9NBP
 
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9NBQ
 | | MicroED structure of papain co-crystallized with E-64D | | Descriptor: | Papain, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate | | Authors: | Vlahakis, N, Rodriguez, J.A. | | Deposit date: | 2025-02-14 | | Release date: | 2025-03-26 | | Last modified: | 2025-08-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9NC1
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9NCA
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9NCC
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9NLV
 | | Cryo-EM structure of hexameric SenDRT9 RT-ncRNA complex | | Descriptor: | RNA (147-MER), RNA-dependent DNA polymerase | | Authors: | Burman, N, Pandey, S, Wiedenheft, B, Sternberg, S.H. | | Deposit date: | 2025-03-03 | | Release date: | 2025-05-14 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Protein-primed homopolymer synthesis by an antiviral reverse transcriptase.
Nature, 643, 2025
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9NLX
 | | Cryo-EM structure of the trimeric SenDRT9 RT-ncRNA complex (GST fusion) | | Descriptor: | RNA (147-MER), RNA-dependent DNA polymerase | | Authors: | Burman, N, Pandey, S, Wiedenheft, B, Sternberg, S.H. | | Deposit date: | 2025-03-03 | | Release date: | 2025-05-14 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Protein-primed homopolymer synthesis by an antiviral reverse transcriptase.
Nature, 643, 2025
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9NS9
 | | Cryo-EM structure of Gi-coupled FFA2 in complex with TUG-1375 and compound 187 | | Descriptor: | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid, 4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-7-(2-fluorobenzene-1-sulfonyl)-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-6-amine, Free fatty acid receptor 2, ... | | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | | Deposit date: | 2025-03-16 | | Release date: | 2025-06-25 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Allosteric modulation and biased signalling at free fatty acid receptor 2.
Nature, 643, 2025
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9NZH
 | | Crystal Structure of Amylin-NHO-18 binder complex | | Descriptor: | Amylin-NHO-18 Binder, Islet amyloid polypeptide, SULFATE ION | | Authors: | Bera, A.K, Lui, C, Kang, A, Baker, D. | | Deposit date: | 2025-03-31 | | Release date: | 2025-05-14 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Diffusing protein binders to intrinsically disordered proteins.
Nature, 2025
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9O55
 | | Structure of a synthetic antibody (RM010) in complex with a class I MHC presenting a hapten-peptide conjugate | | Descriptor: | GTPase KRas, N-terminally processed, MHC class I antigen, ... | | Authors: | Hu, Z, Rajak, E, Maso, L, Koide, S. | | Deposit date: | 2025-04-09 | | Release date: | 2025-07-23 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9O60
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9O61
 | | R-phycoerythrin | | Descriptor: | PHYCOERYTHROBILIN, PHYCOUROBILIN, R-phycoerythrin class I alpha subunit, ... | | Authors: | Rashleigh, L, Venugopal, H, Rossjohn, J, Gully, B.S. | | Deposit date: | 2025-04-10 | | Release date: | 2025-08-06 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (1.68 Å) | | Cite: | Antibody-like recognition of a gamma delta T cell receptor toward a foreign antigen.
Structure, 2025
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9O62
 | | 1C5H TCR bound to R-phycoerythrin | | Descriptor: | 1C5H TCR delta chain, PHYCOERYTHROBILIN, PHYCOUROBILIN, ... | | Authors: | Rashleigh, L, Venugopal, H, Rossjohn, J, Gully, B.S. | | Deposit date: | 2025-04-10 | | Release date: | 2025-08-06 | | Last modified: | 2025-08-13 | | Method: | ELECTRON MICROSCOPY (2.03 Å) | | Cite: | Antibody-like recognition of a gamma delta T cell receptor toward a foreign antigen.
Structure, 2025
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9O6S
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9O6T
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9O8W
 | | Crystal structure of an MKP5 mutant, Y435F, in complex with an allosteric inhibitor | | Descriptor: | 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one, Dual specificity protein phosphatase 10, SULFATE ION | | Authors: | Manjula, R, Bennett, A.M, Lolis, E. | | Deposit date: | 2025-04-16 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.
Nat Commun, 16, 2025
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9OQE
 | | X-ray diffraction structure of apo-form CTX-M-14 beta-lactamase | | Descriptor: | Beta-lactamase, PHOSPHATE ION, POTASSIUM ION | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-20 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9OR3
 | | X-ray diffraction structure of CTX-M-14 beta-lactamase co-crystallized with avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, GLYCEROL, ... | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-21 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9OR7
 | | X-ray diffraction structure of CTX-M-14 beta-lactamase soaked with avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, PHOSPHATE ION | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-21 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ORB
 | | X-ray diffraction structure of the CTX-M-14 beta-lactamase-avibactam complex an inhibitor cocktail-soaked crystal | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, PHOSPHATE ION | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-21 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ORG
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9ORH
 | | MicroED structure of the CTX-M-14 beta-lactamase-avibactam complex from inhibitor cocktail-soaked crystals | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | Authors: | Vlahakis, N, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-22 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (2 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ORL
 | | MicroED structure of CTX-M-14 beta-lactamase soaked with avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-22 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ORS
 | | MicroED structure of CTX-M-14 beta-lactamase co-crystallized with avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | Authors: | Vlahakis, N.W, Rodriguez, J.A, Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2025-05-22 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (2 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ORV
 | | X-ray diffraction structure of lysozyme co-crystallized with N,N',N"-triacetylchitotriose | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Lysozyme C, ... | | Authors: | Flowers, C.W, Vlahakis, N.W, Rodriguez, J.A. | | Deposit date: | 2025-05-22 | | Release date: | 2025-06-18 | | Last modified: | 2025-08-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes.
Proc.Natl.Acad.Sci.USA, 122, 2025
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