8QMW
| Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8S8 complex with substitutions R269W, E271R, L273N | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... | 著者 | Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2023-09-25 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Layered entrenchment maintains essentiality in protein-protein interactions Embo J., 2024
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8QNL
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8QNQ
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8QOC
| Crystal structure of Staphylococcus aureus PLP Synthase (Pdx1) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Ullah, N, Wrenger, C, Betzel, C. | 登録日 | 2023-09-28 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structure and dynamics of the staphylococcal pyridoxal 5-phosphate synthase complex reveal transient interactions at the enzyme interface. J.Biol.Chem., 300, 2024
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8R1M
| Structure of TxGH116 with covalently bound N-azido-octyl aziridine | 分子名称: | (1R,2R,3R,4S)-4-[8-(azanyldiazenyl)octylamino]-3-(hydroxymethyl)cyclopentane-1,2-diol, CALCIUM ION, CHLORIDE ION, ... | 著者 | Offen, W.A, Davies, G.J. | 登録日 | 2023-11-02 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Selective labelling of GBA2 in cells with fluorescent beta-d-arabinofuranosyl cyclitol aziridines. Chem Sci, 2024
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8R7W
| Kras G12D in complex with compound 3 | 分子名称: | 8-(furan-3-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Zak, K.M, Kessler, D. | 登録日 | 2023-11-27 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.161 Å) | 主引用文献 | Kras G12D in complex with compound 3 To Be Published
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8R7X
| Kras G12D in complex with compound 4 | 分子名称: | 8-pyridin-4-yl-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Zak, K.M. | 登録日 | 2023-11-27 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.314 Å) | 主引用文献 | Kras G12D in complex with compound 4 To Be Published
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8RIU
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8RJA
| Crystal structure of the F420-reducing formylmethanofuran dehydrogenase complex from the ethanotroph Candidatus Ethanoperedens thermophilum | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... | 著者 | Lemaire, O.N, Wagner, T. | 登録日 | 2023-12-20 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | F420 reduction as a cellular driver for anaerobic ethanotrophy To Be Published
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8S5F
| Crystal structure of the HExxH domain of ChlBHExxH a novel alpha-ketoglutarate dependent oxygenase | 分子名称: | ChlH from Chlorogloeopsis sp., PHOSPHATE ION | 著者 | de la Mora, E, Amara, P, Usclat, A, Morishita, Y, Morinaka, B, Nicolet, Y. | 登録日 | 2024-02-23 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | Fused radical SAM and alpha KG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and beta-hydroxylation. Nat.Chem., 2024
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8U9L
| Crystal Structure of RelA-cRel chimera complex with DNA | 分子名称: | DNA (5'-D(P*GP*AP*AP*TP*CP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*TP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*GP*AP*TP*TP*C)-3'), Transcription factor p65,Proto-oncogene c-Rel chimera | 著者 | Chang, A, Wu, Y, Li, S.X, Smale, S, Chen, L. | 登録日 | 2023-09-19 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (3.091 Å) | 主引用文献 | Crystal Structure of RelA-cRel chimera complex with DNA To Be Published
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8UDS
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8V4T
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8V9N
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8VIU
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8VPV
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8VWX
| Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to Maltose-Binding Protein | 分子名称: | Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera | 著者 | Baird, J, Holliday, M. | 登録日 | 2024-02-02 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published
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8VWZ
| Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746 | 分子名称: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | 著者 | Baird, J, Holliday, M. | 登録日 | 2024-02-02 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published
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8VXM
| Human Bcl-2/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746 | 分子名称: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide | 著者 | Baird, J, Holliday, M. | 登録日 | 2024-02-05 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published
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8VXN
| Human Bcl-2/Bcl-xL Chimera Fused to Maltose-Binding Protein | 分子名称: | Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera | 著者 | Baird, J, Holliday, M. | 登録日 | 2024-02-05 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published
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8VZA
| Crystal Structure of 2-Hydroxacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, L-Lactyl-CoA, and ADP | 分子名称: | 2-Hydroxyacyl-CoA lyase/Synthase, 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ACETYL GROUP, ... | 著者 | Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A. | 登録日 | 2024-02-11 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Commun Chem, 7, 2024
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8VZB
| Crystal Structure of 2-Hydroxacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, D-Lactyl-CoA, and ADP | 分子名称: | 1,2-ETHANEDIOL, 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ACETIC ACID, ... | 著者 | Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A. | 登録日 | 2024-02-11 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Commun Chem, 7, 2024
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8VZC
| Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthse ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, Formyl-CoA, and ADP | 分子名称: | 1,2-ETHANEDIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(hydroxymethyl)-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A. | 登録日 | 2024-02-11 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Commun Chem, 7, 2024
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8VZD
| Crystal Structure of 2-Hydroxyacyl-CoA lyase/synthase TbHACS from Thermoflexaceae bacterium in the Complex with THDP, Formyl-CoA and ADP | 分子名称: | 1,2-ETHANEDIOL, 2-Hydroxyacyl-CoA Lyase/Synthase TbHACS, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Kim, Y, Maltseva, M, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A. | 登録日 | 2024-02-11 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Commun Chem, 7, 2024
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8VZE
| Crystal Structure of 2-Hydroxyacyl-CoA lyase/synthase TbHACS from Thermoflexaceae bacterium in the Complex with THDP, 2-Hydroxyisobutyryl-CoA and ADP | 分子名称: | 1,2-ETHANEDIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(hydroxymethyl)-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Kim, Y, Maltseva, M, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A. | 登録日 | 2024-02-11 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family. Commun Chem, 7, 2024
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