1G5S

CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Source details	RIGAKU RU200
Temperature [K]	277
Detector technology	IMAGE PLATE
Collection date	1997-08-28
Detector	RIGAKU RAXIS IIC
Spacegroup name	P 21 21 21
Unit cell lengths	54.180, 72.840, 73.470
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	50.000 - 2.610
R-factor	0.201 *
Rwork	0.201
R-free	0.24200
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	3bmp
RMSD bond length	0.007
RMSD bond angle	1.600
Data scaling software	SCALEPACK
Phasing software	X-PLOR
Refinement software	CNS

Data quality characteristics

	Overall	Outer shell
High resolution limit [Å]	2.610 *
Rmerge	0.048 *	0.333 *
Total number of observations	47878 *
Number of reflections	10442 *
Completeness [%]	99.8 *	99.9 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	other *			Rosenblatt, J., (1993) J. Mol. Biol., 230, 1317. *