1HPS
RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE
Experimental procedure
| Spacegroup name | P 61 |
| Unit cell lengths | 63.000, 63.000, 83.300 |
| Unit cell angles | 90.00, 90.00, 120.00 |
Refinement procedure
| Resolution | 6.000 - 2.300 |
| R-factor | 0.194 |
| RMSD bond length | 0.019 |
| RMSD bond angle | 3.860 |
| Phasing software | X-PLOR |
| Refinement software | PROLSQ |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | Vapor diffusion, hanging drop * | 5 * |
Crystallization Reagents in Literatures
| ID | crystal ID | solution | reagent name | concentration (unit) | details |
| 1 | 1 | drop | acetate | 200 (mM) | |
| 2 | 1 | reservoir | ammonium sulfate | 18-26 (%sat) |
