge | 0.074 |
| Number of reflections | 62020 |
| <I/σ(I)> | 7.9 |
| Completeness [%] | 80.6 |
| Redundancy | 2.5 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | 4.8 | pH 4.80 |
